Influence of a multiple emulsion, liposomes and a microemulsion gel on sebum, skin hydration and TEWL

Mahrhauser, Denise-Silvia; Nagelreiter, C.; Baierl, Andreas; Skipiol, J.; Valenta, Claudia

doi:10.1111/ics.12180

Cited by 29 publications

(24 citation statements)

References 13 publications

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“…We compared skin biophysical parameters and bacterial communities in facial cheek skins with different hydration levels (HHG and LHG). TEWL in HHG was lower than that in LHG (Figure ), in accordance with a previous study (Mahrhauser, Nagelreiter, Baierl, Skipiol, & Valenta, ). Facial skin roughness was not significantly different depending on the skin hydration level (Figure ).…”

Section: Discussionsupporting

confidence: 92%

Effects of cosmetics on the skin microbiome of facial cheeks with different hydration levels

Lee

Jeong

Lee³

et al. 2017

MicrobiologyOpen

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Basic cosmetics was used by volunteers belonging to high (HHG) and low (LHG) hydration groups for 4 weeks, and bacterial communities and biophysical parameters in facial skin were analyzed. Hydration level increases and transepidermal water loss and roughness decreases were observed in both groups after cosmetic use. Bacterial diversity was greater in LHG than HHG, and increased after cosmetic use in both groups. Bray–Curtis dissimilarities that were higher in LHG than HHG increased in HHG after cosmetic use, whereas they decreased in LHG. The phyla Actinobacteria, Proteobacteria, Firmicutes, and Bacteroidetes and the genera Propionibacterium, Ralstonia, Burkholderia, Staphylococcus, Corynebacterium, Cupriavidus, and Pelomonas were identified as common groups and they were not significantly different between LHG and HHG except for Propionibacterium that was more abundant in HHG. After cosmetic use, Propionibacterium, Staphylococcus, and Corynebacterium decreased, whereas Ralstonia, not a core genus, increased, as did KEGG categories of lipid metabolism and xenobiotics biodegradation and metabolism, suggesting that Ralstonia in skin may have the ability to metabolize cosmetics components. Bacterial communities after cosmetic use were different from those in both LHG and HHG before the cosmetic use, indicating that bacterial communities in LHG were not shifted to resemble those in HHG by cosmetics use.

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Section: Discussionsupporting

confidence: 92%

Effects of cosmetics on the skin microbiome of facial cheeks with different hydration levels

Lee

Jeong

Lee³

et al. 2017

MicrobiologyOpen

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“…Measurement of TEWL parameter is often used to estimate the changes in skin barrier function . The obtained results showed that both samples (EM and PL) led to a little increase in the value of TEWL after 14 or 28 days compared to baseline, but without statistical significance ( P > 0.05).…”

Section: Resultsmentioning

confidence: 92%

Standardized extract of wild apple fruit in alkyl‐polyglucoside‐based cosmetic cream – estimation of stability, safety, antioxidant activity and efficiency

Stojiljković¹,

Tadić

Stanković

et al. 2018

Intern J of Cosmetic Sci

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Investigated cosmetic cream was pale beige color, odorless, semi-solid consistency and homogeneous, with pH values of 6.53±0.14, electrical conductivity above 50 μS/cm and AA of 24.96%RSC after preparation and these characteristics were stable during investigated period. In vivo measurements revealed absence of skin irritation after cream application under occlusion, which was part of it's safety profile. Increase of skin hydration after 14 days of cream application was 17.28±12.23 and after 28 days 21.19±7.59. In addition, in performed experiment TEWL and skin pH values during cream application remained unchanged. Cream application after artificial hyperpigmentation induced decrease of MI (∆MI after 7 days was -45.30±18.55) CONCLUSION: Formulated cosmetic cream with 6% of standardized wild apple fruit water extract and stabilized by biodegradable alkyl-polyglucoside emulsifiers demonstrated good stability, acceptable level of in vitro antioxidant activity, absence of skin irritation after cream application under occlusion and positive effects of cream on human skin after application (hydrating and bleaching effects). All mentioned properties make the cream suitable for possible usage as cosmetic product for preventing the skin damages caused by oxidative stress, for moisturizing the dry skin and bleaching of skin hyperpigmentation. This article is protected by copyright. All rights reserved.

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“…TEWL value is regarded as one of the most important parameters for skin barrier function. [15] TEWL is a measure of the flux density of condensed water diffusing from the deeper highly hydrated layers of the dermis and epidermis to the skin surface. TEWL values are affected by the state and function of the stratum corneum (SC).…”

Section: Discussionmentioning

confidence: 99%

Atopic Dermatitis-like Graft-versus-host Disease and Lichen Planus-like Graft-versus-host Disease

Chen

et al. 2017

Chinese Medical Journal

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Background:Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplantation. Skin barrier disruption could induce thymic stromal lymphopoietin (TSLP) expression, and the expression of TSLP was increased in lesions of atopic dermatitis (AD)-like GVHD and lichen planus (LP)-like GVHD. This study attempted to investigate the skin barrier function of AD-like GVHD and LP-like GVHD and possible mechanisms.Methods:Eighteen AD-like GVHD patients, 12 LP-like GVHD patients, and 14 healthy volunteers were enrolled in this study. Skin biopsy was done in five AD-like GVHD patients, eight LP-like GVHD patients, and eight healthy volunteers. The intensity of pruritus was assessed by visual analog scale itch score and detailed pruritus score. Transepidermal water loss (TEWL) was measured using Tewameter® TM 300. Immunohistochemistry was used to observe the expression of loricrin, involucrin, LL37, and human β-defensins 2 (hBD2) in skin lesions. Western blot analysis was used for analyzing the protein levels of loricrin and involucrin in skin lesions. Real-time polymerase chain reaction was performed to assess the mRNA levels of LL37 and hBD2 in skin lesions.Results:Pruritus score was higher in patients with AD-like GVHD (11.33 ± 5.35) than that of patients with LP-like GVHD (2.58 ± 3.09, P < 0.001). Compared with healthy controls (HCs, 4.52 ± 1.24 g·m−2·h−1), TEWL was increased in AD-like GVHD (26.72 ± 9.02 g·m−2·h−1, P < 0.001) and LP-like GVHD patients (18.78 ± 4.57 g·m−2·h−1, P < 0.001), and expressions of loricrin and involucrin were also increased in skin lesions of AD-like GVHD and LP-like GVHD patients (all P < 0.05). LL37 mRNA expression was decreased in lesions of AD-like GVHD and LP-like GVHD patients (P = 0.005 and P = 0.008, vs. HCs, respectively). hBD2 mRNA expression was increased in skin lesions of AD-like GVHD and LP-like GVHD patients (P = 0.002 and P < 0.001, vs. HCs, respectively).Conclusions:Skin barrier dysfunction is present in AD-like GVHD and LP-like GVHD. The immunoreactions, but not the congenital defect, are considered to be the primary cause of skin barrier impairment in AD-like GVHD and LP-like GVHD.

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Influence of a multiple emulsion, liposomes and a microemulsion gel on sebum, skin hydration and TEWL

Cited by 29 publications

References 13 publications

Effects of cosmetics on the skin microbiome of facial cheeks with different hydration levels

Effects of cosmetics on the skin microbiome of facial cheeks with different hydration levels

Standardized extract of wild apple fruit in alkyl‐polyglucoside‐based cosmetic cream – estimation of stability, safety, antioxidant activity and efficiency

Atopic Dermatitis-like Graft-versus-host Disease and Lichen Planus-like Graft-versus-host Disease

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