Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia

Becker, Axel; Grecksch, Gisela; Zernig, Gerald; Ladstaetter, Elisabeth; Hiemke, Christoph; Schmitt, Ulrich

doi:10.1007/s00213-008-1336-z

Cited by 19 publications

(13 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite a recent meta‐analysis suggesting the insensitivity to pain in schizophrenia to be independent from medication (Potvin and Marchand, ), some earlier animal and human studies showed significant pain‐modifying effects for some antipsychotic agents (Fishbain et al., ; Becker et al., ). In order to rule out any confounding effects of medication in our study population, we only included unmedicated patients, thereby achieving the only small‐ to medium‐sized study population of 36 participants.…”

Section: Discussionmentioning

confidence: 99%

Increased cold and heat pain thresholds influence the thermal grill illusion in schizophrenia

Boettger

Großmann

Bär

2012

European Journal of Pain

View full text Add to dashboard Cite

CPT and HPT, as well as temperature differentials for the perception of the TGI were increased in patients with schizophrenia as compared to controls. Similar to visual illusions, in which reduced contrast sensitivity has been shown to alter the perception of illusions, the discriminatory somatosensory deficit, which is reflected in higher CPT and HPT as well as the previously reported increased warmth perception thresholds, might account for the attenuation of TGI in patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased cold and heat pain thresholds influence the thermal grill illusion in schizophrenia

Boettger

Großmann

Bär

2012

European Journal of Pain

View full text Add to dashboard Cite

show abstract

“…A supraspinal site, particularly the rostroventral medulla, was indicated as the site of action for potentiation of morphine analgesia by haloperidol [43]. The diminished analgesic response of morphine following ketamine pretreatment was also normalized by oral treatment with haloperidol [44]. Additionally, pretreatment with systemic haloperidol prevented the development of morphine tolerance and dependence and short-term treatment reversed the established morphine-antinociceptive tolerance and physical dependence in mice.…”

Section: Haloperidolmentioning

confidence: 97%

Investigational sigma-1 receptor antagonists for the treatment of pain

Vela

Almansa

2015

Expert Opinion on Investigational Drugs

View full text Add to dashboard Cite

There is a critical need for new analgesics based on new mechanisms of action. Target identification requires convincing evidence relating targets to function. In turn, target validation requires confirmation of therapeutic benefits, ideally in humans. Current preclinical evidence provides strong rationale for σ1R antagonists in pain. The outcome of clinical studies with the most advanced investigational σ1R antagonist, S1RA (E-52862), will be of great interest to ascertain the potential of this new therapeutic approach to pain management.

show abstract

“…As the subchronic NMDA-receptor antagonist model and the postweaning social isolation model of schizophrenic symptoms produce somewhat complementary, but not always robust behavioral alterations, some authors applied a combined "double hit" model to investigate the hypothesis that these manipulations can enhance the reliability of the schizophrenia model [35,36]. This paradigm applied in adult or juvenile rats induced several behavioral abnormalities, such as hyperresponsiveness to different stress situations, drugs and altered pain sensitivity [6,15,32,37,38]. Importantly, combining the two manipulations did not produce detectable additive or synergistic effects on behavior or hippocampal plasticity, however, these animals showed more schizophrenia-like signs.…”

Section: Introductionmentioning

confidence: 99%

Characterization of gene–environment interactions by behavioral profiling of selectively bred rats: The effect of NMDA receptor inhibition and social isolation

Petrovszki

Adam

Tuboly

et al. 2013

Behavioural Brain Research

View full text Add to dashboard Cite

Gene-environment interactions have an important role in the development of psychiatric disorders. To generate and validate a new substrain of rats with signs related to schizophrenia, we used selective breeding after postweaning social isolation and chronic ketamine treatment through several generations of animals and compared the subsequent strain to naive rats that were not genetically manipulated. We further investigated whether social isolation and ketamine treatment augmented the appearance of schizophrenic-like signs in these rats. Four experimental groups were studied (n=6-15 rats/group): naive rats without any treatment (NaNo); naive rats with postweaning social isolation and ketamine treatment (NaTr); 15th generation of selectively bred animals without any treatment (SelNo) or selectively bred rats with both isolation and ketamine treatment (SelTr). The startle reaction, tail-flick and novel object recognition tests were used to classify the animals into low- or high-risk for schizophrenia. Reduced pain sensitivity, higher degree of the startle reaction, disturbed prepulse inhibition, altered motor activity and decreased differentiation index in the memory test were observed in the 15th generation of the substrain, along with enhanced grooming behavior. Five functional indices (TF latency, startle reaction, prepulse inhibition, differentiation index, and grooming activity) were rated from 0 to 2, and the analysis of the summarized score revealed that the NaNo group had the lowest overall indication of schizophrenic-like signs, while the SelTr animals scored the highest, suggesting that both heritable and environmental factors were important in the generation of the behavioral alterations. We assume that further breeding after this complex treatment may lead to a valid and reliable animal model of schizophrenia.

show abstract

Haloperidol and risperidone have specific effects on altered pain sensitivity in the ketamine model of schizophrenia

Abstract: Hal and ris had different effects on altered pain sensitivity. It was hypothesised that these results are connected with alterations in dopamine D2 and mu opioid receptor binding.

Cited by 19 publications

References 54 publications

Increased cold and heat pain thresholds influence the thermal grill illusion in schizophrenia

Increased cold and heat pain thresholds influence the thermal grill illusion in schizophrenia

Investigational sigma-1 receptor antagonists for the treatment of pain

Characterization of gene–environment interactions by behavioral profiling of selectively bred rats: The effect of NMDA receptor inhibition and social isolation

Contact Info

Product

Resources

About