Influence of ankle-brachial blood pressure index(ABI) on mortality and cause of death

真理, 高野; 茂, 大坪; 直樹, 木全; 祐美, 小田; 貴之, 安部; 友樹, 岡島; 奈穂子, 三和; 隆, 秋葉; 孝作, 新田

doi:10.4009/jsdt.45.157

Cited by 5 publications

(7 citation statements)

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“…Among the six PAD patients whose cause of death was infection, the foci of infection included lower extremity gangrene in only two patients (13). The serum albumin and creatinine levels were lower, the serum C-reactive protein levels were higher and the hemoglobin levels were lower in the PAD group than in the non-PAD group (13). Many patients with malnutrition inflammation atherosclerosis (MIA) syndrome may have also been included in the PAD group.…”

Section: Discussionmentioning

confidence: 99%

“…An important issue in the management of patients with PAD is the elevated risk of cardiovascular disease, stroke and premature death (12). Moreover, we recently showed, in a series of 117 hemodialysis patients, that infection was significantly more prevalent in the PAD group than in the non-PAD group (13). Among the six PAD patients whose cause of death was infection, the foci of infection included lower extremity gangrene in only two patients (13).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, we recently showed, in a series of 117 hemodialysis patients, that infection was significantly more prevalent in the PAD group than in the non-PAD group (13). Among the six PAD patients whose cause of death was infection, the foci of infection included lower extremity gangrene in only two patients (13). The serum albumin and creatinine levels were lower, the serum C-reactive protein levels were higher and the hemoglobin levels were lower in the PAD group than in the non-PAD group (13).…”

Section: Discussionmentioning

confidence: 99%

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Effects of the Ankle-brachial Blood Pressure Index and Skin Perfusion Pressure on Mortality in Hemodialysis Patients

et al. 2013

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Objective Clinically, the ankle-brachial blood pressure index (ABI) and skin perfusion pressure (SPP) are used to screen for subclinical peripheral artery disease. However, the association between the SPP and mortality in hemodialysis patients has not been previously reported. We investigated these factors and compared the ABI and SPP in patients receiving hemodialysis. Methods A total of 102 patients receiving maintenance hemodialysis were enrolled in this study. The ABI was determined using an ABI-form (Colin, Japan). The SPP was measured using a SensiLase TM PAD3000 (Kaneka, Osaka, Japan). Results The mean follow-up period was 3.2±1.4 years. A multivariate Cox analysis identified a low ABI (p=0.019) and a low SPP (p=0.047) as being independent predictors of mortality. A receiver operating characteristic (ROC) analysis of the ABI revealed a cutoff point of 1.1 and an area under the curve (AUC) of 0.79, with a sensitivity of 90% and a specificity of 62%. A ROC analysis of the SPP revealed a cutoff point of 54.0 mmHg and an AUC of 0.71, with a sensitivity of 55% and a specificity of 84%. Conclusion Both low ABI and SPP values were found to be independent risk factors for mortality among hemodialysis patients. The cutoff point for ABI as a predictor of mortality was 1.1, while that for SPP was 54.0 mmHg.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of the Ankle-brachial Blood Pressure Index and Skin Perfusion Pressure on Mortality in Hemodialysis Patients

et al. 2013

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“…PAD is recognized as a polyvascular disease because of the frequent coexistence of coronary artery and [13]. Moreover, we recently showed that, in a study examining 117 hemodialysis patients, infection was significantly more prevalent in the PAD group than in the non-PAD group [8]. Both the short-term and long-term outcomes of hemodialysis patients with PAD have been reported to be poor [6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…PAD is a regular complication of hemodialysis patients [3,4] and is associated with poor outcomes [4][5][6][7][8][9]. Clinically, the anklebrachial blood pressure index (ABI) is highly correlated with PAD of the lower extremities [10], and ABI is an independent predictor of all-cause mortality in hemodialysis patients [6][7][8][9]. A recent study also revealed that not only the value of the ABI itself but also the rate of the reduction in the ABI was a risk factor for cardiovascular mortality [11].…”

Section: Introductionmentioning

confidence: 99%

Changes in the ankle-brachial blood pressure index among hemodialysis patients

Abe

Otsubo²,

Naoki

et al. 2016

Ren Replace Ther

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Background: The ankle-brachial blood pressure index (ABI) is an independent predictor of mortality in hemodialysis patients. In the present study, we investigated the factors that predict changes in the ABI in hemodialysis patients. Conclusions:We confirmed that not only the value of the ABI itself but also the change in the ABI was a risk factor for mortality among hemodialysis patients. The change in the ABI was negatively correlated with age and was positively correlated with the serum creatinine level. Careful observation of the ABI is needed for old patients and patients with a low serum creatinine level.

