Hydrotropes: Solubilization of nonpolar compounds and modification of surfactant solutions

Zakharova, L. Ya.; Vasilieva, Elmira A.; Mirgorodskaya, A. B.; Захаров, С. В.; Pavlov, Rais; Kashapova, Nadezda E.; Gaynanova, Gulnara A.

doi:10.1016/j.molliq.2022.120923

Cited by 11 publications

(4 citation statements)

References 187 publications

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“…The most common ways to increase the solubility of drugs are the use of hydrotropes, surfactant-based nanocarriers, and changing environmental conditions, such as temperature, pH, etc. [ 81 ]. Micelles attract wide attention, providing multiple increases in solubility of different practically relevant substrates (drugs, food, chemical dyes, cosmetics, pesticides, etc.…”

Section: Resultsmentioning

confidence: 99%

“…In accordance with the literature, including our works, the solubilization activity of cationic surfactants depends on the nature of their head group and the type of drug. Moreover, in many cases, the solubilization capacity of cationic amphiphiles with a cyclic head group is higher compared to open head group analogs [ 81 , 82 ]. Therefore, the solubilization ability of mixed surfactant–PE systems toward poorly water-soluble drugs of various therapeutic effects (non-steroidal anti-inflammatory agent (NSAID)-meloxicam ( Figure 13 ), anticoagulant-warfarin ( Figure 14 ), and antifungal antibiotic-amphotericin B ( Figure 15 )) was investigated.…”

Section: Resultsmentioning

confidence: 99%

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Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers

et al. 2023

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Objectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to create functional nanosystems with controlled properties. Research hypothesis. Mixed PE–surfactant complexes based on oppositely charged species are characterized by multifactor behavior strongly affected by the nature of both components. It was expected that the transition from a single surfactant solution to an admixture with PE might provide synergetic effects on structural characteristics and functional activity. To test this assumption, the concentration thresholds of aggregation, dimensional and charge characteristics, and solubilization capacity of amphiphiles in the presence of PEs have been determined by tensiometry, fluorescence and UV-visible spectroscopy, and dynamic and electrophoretic light scattering. Results. The formation of mixed surfactant–PAA aggregates with a hydrodynamic diameter of 100–180 nm has been shown. Polyanion additives led to a decrease in the critical micelle concentration of surfactants by two orders of magnitude (from 1 mM to 0.01 mM). A gradual increase in the zeta potential of HAS–surfactant systems from negative to positive value indicates that the electrostatic mechanism contributes to the binding of components. Additionally, 3D and conventional fluorescence spectroscopy showed that imidazolium surfactant had little effect on HSA conformation, and component binding occurs due to hydrogen bonding and Van der Waals interactions through the tryptophan amino acid residue of the protein. Surfactant–polyanion nanostructures improve the solubility of lipophilic medicines such as Warfarin, Amphotericin B, and Meloxicam. Perspectives. Surfactant–PE composition demonstrated beneficial solubilization activity and can be recommended for the construction of nanocontainers for hydrophobic drugs, with their efficacy tuned by the variation in surfactant head group and the nature of polyanions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers

et al. 2023

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“…The sulfonic acid can be ionized or dissociated due to its electrical conductivity and dissolve biomass components in an aqueous solution. 64,66 Maleic acid is another acid hydrotrope for plant biomass fractionation. 49 It is a dicarboxylic acid with a polar group (hydrophilic) on one side and a non-polar CC bond on the opposite side.…”

Section: Characteristics Of Hydrotropesmentioning

confidence: 99%

Recent advances in hydrotropic solvent systems for lignocellulosic biomass utilization

Jeong,

Ryu,

Yang

et al. 2024

Green Chem.

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“…To overcome this issue, chemicals such as surfactants, hydrotropes, and kosmotropes can be added for increasing the solubility of hydrophobic substances in pharmaceutical science, − biomedicine, − catalytic, , cosmetic science, − and anticorrosion , applications. Whereas surfactants can lead to uncontrollable aggregation characteristics and may have strong detrimental interactions with cells membranes, hydrotropes and kosmotropes were used as environmentally responsible molecules for increasing the water solubility of payloads. − ,,,− ,− The agents are typically characterized by an amphiphilic molecular structure. However, they are distinguished from surfactants due to deficiency of the hydrophobic part to produce well-organized self-associated aggregates such as micelles .…”

Section: Introductionmentioning

confidence: 99%

Cascade Release of Payloads from Polymer Nanofibers with Conjugated Hydrotropes and Kosmotropes

Kongkatigumjorn,

Crespy

2024

Macromolecules

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Over 60% of hydrophobic substances currently exploited in the pharmaceutical industry encounter a reduction of therapeutic efficacy due to limited water solubility. Herein, we report a strategy for exhibiting a sustained and large amount of released payloads while allowing for their controlled release upon specific conditions. The strategy relies on the conjugation of solubilizers to polymers via responsive linkages, which are used as a matrix for the encapsulation of payloads. In the presence of mild acidic conditions, hydrotropes and kosmotropes are released from polymer nanofibers after cleavage of thioether ester linkages, subsequently inducing the release of drugs and dyes used as model payloads. This approach can be applied for preparing materials for an enhanced delivery of hydrophobic sensor molecules, drugs, phytosanitary treatments, or corrosion inhibitors.

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Hydrotropes: Solubilization of nonpolar compounds and modification of surfactant solutions

Cited by 11 publications

References 187 publications

Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers

Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers

Recent advances in hydrotropic solvent systems for lignocellulosic biomass utilization

Cascade Release of Payloads from Polymer Nanofibers with Conjugated Hydrotropes and Kosmotropes

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