Influence of age-related learning and memory capacity of mice: different effects of a high and low caloric diet

Dong, Wen; Wang, Rong; Ma, Lina; Xu, Baolei; Zhang, Jingshuang; Zhao, Zhigang; Wang, Yulan; Zhang, Xu

doi:10.1007/s40520-015-0398-0

Cited by 49 publications

(41 citation statements)

References 44 publications

(49 reference statements)

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“…The authors also state that weight loss may decrease risk of developing dementia [42]. Corroborating this idea, another study demonstrated that long-term consumption of a high-calorie diet could inhibit autophagy function and facilitate neuronal loss in the hippocampus, which in turn aggravate age related cognition impairment [43]. In accordance, besides the improvement of cognitive function, the present study also found a significant reduction on body mass and BMI after grape juice consumption in all individuals.…”

Section: Discussionsupporting

confidence: 81%

Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women

Costa¹,

Dorneles²,

Silva³

et al. 2017

J Syst Integr Neurosci

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Objective: To verify the chronic consumption of grape juice effects on weight, body mass index (BMI), cognitive function and the peripheral levels of global histone H4 acetylation, BDNF and inflammatory markers in elderly women according to age. Methods: This is a quasi-experimental study. The blood samples were collected before and after 30 days of grape juice supplementation (400 ml/daily) in women aged > 70 and < 70 years old. Weight, BMI and cognitive function, were measured before and after supplementation. Results: Grape juice consumption promoted a reduction on weight and BMI. This consumption also contributed to improve a cognitive function. These effects were more pronounced in the >70 years group. A tendency towards increased BDNF levels was observed in the >70 years group after intervention. Inflammatory markers and global histone H4 levels did not change. Conclusion: The chronic grape juice consumption is an interesting choice to promote health benefits in elderly women, which seem to act in an age-dependent manner.

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Section: Discussionsupporting

confidence: 81%

Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women

Costa¹,

Dorneles²,

Silva³

et al. 2017

J Syst Integr Neurosci

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“…For example, Ma et al investigated 30% CR from 7–30 weeks of age in male B6 mice and noted significantly better performance in both learning and memory performance(Ma et al, 2014). In a study from the same group, Dong et al confirmed that 30% CR for 10 mo improved both learning and memory in the MWM compared to controls (Dong et al, 2016). …”

Section: Does Cr Attenuate Cognitive Decline?mentioning

confidence: 91%

Calorie restriction in rodents: Caveats to consider

Ingram

Cabo

2017

Ageing Research Reviews

105

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The calorie restriction paradigm has provided one of the most widely used and most useful tools for investigating mechanisms of aging and longevity. By far, rodent models have been employed most often in these endeavors. Over decades of investigation, claims have been made that the paradigm produces the most robust demonstration that aging is malleable. In the current review of the rodent literature, we present arguments that question the robustness of the paradigm to increase lifespan and healthspan. Specifically, there are several questions to consider as follows: (1) At what age does CR no longer produce benefits? (2) Does CR attenuate cognitive decline? (3) Are there negative effects of CR, including effects on bone health, wound healing, and response to infection? (4) How important is schedule of feeding? (5) How long does CR need to be imposed to be effective? (6) How do genotype and gender influence CR? (7) What role does dietary composition play? Consideration of these questions produce many caveats that should guide future investigations to move the field forward.

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“…It has been noted that mild changes in the external environment that affect circadian rhythm may alter cognition. Chronic sleep fragmentation has been shown to affect autophagy proteins in the hippocampus (123) that may affect memory and cognition (48, 56, 102, 124, 125). Autophagy in the hippocampus also is depressed during the absence of the PER1 circadian clock protein that may worsen the pathology of cerebral ischemia (126).…”

Section: Circadian Clock Genesmentioning

confidence: 99%

Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors

Maiese¹

2018

CNR

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BACKGROUND With the global increase in life span expectancy, neurodegenerative disorders continue to affect an ever increasing number of individuals throughout the world. New treatment strategies for neurodegenerative diseases are desperately required given the lack of current treatment modalities. METHODS Here we examine novel strategies for neurodegenerative disorders that include circadian clock genes, non-coding ribonucleic acids (RNAs), and the mammalian forkhead transcription factors of the O class (FoxOs). RESULTS Circadian clock genes, non-coding RNAs, and FoxOs offer exciting prospects to potentially limit or remove the significant disability and death associated with neurodegenerative disorders. Each of these pathways have an intimate relationship with the programmed death pathways of autophagy and apoptosis and share a common link to the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) and the mechanistic target of rapamycin (mTOR). Circadian clock genes are necessary to modulate autophagy, limit cognitive loss, and prevent neuronal injury. Non-coding RNAs can control neuronal stem cell development and neuronal differentiation and offer protection against vascular disease such as atherosclerosis. FoxOs provide exciting prospects to block neuronal apoptotic death and to activate pathways of autophagy to remove toxic accumulations in neurons that can lead to neurodegenerative disorders. CONCLUSIONS Continued work with circadian clock genes, non-coding RNAs, and FoxOs can offer new prospects and hope for the development of vital strategies for the treatment of neurodegenerative diseases. These innovative investigative avenues have the potential to significantly limit disability and death from these devastating disorders.

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Influence of age-related learning and memory capacity of mice: different effects of a high and low caloric diet

Cited by 49 publications

References 44 publications

Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women

Chronic purple grape juice consumption induces age-dependent changes on cognitive function in elderly women

Calorie restriction in rodents: Caveats to consider

Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors

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