Influence of anionic monomer content on the biodegradation and toxicity of polyvinyl-urethane carbonate-ceramic interpenetrating phase composites

Synthesis and Characterization of Degradable Polar Hydrophobic Ionic Polyurethane Scaffolds for Vascular Tissue Engineering Applications

“…In this study, a PCN soft segment was chosen, which has been shown to improve the tensile strength of PUs when compared to conventional polyether-urethanes (PEUs) . Furthermore, studies by Tang et al − and Yang et al have demonstrated polycarbonate-urethanes’ (PCNUs) susceptibility to hydrolytic degradation in vitro, making them excellent candidates for degradable tissue engineering scaffolds. The products of PCN hydrolysis are carbon dioxide and hexane diol, which should not illicit a host immune response .…”

A study of vascular smooth muscle cell function under cyclic mechanical loading in a polyurethane scaffold with optimized porosity

“…Also, the latter scaffolds' identical polymer chemistry and composition ensured an equal number of hydrophilic H-bond-forming groups (NAH and C@O), a constant degree of H-bonding with the surrounding water molecules and, in turn, a lack of change in polymer swelling [45,46]. Finally, due to the similar number of ionic groups (COOH in the MAA), D-PHI-0P to D-PHI-20P scaffolds were suspected to have a similar propensity to uptake water [30,47]. The electrostatic repulsion present between these ionic groups (COO À ) should also remain relatively constant, explaining the statistically similar degree of swelling [48,49].…”

“…Gravimetric analysis was used to measure scaffold swelling in aqueous environments based on a previously described protocol reported by Yang et al [30]. Briefly, porous disc-shaped D-PHI scaffolds (4 mm diameter, 3 mm thickness) were incubated in Dulbecco's modified Eagle's medium (DMEM) for 5 days at 37°C.…”

Fabrication of a biodegradable calcium polyphosphate/polyvinyl‐urethane carbonate composite for high load bearing osteosynthesis applications

“…Attempts to form PFCs with higher vol % CPP proved difficult due to particle clustering and problems in achieving good particle distribution. 27 Although the FRC structures provided higher stiffness in one direction (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) GPa bending elastic constant for 50 vol % samples; higher volume fractions were difficult to produce while maintaining an even fiber distribution), the composite was highly anisotropic and displayed poor machining characteristics. 27 Although complex lamellar designs and fabrication processes could be potentially used to overcome this limitation, this was not pursued in view of the relatively straightforward procedures developed for forming IPC structures with E Bending $ 20-40 GPa.…”

“…The current study focused on the design, formation, and characterization of IPC samples made from CPP (a biodegradable ceramic) and a biodegradable polymeric phase (polyvinyl-urethane carbonate copolymer-PVUC). These constituent materials and their degradation products have been shown to be biocompatible 30,31 and biodegradable. 32 Further, when a specific blend of the PVUC, termed ''PRMAA20,'' which contained methacrylic acid, and described below, was combined with the CPP to form a composite, strong ionic interfacial bonding occurred between the phases.…”