Influence of an anionic hydrotrope on thermophysical properties of an anionic surfactant sodium dodecyl sulfate

Rajendran, Sumitha Kanniappan; Mondal, Julfikar Hassan; Alam, Md. Sayem

doi:10.1016/j.cplett.2021.139239

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Akin to surfactants that aggregate into micelles above the critical micellar concentration (CMC), hydrotropes self-associate above their minimum hydrotrope concentration (HMC) , and can reduce the surface tension of water . The hydrophobic portion of hydrotropes is either short alkyl groups or aromatic rings as opposed to long hydrocarbon chains in surfactants (C 16 –C 18 ), resulting in higher hydrophilic/lipophilic balance (HLB)a factor that accounts for the higher concentration of hydrotrope (μmolL –1 to mmolL –1 ) required for solubilization. ,,, Hydrotropes have been utilized, since their inception, to improve the water solubility of a wide range of organic compounds, namely, drugs and biochemicals. − They often improve the micellization property of surfactants through synergistic noncovalent interactions. − The differential solvent affinity of the constituent ions has been exploited for various extraction-related applications. − The dissolved solute can be precipitated and recovered effortlessly by diluting the hydrotropic solution. , …”

Section: Introductionmentioning

confidence: 99%

Elucidating the Hydrotropic Mechanism of the Antagonistic Salt PPh₄Cl

2023

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PPh4Cl is an antagonistic salt that recently showed promise as a hydrotropic agent. Here, we give mechanistic insights into the PPh4Cl-assisted solubility of a dye molecule using molecular dynamics simulations. Our findings reveal that dye molecules aggregate into a cluster which leads to an accumulation of PPh4 + ions in its vicinity and subsequent exclusion of water molecules from the region. The structural organization is attributed to the preferential interaction of dye molecules and PPh4Cl. The origin of such preference arises from the difference in π–π and CH–π interaction among the pairs. The hydrodynamic radius of PPh4Cl indicates a low propensity for cluster formation, which enhances its hydrotropic behavior. The process of dye dissolution is thermodynamically favored and occurs through a cooperative mechanism. Our studies provide molecular insight into experimental observations crucial for the design of novel hydrotropes with enhanced solubilizing properties.

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