Influence of Age, Morphological Characteristics, and Lumbar Spine Bone Mineral Density on Lumbar Spine Trabecular Bone Score in Lebanese Women

Hage, Rawad El; Khairallah, Walid; Bachour, Falah; Issa, Majed; Eid, Roy; Fayad, Fouad; Yared, Christine; Zakhem, Eddy; Adib, Gemma; Maalouf, Ghassan

doi:10.1016/j.jocd.2013.03.012

Cited by 31 publications

(12 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Age related declines in LS BMD and TBS were also observed in a large cross-sectional study of 29,407 women ≥ 50 years from the province of Manitoba, Canada (22). Similarly, a negative correlation between L2-L4 TBS and age (r = -0.39, p < 0.001) was observed in 4,907 Lebanese women from 20 to 90 years of age (23).…”

Section: Relationship Of Tbs With Age and Major Clinical Risk Factorsmentioning

confidence: 56%

Trabecular bone score: perspectives of an imaging technology coming of age

Silva

Bilezikian

2014

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

The trabecular bone score (TBS) is a new method to describe skeletal microarchitecture from the dual energy X-ray absorptiometry (DXA) image of the lumbar spine. While TBS is not a direct physical measurement of trabecular microarchitecture, it correlates with micro-computed tomography (µCT) measures of bone volume fraction, connectivity density, trabecular number, and trabecular separation, and with vertebral mechanical behavior in ex vivo studies. In human subjects, TBS has been shown to be associated with trabecular microarchitecture and bone strength by high resolution peripheral quantitative computed tomography (HRpQCT). Cross--sectional and prospective studies, involving a large number of subjects, have both shown that TBS is associated with vertebral, femoral neck, and other types of osteoporotic fractures in postmenopausal women. Data in men, while much less extensive, show similar findings. TBS is also associated with fragility fractures in subjects with secondary causes of osteoporosis, and preliminary data suggest that TBS might improve fracture prediction when incorporated in the fracture risk assessment system known as FRAX. In this article, we review recent advances that have helped to establish this new imaging technology. Arq Bras Endocrinol Metab. 2014;58(5):493-503 Keywords Trabecular bone score; osteoporosis; fracture risk; bone mineral density; microarchitecture RESUMO TBS (do inglês, "trabecular bone score") é um novo método que estima a microarquitetura óssea a partir de uma imagem de densitometria óssea (DXA) da coluna lombar. Apesar de o TBS não ser uma medida física direta da microarquitetura trabecular, ele correlaciona-se com o volume ósseo, densidade da conectividade trabecular, número de trabéculas e separação trabecular medidos por microtomografia computadorizada (µCT), e com medidas mecânicas da resistência óssea vertebral em estudos ex vivo. Estudos em humanos confirmaram que o TBS associa-se a microarquitetura trabecular e resistência óssea medidas por tomografia computadorizada quantitativa periférica de alta resolução (HRpQCT). Estudos transversais e prospectivos, envolvendo um grande número de indivíduos, mostraram que o TBS é associado com fratura vertebral, de colo de fêmur e com outros tipos de fraturas osteoporóticas em mulheres na pós-menopausa. Dados em homens, apesar de escassos, mostram resultados semelhantes. Além disso, o TBS foi associado a fraturas por fragilidade em indivíduos com diversas causas secundárias de osteoporose e, dados preliminares, sugerem que o uso do TBS pode melhorar a previsão de fratura quando incorporado ao sistema de avaliação de risco de fratura (FRAX). Este artigo faz uma revisão de avanços recentes que têm ajudado a estabelecer esse novo mé-todo de imagem. Arq Bras Endocrinol Metab. 2014;58(5):493-503 Descritores

show abstract

Section: Relationship Of Tbs With Age and Major Clinical Risk Factorsmentioning

confidence: 56%

Trabecular bone score: perspectives of an imaging technology coming of age

Silva

Bilezikian

2014

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…(51) In agreement with these reports, a cross-sectional study showed parallel age-related declines in LS BMD and TBS in 29,407 women !50 years from the Canadian province of Manitoba referred for baseline BMD evaluation. (53) Similarly, El Hage and colleagues (54) showed a negative correlation between L 2 to L 4 TBS and age (r ¼ -0.39, p < 0.001) in 4907 Lebanese women aged 20 to 90 years.…”

