Influence of anesthetics on the attenuation of baroreflex following transient global cerebral ischemia: comparison between barbiturates and halothane

Kurihara, Junichi; Sahara, Tatsuhiro; Tomita, Hirofumi; Katô, Hiroaki

doi:10.1016/0014-2999(90)92688-f

Cited by 3 publications

(2 citation statements)

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“…The neuroprotective effect of ifenprodil was also demonstrated following asphyxial cardiac arrest in rats [44]. Interestingly, ifenprodil treatment also protected the vagal component of baroreflex during cerebral ischemia [45,46]. However, using the global ischemic brain injury model in gerbils, Araki et al [47] could not find that ifenprodil was neuroprotective.…”

Section: Global Ischemic Brain Injurymentioning

confidence: 92%

NMDA/NR2B Selective Antagonists in the Treatment of Ischemic Brain Injury

Wang

Shuaib

2005

CDTCNSND

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Glutamate is the main excitatory neurotransmitter in the central nervous system and it plays a significant role not only in synaptic transmission but also in acute and chronic neuropathologies including stroke. Presently, four receptors for glutamate have been identified and the NMDA receptor family is the most intensively studied. A number of NMDA receptor antagonists have been developed and used for treatment of neurological diseases in patients. However, all of these drugs have been failed in clinical trials either because of intolerable side effects or lack of medical efficacy. Recently, the understanding of molecular structure of NMDA receptors has been advanced and this finding thus provides information for designing subtype-selective antagonists. Using NR2B subunit selective antagonists, ifenprodil and eliprodil, as basic structure models, second and third generation congeners have been developed. Several NR2B-selective compounds showed neuroprotective actions at doses that did not produce measurable side effects in preclinical studies. Some of NR2B subunit selective antagonists have also been tested for the treatment of ischemic brain injury. The present review describes the role of glutamate in ischemic brain injury with an emphasis on the NR2B containing NMDA receptors.

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Section: Global Ischemic Brain Injurymentioning

confidence: 92%

NMDA/NR2B Selective Antagonists in the Treatment of Ischemic Brain Injury

Wang

Shuaib

2005

CDTCNSND

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“…The results were compared with those from our previous experiments on animals under pentobarbital anesthesia; and unex pectedly, we found that the vagal baroreflex system may be more resistant to ischemia under halothane anesthesia in comparison with barbiturate anesthesia. Part of this study was presented at the XIth International Congress of Pharmacology (8).…”

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confidence: 99%

Difference between Halothane and Barbiturate Anesthesia in the Influence of Cerebral Ischemia on the Vagal Baroreflex in Dogs.

Kurihara

Kato

1992

Jpn.J.Pharmacol

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ABSTRACT-In halothane-anesthetized dogs, a decrease in baroreflex sensitivity (BRS) of approximately 20% was observed during the reperfusion period following 5 min global cerebral ischemia. When compared with our previous study on animals under pentobarbital anesthesia, the extent of the decrease in BRS was smaller and apparently more severe ischemia was necessary to damage the vagal component of the baroreflex. Substitution of halothane with pentobarbital during the reperfusion period failed to affect either BRS or the ratio of the vagal component. In another group, pre and post-ischemic measurements of BRS was performed under halothane anes thesia, but the ischemic insult was given under thiopental anesthesia. In these animals, the extent of decrease in BRS (about 50%) was greater than that in animals subjected to ischemia under halothane anesthesia. The present results suggest that the anesthe tics used during the ischemic insult may affect the extent of post-ischemic dysfunction of the baroreflex. The vagal component of the baroreflex may be more resistant to ischemia under halothane anesthesia than under barbiturate anesthesia.

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