2012
DOI: 10.1590/s0102-86502012001000012 View full text |Buy / Rent full text
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Abstract: There is reduction in collagen with increasing age, and an increase in its degradation, leading to fragmentation of the fibers.

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“…MMPs are degrading enzymes that act on extracellular matrix molecules by inducing the advent of fragmented collagen remainders in the tissue (Hern andez-P erez & Mahalingam, 2012). This is congruous with the thickness reduction in collagen bundles that we observed in papillary and reticular dermis according to age, and supports the observation of thinner and more fragmented collagen bundles in aged dermis reported by other studies (Varani et al 2001(Varani et al , 2006Baroni Edo et al 2012;El-Aal et al 2012).…”
Section: About Skin Ageingsupporting
“…The major structural component of fibrillin-rich microfibrils, fibrillin-1, was also analysed, since it is a sensitive indicator of intrinsic and extrinsic skin aging (Naylor et al, 2011;Watson et al, 1999;2008;2014), along with mature collagen type I and III, since their expression decreases progressively during skin aging (Attia-Vigneau et al, 2014;Baroni Edo et al, 2012;Berneburg, 2008;Gilchrest, 2013;Langton et al, 2012).…”
Section: Introductionmentioning
“…Aging and extrinsic factors, such as ultraviolet light and ozone exposure, the effects of smoking, and environmental pollution, result in increased skin roughness, wrinkling, dryness, and discoloration . These changes in appearance are a result of structural changes in the skin that include disorganization and fragmentation of dermal elastic fibers, reduced barrier function, diminished collagen, and decreased skin thickness …”
Section: Introductionmentioning
“…Consequently, the use of sunscreen has become necessary. 1 The skin of adults goes through several profound transformations as the age of an individual advances. The following physiological alterations to the cutaneous tissue occur: greater cutaneous fragility; a weaker barrier against external factors; insufficient thermoregulation to deal with heat, caused by the decrease in the number of sweat glands; rough, dry skin, caused by the reduction in the number of sebaceous glands, which leads to low oil production; less sensitive stimulation; a decrease in elasticity; flabbiness; alterations to the immunological cellular response and a thinner dermis and epidermis.…”
Section: Introductionmentioning
“…Various pathologies including arthritis, osteoporosis, skin disorders, and some vascular disorders are thought to result from unregulated and excessive collagen degradation. For example, menopause-and aging related collagen loss does not only affect bones but also decreases the skin collagen content by 50–70% 13 . Besides the well-known collagenases of the matrix metalloprotease family, the papain-like cysteine protease, cathepsin K (CatK) has been recognized as a major collagenase in bone, cartilage, and in other organs as well 4 .…”
Section: Introductionmentioning