Infliximab Reduces Myeloperoxidase Concentration in Chronic Inflammatory Joint Diseases

Abstract

The present study evaluated the effect of infliximab on the myeloperoxidase (MPO) concentration in chronic inflammatory joint disease. Eighteen patients were divided into active and inactive groups. Erythrocyte sedimentation rate, C-reactive protein, white blood cell counts, MPO concentration, and biomarkers of oxidative stress were measured before and after the infusion of infliximab. Patients with active disease showed increases in concentrations of MPO and biomarkers of oxidation, but decreases in antioxidant parameters. After infliximab treatment, both inflammatory parameters and MPO concentrations were normalized. In conclusion: (1) the MPO concentration is related to inflammatory activity and could play an important role in the maintenance and outbreak of oxidative stress present in these diseases, and (2) infliximab inhibits MPO concentration.

Treatment of Toxic Epidermal Necrolysis with the Combination of Infliximab and High-Dose Intravenous Immunoglobulin

“…MPO has dual destructive actions in tissues: (a) enzymatically active MPO is a potent effector of cell killing, and (b) enzymatically inactive MPO induces macrophages to produce pro-inflammatory cytokines, including TNFα [23]. Treatment with infliximab has been reported to reduce MPO concentrations in the circulation of patients with inflammatory joint conditions [24,25], a finding indicative of the potential contribution of MPO inhibition to the observed efficacy of anti-TNFα therapeutic strategies in patients with TEN that requires further investigation. The addition of IVIg in the treatment scheme targets the Fas-Fas ligand-mediated keratinocyte apoptosis [4] and potentially enhances removal of TNFα, soluble Fas ligand and probably also of the incriminated drugs from the circulation [2,26].…”

NGF and nitrosative stress in patients with Huntington's disease

“…As indicated earlier, there is a strong link between oxidative stress, the activity of the immune system -particularly phagocyte burstand production of MPO, a pro-oxidant enzyme present in polymorphonuclear WBCs, which is able to generate reactive species that damage lipids and proteins; MPO has been linked to neurodegenerative processes [27] and other kinds of autoimmune-inflammatory disorder including ankylosing spondylitis and rheumatoid arthritis [28].…”

The Anti-Inflammatory Fungal Compound (S)-Curvularin Reduces Proinflammatory Gene Expression in an In Vivo Model of Rheumatoid Arthritis

“…Reactive oxygen species, as a second messenger, can activate NF-B and thus promote the onset and progression of arthritis (Miesel et al, 1996). In chronic inflammatory joint diseases, elevated levels of MPO were detected (Mä ki-Petäjä et al, 2008;Feijóo et al, 2009). In the study of Mä ki-Petäjä et al (2008), MPO levels correlated positively with the amount of the inflammation marker C-reactive protein and iNOS activity and negatively with the endothelial function.…”