Influence of Apical Periodontitis on Stress Oxidative Parameters in Diabetic Rats

Prieto, Annelise Katrine Carrara; Gomes‐Filho, João Eduardo; Azuma, Mariane Maffei; Sivieri-Araújo, Gustavo; Narciso, Luı́s; Souza, Jucilene Conceição de; Ciarlini, Paulo César; Cintra, Luciano Tavares Ângelo

doi:10.1016/j.joen.2017.05.014

Cited by 27 publications

(28 citation statements)

References 32 publications

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“…Consequently, lesions in the periapical area were larger in diabetic rats compared to those in the control group. 26 Subsequently, other animal studies 6,[27][28][29][30][31] comparing the severity of inflammation and periapical bone loss between patients with diabetes and normoglycemic controls were conducted and are in agreement with the findings obtained by Kohsaka et al 26 In addition, one of these studies showed that diabetes may enhance the production of IL-17 in the AP site of rats, 31 confirming that diabetes may influence the inflammatory process in periapical tissues of rats with endodontic infection.…”

Section: Continuationsupporting

confidence: 77%

“…There are multiple studies identifying AP as a factor that can potentiate the symptoms caused by inflammatory diseases such as diabetes. 6,[17][18][19] However, there is limited evidence in the literature showing AP as the primary cause of systemic disorders. Studies in humans and animals have been conducted in order to determine systemic molecular changes in the body of individuals with no systemic disorders, but with AP.…”

Section: Methodsmentioning

confidence: 99%

“…4,5 These studies have emphasized the role of AP in systemic alterations in addition to the obvious local inflammation. 6,7 Consequently, studies have been performed to answer the following question: Does endodontic infection alter systemic health status?…”

Section: Introductionmentioning

confidence: 99%

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Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

et al. 2018

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Endodontic medicine, which addresses the bidirectional relationship between endodontic infections and systemic diseases, has gained prominence in the field of endodontics. There is much evidence showing that while systemic disease may influence the pathogenesis of endodontic infection, endodontic infection can also cause systemic alterations. These alterations include more severe bone resorption and inflammation in the periapical area as well as enhanced systemic disease symptoms. Similarly, many reports have described the impact of systemic diseases on the tissue responses to dental materials. Conversely, the local use of dental materials may show systemic effects in the form of altered production of biomarkers. Thus, studies to better understand the mechanisms related to those connections are extremely important. In this context, the objective of this review was to analyze and discuss the current literature regarding the connections among these three factors-systemic diseases, endodontic infection, and endodontic dental materials-and determine how these connections may interfere in the systemic health status and the endodontic treatment outcomes, which are represented by periapical wound healing.

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Section: Continuationsupporting

confidence: 77%

Section: Methodsmentioning

confidence: 99%

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Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

et al. 2018

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“…In another animal study (Prieto et al . ), it was found that, apical periodontitis did not alter the oxidative stress parameters in blood. Another study demonstrated that increased root canal endotoxin levels were associated with increased oxidative stress, severity of depression, and a lowered quality of life (Gomes et al .…”

Section: Discussionmentioning

confidence: 86%

“…In a pioneer study, conducted by Inchingolo et al (2014), it was reported that patients with chronic apical periodontitis exhibited significantly higher blood levels of oxidative stress than control patients and they suggested that subjects affected by chronic apical periodontitis are exposed to a condition of oxidative stress, which can be dangerous to general health. In another animal study (Prieto et al 2017), it was found that, apical periodontitis did not alter the oxidative stress parameters in blood. Another study demonstrated that increased root canal endotoxin levels were associated with increased oxidative stress, severity of depression, and a lowered quality of life .…”

Section: Discussionmentioning

confidence: 89%

Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Aksoy¹,

Savtekin

Şehirli

et al. 2019

Int Endodontic J

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Aim To investigate the possible therapeutic effects of alpha‐lipoic acid (ALA) in a model of chronic apical periodontitis in rats by analysing biochemical, histopathological and micro‐CT parameters. Methodology The study was approved by the Animal Ethics Committee of the Near East University. Thirty‐two Wistar rats were divided into four groups of eight rats each: Control Group; ALA Group; AP Group; AP + ALA Group. In the AP and AP + ALA groups, the pulp chambers of the mandibular first molars were surgically exposed and were left open to the oral environment for 4‐weeks to allow the establishment of periapical lesions. The rats in the Control and AP groups were treated intraperitoneally with saline solution (with a daily dose of 100 mg kg−1, for 28 days after periapical lesion induction). The rats in the ALA and AP + ALA groups were treated intraperitoneally with ALA (with a daily dose of 100 mg kg−1, for 28 days after periapical lesion induction). After decapitation, the trunk blood was collected for the assessment of biochemical parameters. The mandibles were surgically removed and dissected for histopathologic analysis and further scanned with micro‐CT. Groups of data were compared with a two‐way analysis of variance (two‐way anova) followed by Sidak's multiple comparison tests. Values of P < 0.05 were regarded as significant. Results TNF‐α, IL‐1β, MMP‐1, MMP‐2 levels were significantly lower in AP + ALA group compared with AP group (P < 0.05). There was a significant difference between the AP and AP + ALA groups according to assessment of the inflammatory scores (P < 0.05). The periapical inflammatory infiltrates were significantly more severe (P < 0.05) in the AP group. The AP + ALA group exhibited lower values both in terms of surface area and volume of resorption cavities than the AP group and this difference was significant (P < 0.05). Conclusion alpha‐lipoic acid treatment provided therapeutic effects on the inhibition of periapical bone loss.

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Experimental apical periodontitis alters salivary biochemical composition and induces local redox state disturbances in the salivary glands of male rats

Vazão,

Claudino,

Pimpinato

et al. 2024

Clin Oral Invest

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Influence of Apical Periodontitis on Stress Oxidative Parameters in Diabetic Rats

Abstract: Our findings indicate that diabetes may change the antioxidant status, increase the concentration of MDA and uric acid, and decrease albumin levels in the serum. In addition, AP can potentiate the effects of diabetes by reducing the levels of albumin and increasing the levels of uric acid.

Cited by 27 publications

References 32 publications

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Experimental apical periodontitis alters salivary biochemical composition and induces local redox state disturbances in the salivary glands of male rats

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