Influence of a low‐dose supplementation of curcumagalactomannoside complex (<scp>CurQfen</scp>) in knee osteoarthritis: A randomized, open‐labeled, active‐controlled clinical trial

Thomas, Jestin V.; Smina, T P; Khanna, Aman; Kunnumakkara, Ajaikumar B.; Maliakel, Balu; Mohanan, Ratheesh; Krishnakumar, I. M.

doi:10.1002/ptr.6907

Cited by 25 publications

(19 citation statements)

References 48 publications

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“…Many studies demonstrated that oral administration of CS improved human knee joint pains [ 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 ]. Even though glucosamine has been commercialized as a dietary supplement, oral CS bioavailability remains speculative, and conflicting results are found in the scientific literature.…”

Section: Prospective Pharmacological Applicationmentioning

confidence: 99%

A Concise Review of Extraction and Characterization of Chondroitin Sulphate from Fish and Fish Wastes for Pharmacological Application

Urbi

Azmi

Ming

et al. 2022

CIMB

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Chondroitin sulphate (CS) is one of the most predominant glycosaminoglycans (GAGs) available in the extracellular matrix of tissues. It has many health benefits, including relief from osteoarthritis, antiviral properties, tissue engineering applications, and use in skin care, which have increased its commercial demand in recent years. The quest for CS sources exponentially increased due to several shortcomings of porcine, bovine, and other animal sources. Fish and fish wastes (i.e., fins, scales, skeleton, bone, and cartilage) are suitable sources of CS as they are low cost, easy to handle, and readily available. However, the lack of a standard isolation and characterization technique makes CS production challenging, particularly concerning the yield of pure GAGs. Many studies imply that enzyme-based extraction is more effective than chemical extraction. Critical evaluation of the existing extraction, isolation, and characterization techniques is crucial for establishing an optimized protocol of CS production from fish sources. The current techniques depend on tissue hydrolysis, protein removal, and purification. Therefore, this study critically evaluated and discussed the extraction, isolation, and characterization methods of CS from fish or fish wastes. Biosynthesis and pharmacological applications of CS were also critically reviewed and discussed. Our assessment suggests that CS could be a potential drug candidate; however, clinical studies should be conducted to warrant its effectiveness.

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Section: Prospective Pharmacological Applicationmentioning

confidence: 99%

A Concise Review of Extraction and Characterization of Chondroitin Sulphate from Fish and Fish Wastes for Pharmacological Application

Urbi

Azmi

Ming

et al. 2022

CIMB

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show abstract

“…After screening the titles and abstracts of the remaining 263 citations, we excluded 233 irrelevant records based on the selection criteria. Thirty studies were remained for full-text assessment, eleven studies were excluded because of ineligible interventions, including the combination of glucosamine hydrochloride, chondroitin sulphate and curcumin [ 41 ], curcumagalactomannoside complex [ 42 , 43 ], CURs combined with diclofenac [ 44 , 45 ], herbal formulations of different extracts [ 46 – 50 ], and CURs-free CL extracts [ 51 ]. Furthermore, we excluded four conference abstracts [ 52 – 55 ] due to incomplete data.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

Feng

Tian

et al. 2022

BMC Complement Med Ther

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Background Curcuminoids (CURs) are the principal ingredients of Curcuma longa L. [Zingiberaceae] (CL)—an herbal plant used in east Asia to alleviate pain and inflammation. Thus far, the therapeutic effects of CURs for knee osteoarthritis (OA) uncovered by multiple reviews remained uncertain due to broadly involving trials with different agents-combined or CURs-free interventions. Therefore, we formed stringent selection criteria and assessment methods to summarize current evidence on the efficacy and safety of CURs alone in the treatment of knee OA. Methods A series of databases were searched for randomized controlled trials (RCTs) evaluating the efficacy and safety of CURs for knee OA. Clinical outcomes were evaluated using meta-analysis and the minimum clinically important difference (MCID) for both statistical and clinical significance. Results Fifteen studies with 1670 patients were included. CURs were significantly more effective than placebo in the improvements of VAS for pain ( WMD: − 1.77, 95% CI: − 2.44 to − 1.09), WOMAC total score ( WMD: − 7.06, 95% CI: − 12.27 to − 1.84), WOMAC pain score ( WMD: − 1.42, 95% CI: − 2.41 to − 0.43), WOMAC function score ( WMD: − 5.04, 95% CI: − 7.65 to − 2.43), and WOMAC stiffness score ( WMD: − 0.54, 95% CI: − 1.03 to − 0.05). Meanwhile, CURs were not inferior to NSAIDs in the improvements of pain- and function-related outcomes. Additionally, CURs did not significantly increase the incidence of adverse events (AEs) compared with placebo ( RR: 1.03, 95% CI: 0.69 to 1.53, P = 0.899, I2 = 23.7%) and NSAIDs (RR: 0.71 0.65, 95% CI: 0.57 0.41 to 0.90 1.03). Conclusions CURs alone can be expected to achieve considerable analgesic and functional promotion effects for patients with symptomatic knee OA in short term, without inducing an increase of adverse events. However, considering the low quality and substantial heterogeneity of present studies, a cautious and conservative recommendation for broader clinical use of CURs should still be made. Further high-quality studies are necessary to investigate the impact of different dosages, optimization techniques and administration approaches on long-term safety and efficacy of CURs, so as to strengthen clinical decision making for patients with symptomatic knee OA.