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Associations between brachial-ankle pulse wave velocity (baPWV) and clinical parameters in hemodialysis patients

輝美¹,

由美子²,

直³

et al. 2013

Nihon Toseki Igakkai Zasshi

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Objectives：Hemodialysis patients are at an increased risk of atherosclerotic complications. Brachial-ankle 樋口輝美博鳳会敬愛病院腎臓内科〒 173-0036 東京都板橋区向原 3-10-23 Terumi Higuchi Tel：03-3973-3811 Fax：03-3530-3030 E-mail：thiguchi@keiai-hospital.jp 〔受付日：2013 年 2 月 14 日，受理日：2013 年 4 月 1 日〕目的：透析患者は動脈硬化関連合併症の状態にさらされている．動脈硬化症の指標である brachial-ankle pulse wave velocity(baPWV)は簡易に測定することが可能な device であり，透析患者の baPWV を測定し，種々のパラメーターとの関連について検討した．対象・方法：安定した維持血液透析中の患者 138 名のうち，ABI が 0.9 以上 1.3 以下の正常患者 98 名．baPWV は form PWV／ABI(日本オムロンコーリン社)にて測定した．血液サンプルは週始めの透析前後に行い，DNA の酸化ストレスのマーカーの 8-OHdG，炎症性サイトカインの IL-6，動脈硬化関係の fetuin-A は ELISA にて測定した．栄養関連では GNRI を算出し，ESA の過去 1 か月の使用状況で ERI を検討した．結果：baPWV の性差，原疾患が糖尿病群と非糖尿病群との検討では，有意な差は認めなかった．年齢と有意な正の相関を認め，透析歴とも有意な正の相関を認めた．栄養関係の血清アルブミンとは有意な負の相関を認め， GNRI とも有意な負の相関を認めた．また体重とは有意な負の相関を認め，BMI とも有意な負の相関を認めた．炎症のマーカーである IL-6 とは有意な正の相関を認めたが，fetuin-A や 8-OHdG とは有意な相関は認めなかった．血清 Cr とは有意な負の相関を認め，補正カルシウムとは有意な正の相関を認め， TIBC とも有意な負の相関を認め， b2-MG とは有意な正の相関関係を認め，ERI とも有意な正の相関を認めた．多変量解析では，血清 Cr と b2-MG と有意な相関を認めた．結論：baPWV は動脈硬化症に関連する炎症，栄養状態および年齢，透析歴，中分子量物質， TIBC，補正カルシウム，ERI などにも関与し，特に血清 Cr と b2-MG がその規定因子になることが示唆された．〈要旨〉キーワード：樋口輝美 1 石川由美子 2 堀田直 3 水野真理 1 大川恵里奈 1 安藤英之 4 博鳳会敬愛病院腎臓内科 1 博鳳会敬愛病院透析センター 2 博鳳会敬愛病院臨床検査科 3 博鳳会敬愛病院循環器内科 4 血液透析患者の brachial-ankle pulse wave velocity (baPWV) と各種パラメーターとの関連についての検討原著血液透析，baPWV，栄養，炎症，ESA，ERI

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Influence of ankle-brachial blood pressure index(ABI) on mortality and cause of death

Cited by 5 publications

References 20 publications

Effects of the Ankle-brachial Blood Pressure Index and Skin Perfusion Pressure on Mortality in Hemodialysis Patients

Effects of the Ankle-brachial Blood Pressure Index and Skin Perfusion Pressure on Mortality in Hemodialysis Patients

Changes in the ankle-brachial blood pressure index among hemodialysis patients

Associations between brachial-ankle pulse wave velocity (baPWV) and clinical parameters in hemodialysis patients

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