Influence of antipsychotic medication on pain perception in schizophrenia

Jochum, Thomas; Letzsch, A.; Greiner, W.; Wagner, Gerd; Sauer, Heinrich; Bär, Karl‐Jürgen

doi:10.1016/j.psychres.2005.09.004

Cited by 71 publications

(53 citation statements)

References 25 publications

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“…Some researches have been argued that antipsychotics have analgesic features and the differences in pain process in some schizophrenic patients may be related to this (32)(33)(34)(35). In our study, 33.3% of patients who had headache reported that their severity and duration of pain decreased after using the antipsychotic medication can be explained with the analgesic effect of the antipsychotics.…”

Section: Discussionsupporting

confidence: 46%

The evaluation of headache in patients with schizophrenia: a case-control study

Güveli¹,

Bahçeci²,

Kırbaş³

et al. 2014

Dusunen Adam

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Objective: The aim of this study is to explore the frequency and the types of headache in patients with schizophrenia and to compare it with the healthy control group.Method: A hundred and one patients and eighty nine healthy subjects were included in this case-control study. Socio-demographic data form, structured clinical interview for DSM disorders type 1 (SCID-1), Scale for the Assessment of the Negative Symptoms (SANS) and of the Positive Symptoms (SAPS) were applied. The subjects with headache were consulted to the neurology clinic.Results: The prevalence of headache in the patient group was 38.6% whereas the prevalence of headache in the control group was 37.1%. Tension type headache (TTH) was the most prominent type in both group (31.7% of patients, 18.0% of controls) and the presence of TTH in patients with schizophrenia was found statistically significant. Migraine type headache was detected in 2.0% of patients and 11.2% of controls. The ratio of headache was lesser in patients than in the controls.Conclusion: Schizophrenic patients have headache as much as the healthy subjects but they complain less about their headache than the controls do. Further studies with larger samples in patients with schizophrenia would present the importance of the issue and improve the quality of life in patients with schizophrenia contributing the analgesia.Key words: Headache, migraine, pain, psychiatric disorders, schizophrenia ÖZET Şizofrenli hastalarda baş ağrısının değerlendirilmesi: Vaka-kontrol çalışması Amaç: Bu çalışmada şizofrenli hastalarda sağlıklı kontrol grubu ile karşılaştırarak baş ağrısı sıklığı ve hangi tip baş ağrılarının olduğunun araştırılması amaçlandı.Yöntem: Çalışmaya 101 hasta ve 89 sağlıklı kontrol grubu alındı. Hastalara araştırmacılar tarafından hazırlanan, hastanın sosyo-demografik özelliklerinin, hastalığı ile ilgili bilgilerin ve baş ağrısı ile ilgili soruların yer aldığı sosyodemografik veri formu, DSM-IV eksen 1 tanı ölçütlerine göre hazırlanmış yapılandırılmış bir klinik görüşme formu olan SCID-1 ve Pozitif ve Negatif Belirtileri Değerlendirme Ölçeği uygulandı. Şu anda ya da geçmişte baş ağrısı olduğunu ifade eden hastalar baş ağrısının değerlendirilmesi amacıyla nöroloji polikliniğine yönlendirildi.Bulgular: Şizofrenli hasta grubunun %38.6'sı baş ağrısı tanımlarken, kontrol grubunda bu oran %37.1 olarak bulundu. Her iki grupta da en fazla gerilim tipi baş ağrısı (GTBA) görülmesine rağmen (hasta grubu=%31.7, kontrol grubu=%18) şizofreni grubunda GTBA kontrol grubundan anlamlı olarak daha fazla bulundu. Migren tipi baş ağrısı ise kontrol grubunun %11.2'sinde görülürken, hasta grubunun %2'sinde görülmekteydi. Şizofrenili hasta grubu kontrol grubuna göre baş ağrısı yakınmasını daha az dile getirmekteydi.Sonuç: Bu çalışmada şizofrenili hastaların normal popülasyon kadar baş ağrısına maruz kaldığı, baş ağrısı yakınmasını normal topluma göre daha az dile getirdikleri sonucu elde edilmiştir. Bu konuda yapılacak geniş örneklemli çalışmalar ve oluşturulacak tedavi protokolleri şizofrenili hastalar...

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Section: Discussionsupporting

confidence: 46%

The evaluation of headache in patients with schizophrenia: a case-control study

Güveli¹,

Bahçeci²,

Kırbaş³

et al. 2014

Dusunen Adam

View full text Add to dashboard Cite

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“…Several studies have addressed this possibility. When pain in schizophrenia was assessed by an experimental paradigm, antipsychotic medication appeared not to infl uence pain (Jochum et al 2006 ). A systematic review confi rmed that hypoalgesia as measured by experimental pain studies in schizophrenia is independent of antipsychotic medication (Potvin and Marchand 2008 ).…”

Section: Medicationmentioning

confidence: 99%

“…Indeed, cognitive performance depends on brain structures which are also part of the pain systems (e.g., ACC, PFC, hippocampus, and amygdala). When pain was tested with experimental thermal manipulation, the difference in pain perception between the persons with schizophrenia and those without was attributed to an impaired information processing (Jochum et al 2006 ). Cognitive inhibition, as regulated by PFC, is an important factor for inhibition of pain in healthy subjects (Oosterman et al 2010 ).…”

Section: Cognitionmentioning

confidence: 99%

Clinical Pain in Schizophrenia: A Forgotten Area

Engels¹,

Scherder²

2015

Pain, Emotion and Cognition

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Results from several studies suggest that pain experience is diminished in people with schizophrenia. A reduced sensitivity for pain would have implications for treating people for painful conditions in clinical practice. In this chapter, a short overview of pain in schizophrenia is provided along with discussion of some theoretical suggestions concerning the neuropathology of schizophrenia in pain-processing areas. Additionally, we mention possible confounders for pain research in persons with schizophrenia.

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“…Clinical investigations suggested that schizophrenic patients may have less sensitivity to different pain modalities (Kudoh et al 2000;Dworkin 1994;Bickerstaff et al 1988;Blumensohn et al 2002;Fishbain 1982;Singh et al 2006;Jochum et al 2006). An increased threshold of Cfibre functioning (Kudoh et al 2000) and a dysregulation of NMDA receptor transmission (Olney and Farber 1995) were proposed to account for this phenomenon.…”

Section: Introductionmentioning

confidence: 99%