Section: Age As An Important Factor In Tbsmentioning

confidence: 88%

Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image

Silva

Leslie

Resch³

et al. 2014

Journal of Bone and Mineral Research

662

487

View full text Add to dashboard Cite

The trabecular bone score (TBS) is a gray-level textural metric that can be extracted from the two-dimensional lumbar spine dualenergy X-ray absorptiometry (DXA) image. TBS is related to bone microarchitecture and provides skeletal information that is not captured from the standard bone mineral density (BMD) measurement. Based on experimental variograms of the projected DXA image, TBS has the potential to discern differences between DXA scans that show similar BMD measurements. An elevated TBS value correlates with better skeletal microstructure; a low TBS value correlates with weaker skeletal microstructure. Lumbar spine TBS has been evaluated in cross-sectional and longitudinal studies. The following conclusions are based upon publications reviewed in this article: 1) TBS gives lower values in postmenopausal women and in men with previous fragility fractures than their nonfractured counterparts; 2) TBS is complementary to data available by lumbar spine DXA measurements; 3) TBS results are lower in women who have sustained a fragility fracture but in whom DXA does not indicate osteoporosis or even osteopenia; 4) TBS predicts fracture risk as well as lumbar spine BMD measurements in postmenopausal women; 5) efficacious therapies for osteoporosis differ in the extent to which they influence the TBS; 6) TBS is associated with fracture risk in individuals with conditions related to reduced bone mass or bone quality. Based on these data, lumbar spine TBS holds promise as an emerging technology that could well become a valuable clinical tool in the diagnosis of osteoporosis and in fracture risk assessment.

show abstract

“…Нельзя также использовать различные денситометры. Искажать результат мо-жет и развитая подкожно-жировая клетчатка перед-ней брюшной стенки, поэтому оценку TBS лучше проводить при ИМТ 15-35 кг/м 2 [26]. В нашем ис-следовании суммарный результат не зависел от включения в анализ пациентов с ИМТ >35 кг/м 2 , хотя развитый подкожно-жировой слой передней брюшной стенки, характерный для пациентов с ЭГ, мог играть роль «артефакта».…”

Section: Discussionunclassified

“…В нашем ис-следовании суммарный результат не зависел от включения в анализ пациентов с ИМТ >35 кг/м 2 , хотя развитый подкожно-жировой слой передней брюшной стенки, характерный для пациентов с ЭГ, мог играть роль «артефакта». У пациентов без вто-ричного остеопороза TBS снижается с возрастом [26]. Эта тенденция не наблюдается при вторичном остеопорозе.…”

Section: Discussionunclassified

Trabecular bone score as one of the new methods of non-invasive evaluation of bone microarchitecture in patients with Cushing’s syndrome

Dragunova¹,

Вячеславовна²,

Belaya³

et al. 2015

Probl Endokrinol (Mosk)

View full text Add to dashboard Cite

Objective - to evaluate the value of trabecular bone score and risk factors of fractures in patients with Cushing’s syndrome (CS). Material and methods. One hundred eighty two patients with laboratory-confirmed Cushing’s syndrome were enrolled. All patients underwent measurement of bone mineral density (BMD) at the lumbar spine (LI-LIV), femoral neck and total hip using DXA Prodigy (GEHC Lunar, Madison, WI, USA). Trabecular bone score (TBS) was assessed retrospectively on the basis of already existing DXA images using software TBS iNsight software v2.1 (Medimaps, Merignac, France). Each patient was interviewed for the presence of low-traumatic fractures during the active stage of the disease. A lateral X-ray of the thoracic and lumbar spine ThIV-LV was performed to estimate vertebral fractures. Twenty-four hours urinary free cortisol (24hUFC) was measured by imunochemiluminescence assay VITROS ECi with the preliminary extraction with diethyl ether (reference values 60-413 nmol/24 h). Results. Among 182 patients with CS (149 women, 33 men), Cushing’s disease was confirmed in 151 cases, 9 patients diagnosed with benign adrenal tumor and 22 - ACTH-ectopic syndrome. The median of age - 35 (Q25-Q75 27-49) years, body mass index - 29 (26-33) kg/m2, 24hUFC - 1760 (985-2971) nmol/24h. Fractures were confirmed in 80 (44%) cases, 70 patients suffered from vertebral fractures, which were multiple in 53 cases; 23 patients had non-vertebral fractures. Median of trabecular bone score was 1.205 (1.102-1.307), which is much lower than expected in healthy volunteers (>1.350), while the decrease in bone mineral density (BMD) did not correspond to the severity and prevalence of osteoporosis fractures: LI-LIV Z-score - 1.7 (2.5-0.73); femoral neck Z-score - 1 (-1.6- -0.4). However, when using binary logistic regression analysis (adjusted for sex, age, body mass index, bone mineral density, trabecular bone score and 24hUFC) revealed that the most significant predictor of fracture is high levels of 24hUFC (p=0.001) . The high prevalence of vertebral fractures in patients with CS most likely influenced the results of trabecular bone score and its ability to predict fractures. Conclusion. Patients with active CS have low trabecular bone score, rather than bone mineral density, which reflects deterioration in bone microarchitecture. The low-traumatic fracture occurrence depends on the severity of CS reflected in 24hUFC levels.

show abstract

Influence of Age, Morphological Characteristics, and Lumbar Spine Bone Mineral Density on Lumbar Spine Trabecular Bone Score in Lebanese Women

Cited by 31 publications

References 12 publications

Trabecular bone score: perspectives of an imaging technology coming of age

Trabecular bone score: perspectives of an imaging technology coming of age

Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image

Trabecular bone score as one of the new methods of non-invasive evaluation of bone microarchitecture in patients with Cushing’s syndrome

Contact Info

Product

Resources

About