Influence of aging on the quality of the skin of white women: the role of collagen

Baroni, Eloina do Rocio Valenga; Biondo-Simões, Maria de Lourdes Pessole; Auersvald, André; Auersvald, Luiz Augusto; Netto, Mário Rodrigues Montemór; Ortolan, Morgana Cláudia Aparecida Bergamo; Kohler, Juliana Nemetz

doi:10.1590/s0102-86502012001000012

Cited by 39 publications

(46 citation statements)

References 9 publications

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“…MMPs are degrading enzymes that act on extracellular matrix molecules by inducing the advent of fragmented collagen remainders in the tissue (Hern andez-P erez & Mahalingam, 2012). This is congruous with the thickness reduction in collagen bundles that we observed in papillary and reticular dermis according to age, and supports the observation of thinner and more fragmented collagen bundles in aged dermis reported by other studies (Varani et al 2001(Varani et al , 2006Baroni Edo et al 2012;El-Aal et al 2012).…”

Section: About Skin Ageingsupporting

confidence: 92%

Age‐related dermal collagen changes during development, maturation and ageing – a morphometric and comparative study

et al. 2014

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The tissue organisation of dermal collagen is gaining importance as a contributing factor both in development and ageing, as well as in skin maturation processes. In this work we aim to study different representative parameters of this structural organisation in 45 human skin samples of assorted ages, by means of image analysis. The variation of these parameters on the basis of age was assessed using several regression models (linear, quadratic and cubic). The area occupied by collagen was significantly reduced as a function of age in the papillary dermis (R 2 = 0.437, P < 0.0001), as well as the thickness of the collagen bundles (R 2 = 0.461, P < 0.0001), following statistical models of cubic and quadratic regression, respectively. The width of the papillary dermis increased in a significant manner over a linear regression model (R 2 = 0.26, P < 0.0001). In the reticular dermis, the cubic regression indicated a significant decline (R 2 = 0.392, P = 0.002) of the area filled with collagen according to the age. Both collagen thickness and bundle orientation parameters fit a quadratic regression over the age in a significant way (R 2 = 0.433 and R 2 = 0.334, respectively, both P < 0.0001). The width of the reticular dermis followed also a significant quadratic distribution according to age (R 2 = 0.193, P = 0.011). These parameters could partially explain the lifelong functional changes taking place in the skin and propose a baseline providing a useful entry point for future investigation.

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Section: About Skin Ageingsupporting

confidence: 92%

Age‐related dermal collagen changes during development, maturation and ageing – a morphometric and comparative study

et al. 2014

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“…The major structural component of fibrillin-rich microfibrils, fibrillin-1, was also analysed, since it is a sensitive indicator of intrinsic and extrinsic skin aging (Naylor et al, 2011;Watson et al, 1999;2008;2014), along with mature collagen type I and III, since their expression decreases progressively during skin aging (Attia-Vigneau et al, 2014;Baroni Edo et al, 2012;Berneburg, 2008;Gilchrest, 2013;Langton et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis

Vidali

Chéret

Giesen

et al. 2016

Journal of Investigative Dermatology

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Since it is unknown whether thyroid hormones (THs) regulate mitochondrial function in human epidermis, we treated organ-cultured human skin, or isolated cultured human epidermal keratinocytes, with triiodothyronine (100 pmol/L) or thyroxine (100 nmol/L). Both THs significantly increased protein expression of the mitochondrially encoded cytochrome C oxidase I (MTCO1), complex I activity, and the number of perinuclear mitochondria. Triiodothyronine also increased mitochondrial transcription factor A (TFAM) protein expression, and thyroxine stimulated complex II/IV activity. Increased mitochondrial function can correlate with increased reactive oxygen species production, DNA damage, and accelerated tissue aging. However, THs neither raised reactive oxygen species production or matrix metalloproteinase-1, -2 and -9 activity nor decreased sirtuin1 (Sirt1) immunoreactivity. Instead, triiodothyronine increased sirtuin-1, fibrillin-1, proliferator-activated receptor-gamma 1-alpha (PGC1α), collagen I and III transcription, and thyroxine decreased cyclin-dependent kinase inhibitor 2A (p16(ink4)) expression in organ-cultured human skin. Moreover, TH treatment increased intracutaneous fibrillin-rich microfibril and collagen III deposition and decreased mammalian target of rapamycin (mTORC1/2) expression ex vivo. This identifies THs as potent endocrine stimulators of mitochondrial function in human epidermis, which down-regulates rather than enhance the expression of skin aging-related biomarkers ex vivo. Therefore, topically applied THs deserve further exploration as candidate agents for treating skin conditions characterized by reduced mitochondrial function.

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“…Aging and extrinsic factors, such as ultraviolet light and ozone exposure, the effects of smoking, and environmental pollution, result in increased skin roughness, wrinkling, dryness, and discoloration . These changes in appearance are a result of structural changes in the skin that include disorganization and fragmentation of dermal elastic fibers, reduced barrier function, diminished collagen, and decreased skin thickness …”

Section: Introductionmentioning

confidence: 99%

Improvements in satisfaction with skin after treatment of facial fine lines with VYC‐12 injectable gel: Patient‐reported outcomes from a prospective study

Ogilvie¹,

Safa²,

Chantrey³

et al. 2019

J of Cosmetic Dermatology

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Background: VYC-12, a hyaluronic acid injectable gel, is designed to treat fine lines and provides improvements in other skin quality attributes. A prospective study demonstrated the safety and effectiveness of VYC-12 for the improvement of fine lines as measured by changes in skin texture. Aims:To evaluate patient-reported outcomes in subjects treated intradermally with VYC-12 in the cheeks, forehead, and neck (optional) in the prospective study.Methods: Subjects received an initial treatment of VYC-12 (N = 131), with a touch-up treatment, if deemed necessary, offered 30 days later, and optional repeat treatment 9 months after initial or touch-up treatment. Subjects completed the FACE-Q Satisfaction With Skin scale and assessed willingness to recommend treatment to a friend at baseline, months 1, 4, 6, and 9, and month 1 after repeat treatment. Subjects also evaluated their return to normal daily social activities.Results: Satisfaction with skin improved from baseline in 90.8% of subjects at month 1, 88.4% at month 4, 83.6% at month 6, 76.4% at month 9, and 91.9% at month 1 after repeat treatment (P < .001, all time points). At least 94% of subjects returned to normal daily social activities one day after treatment (initial, touch-up, or repeat).More than 80% of subjects said they would recommend treatment to a friend at all time points through month 9 (97% at month 1 after repeat treatment). Conclusion:Treatment with VYC-12 significantly improved satisfaction with skin in the majority of subjects, with most subjects returning to normal activities 1 day after treatment. K E Y W O R D Saesthetics, dermal fillers, hyaluronic acid, patient-reported outcome measures, skin aging

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Influence of aging on the quality of the skin of white women: the role of collagen

Abstract: There is reduction in collagen with increasing age, and an increase in its degradation, leading to fragmentation of the fibers.

Cited by 39 publications

References 9 publications

Age‐related dermal collagen changes during development, maturation and ageing – a morphometric and comparative study

Age‐related dermal collagen changes during development, maturation and ageing – a morphometric and comparative study

Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis

Improvements in satisfaction with skin after treatment of facial fine lines with VYC‐12 injectable gel: Patient‐reported outcomes from a prospective study

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