Influence du Cobalt sur la Consommation D'oxygène des Rats Blancs Adultes

A Comparison of the Cobalt, Methylene Blue, Zinc, Arsenite and Amino Triazole Effect on Erythropoietin Production

“…The respiration is decreased after cobalt as shown for the animal organism as a whole (Wesley, 1956 Wiberg, 1968) ; for cells in tissue culture (Daniel et al, 1963) and for isolated mitochondria Wiberg et al, 1967;Csillag, 1971). This decreased oxygen uptake, in connection with an undisturbed oxygen transport in the organism (no methaemoglobin formation) (Bucciero & Orten, 1949) and no influence on the O2 dissociation curve (Panayotopoulos et al, 1962), is no doubt responsible for the increase in tissue oxygen tension observed after administration of cobalt (Thorling & Erslev, 1972).…”

“…The cellular uptake of oxygen is, however, severely hampered by cobalt (Hearon et al, 1947;Wesley, 1956; Daniel et al, 1963;Dingle et af, 1962;Yastrebov, 1966; Moraes & Mariano, 1967; Wiberg, 1968;Miller & Hayle, 1970) and, therefore, one might more appropriately describe the effect to a cell toxicity, probably inter alia interfering with the oxidative metabolism. The specific action of cobalt is, however, largely unknown, and cyanide which also is a powerful inhibitor of the oxidative metabolism has no effect whatsoever on erythropoietin production even when given in sublethal doses (NeEas & Thorling, 1972). In order possibly to elucidate the specific mechanisms which must be effected in order to generate the 'impulse' necessary for the stimulation of erythropoietin production, the known biochemical effects of cobalt were compared to those of other inorganic compounds.…”