Influence of age and gender on dose and effectiveness of botulinum toxin for laryngeal dystonia

Abstract

Dosage and duration of beneficial effect of botulinum toxin in treatment of adductor laryngeal dystonia do not appear to vary with age or gender.

Botulinum toxin treatment of adductor spasmodic dysphonia: Longitudinal functional outcomes

“…In our population, dosing varies widely between patients. As in other dystonias, we find that BoNT dose in AdSD is not related to either sex or age 20. Furthermore, we observe that each patient's symptoms and dose tend to vary over time.…”

Gender differences in onabotulinum toxin A dosing for adductor spasmodic dysphonia

“…This retrospective chart review reveals a statistically and clinically significant correlation between female gender and higher average BoNTA dose for symptom control in adductor SD. Vasconcelos et al conducted a retrospective review with a slightly smaller cohort examining the influence of age and gender on dosing effectiveness of botulinum toxin (BTX) for laryngeal dystonia . Their hypothesis was that the average BTX dose for males would be greater than for females due to the increased male muscle volume and therefore greater number of neuromuscular junctions for BoNTA to act upon.…”

“…conducted a retrospective review with a slightly smaller cohort examining the influence of age and gender on dosing effectiveness of botulinum toxin (BTX) for laryngeal dystonia. 7 Their hypothesis was that the average BTX dose for males would be greater than for females due to the increased male muscle volume and therefore greater number of neuromuscular junctions for BoNTA to act upon. Their results, however, were to the contrary and revealed a higher dose for the female (2.15 U) versus male group (1.85 U).…”

Dystonia of the Oromandibular, Lingual and Laryngeal Areas

“…52 The first BoNT toxin injection for the treatment of laryngeal dystonia was given by Biltzer in 1984 and since then BoNT injection has become the main treatment modality. 53 For adductor laryngeal dystonia, injection of one or both of the thyroarytenoid muscles is performed. Using EMG, a needle is passed through the cricothyroid membrane in the midline and is angled superior lateral in the direction of the thyroarytenoid muscles.…”