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“…After screening the titles and abstracts of the remaining 291 citations, we excluded 262 irrelevant records based on the selection criteria. Twentynine studies were remained for full-text assessment, eleven studies were excluded because of ineligible interventions, including the combination of glucosamine hydrochloride, chondroitin sulphate and curcumin [42], curcumagalactomannoside complex [43,44], CURs combined with diclofenac [45,46], herbal formulations of different extracts [47][48][49][50][51], and CURs-free CL extracts [52]. Furthermore, we excluded four conference abstracts [53][54][55][56] due to incomplete data.…”

Section: Literature Search Resultsmentioning

confidence: 99%

Clinical Significance of Curcuminoids Alone in Alleviating Pain and Dysfunction for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Feng

Tian

et al. 2022

Preprint

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Background: Curcuminoids (CURs) are the principal ingredients of Curcuma longa L. [Zingiberaceae] (CL)—an herbal plant used in east Asia to alleviate pain and inflammation. Thus far, the therapeutic effects of CURs for knee osteoarthritis (OA) uncovered by multiple reviews remained uncertain due to broadly involving trials with different agents-combined or CURs-free interventions. Therefore, we formed stringent selection criteria and assessment methods to summarize current evidence on the effectiveness of CURs alone in the treatment of knee OA.Methods: A series of databases were searched for randomized controlled trials (RCTs) evaluating the efficacy of CURs for knee OA. Clinical outcomes were evaluated using meta-analysis and the minimum clinically important difference (MCID) for both statistical and clinical significance.Results: Fourteen studies with 1633 patients were included. Overall, CURs were significantly more effective than controls in the improvements of VAS for pain (WMD: −1.46, 95% CI: −2.13 to −0.8), WOMAC total score (WMD: −7.06, 95% CI: −12.27 to −1.84), WOMAC pain score (WMD: −1.42, 95% CI: −2.41 to −0.43), WOMAC function score (WMD: −5.04, 95% CI: −7.65 to −2.43), but not in WOMAC stiffness score (WMD: −0.34, 95% CI: −0.79 to 0.1). Moreover, the effect sizes of VAS for pain and WOMAC total score exceeded their MCID, while WOMAC subscale scores did not. Additionally, CURs did not significantly increase the incidence of adverse events (AEs) compared with placebo (RR: 1.22, 95% CI: 0.89 to 1.67), and significantly lowered the incidence of AEs when compared with NSAIDs (RR: 0.71, 95% CI: 0.59 to 0.9).Conclusions: CURs alone can be expected to achieve considerable analgesic and functional promotion effects for patients with symptomatic knee OA in short term, without inducing an increase of adverse events. However, considering the low quality and substantial heterogeneity of present studies, a cautious and conservative recommendation for broader clinical use of CURs should still be made. Further high-quality studies are necessary to investigate the impact of different dosages, optimization techniques and administration approaches on long-term safety and efficacy of CURs, so as to strengthen clinical decision making for patients with symptomatic knee OA.

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Influence of a low‐dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open‐labeled, active‐controlled clinical trial

Cited by 25 publications

References 48 publications

A Concise Review of Extraction and Characterization of Chondroitin Sulphate from Fish and Fish Wastes for Pharmacological Application

A Concise Review of Extraction and Characterization of Chondroitin Sulphate from Fish and Fish Wastes for Pharmacological Application

Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

Clinical Significance of Curcuminoids Alone in Alleviating Pain and Dysfunction for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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