Influence of age on the prevalence and components of the metabolic syndrome and the association with cardiovascular disease

Abstract

ObjectiveThe significance of the metabolic syndrome (MS) is debated. We investigated whether MS component (by ATPIII and IDF definitions) clustering and any association between MS and prevalent cardiovascular disease (CVD) varied with age.Research design and methodsIn all, 1429 adults (≥25 years) from randomly selected households in rural Victoria, Australia, were assessed for components of MS and prevalent CVD. The expected prevalence of MS was calculated following a simple probabilistic model using the prevalence of each MS component.ResultsThe observed prevalence of MS was greater than expected: 27.0% vs 21.2% (ATPIII) and 36.0% vs 30.1% (IDF; p<0.0001), based on the prevalence of individual components. There was significant clustering of 4 and 5 MS components in participants <65 years (p<0.0001). CVD was more prevalent in MS participants, 13.5% (IDF), 14.5% (ATPIII) versus 5.3% (no MS) p<0.0001. The OR for CVD in MS participants was greatest in those <45 years OR (95% CI): IDF 17.5 (1.8 to 172); ATPIII 24.3(2.4 to 241), p<0.001 for both, and was not significant in those >65 years. The prevalence of MS (ATPIII) with normal waist circumference (WC) was less than expected (4.8% vs 7.9%, p<0.002). Low levels of high-density lipoprotein and high triglyceride were less common in older MS participants.ConclusionsATPIII MS is rare among those with a normal WC. MS components cluster most markedly among those aged <65 years, who also experience substantially greater rates of CVD. Younger patients with MS may warrant more aggressive CVD preventative treatment than suggested by the summation of their individual risk factors.

<p>The Relationship Between Abdominal Body Composition and Metabolic Syndrome After a Weight Reduction Program in Adult Men with Obesity</p>

“…Although MetS prevalence is correlated with age, the association between MetS and cardiovascular risk is noted across age strata. 48,49 In the present study, the effect of IAFA reduction on MetS reversion was independent of age. Third, in order to keep all subjects in a similar lifestyle, we did not design a conventional treatment as controls, and we performed a fixed program regardless of participants' baseline conditions.…”

Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China

“…Some studies showed that the risk of MS increases with age [30], so the variable of age should be adjusted for in risk factor analysis. Central obesity, elevated TG, reduced HDL-C, elevated blood pressure, and elevated fasting glucose are clinical symptoms of MS.…”

Síndrome metabólica em idosos assistidos na atenção terciária à saúde em Curitiba, Paraná: prevalência e associação com saúde, capacidade funcional, estilo de vida e fatores sociodemográficos

“…O aumento da prevalência da SM com o avançar da idade é fato frequentemente citado na literatura, mas é importante observar que em vários desses estudos [36][37][38][39][40][41] as faixas etárias analisadas incluíram os idosos como um grupo homogêneo, com idades a partir de 60 ou 65 anos, e geralmente comparados a faixas etárias inferiores. Ao analisar os subgrupos etários como no presente estudo (idosos mais jovens com…”