2012
DOI: 10.1124/jpet.112.192047 View full text |Buy / Rent full text
|
|

Abstract: In previous studies, we identified the fungal macrocyclic lactone (S)-curvularin (SC) as an anti-inflammatory agent using a screening system detecting inhibitors of the Janus kinase/signal transducer and activator of transcription pathway. The objective of the present study was to investigate whether SC is able to decrease proinflammatory gene expression in an in vivo model of a chronic inflammatory disease. Therefore, the effects of SC and dexamethasone were compared in the model of collagen-induced arthritis… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
2
1
1
1
0
27
0

Year Published

2013
2013
2017
2017

Publication Types

Select...
4

Relationship

2
2

Authors

Journals

0
27
0
Order By: Relevance
“…As shown in Fig. 5E (26). Compared with PBStreated mice we observed reduced TTP and enhanced Nox2 mRNA expression in the paws of CII-treated mice (Fig.…”
Section: Increased Nox2 Expression In Ttp-deficient Mice Correlates Wmentioning
See 1 more Smart Citation
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 14 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 100,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…As shown in Fig. 5E (26). Compared with PBStreated mice we observed reduced TTP and enhanced Nox2 mRNA expression in the paws of CII-treated mice (Fig.…”
Section: Increased Nox2 Expression In Ttp-deficient Mice Correlates Wmentioning
“…Induction of CIA and Measurement of mRNA Expression in Paws-CIA induction in V␤12-DBA/1 mice, RNA isolation, and mRNA expression analyses were performed as described (26). mRNA expression of TTP and Nox2 in paws of PBS-or chicken CII-treated animals was analyzed at day 33 after the first CII treatment.…”
Section: Methodsmentioning
“…S1A), suggesting a potential role in immune regulatory responses. Additionally, GPSM3 mRNA was recently shown to decrease in the paw after anti-inflammatory treatment with dexamethasone in the Collagen Induced Arthritis (CIA) model (7), supporting a potential role for GPSM3 in inflammatory arthritis.…”
Section: Introductionmentioning
“…The location of the Gpsm3 gene within the class III major histocompatibility class locus suggested that AGS4/Gpsm3 is expressed primarily in the immune system, and initial observations from us and others indicated this was indeed the case (Cao et al, 2004;Kimple et al, 2004;Zhao et al, 2010;Schmidt et al, 2012;Giguère et al, 2013). We also discovered AGS4 expression in primary bone marrow-derived dendritic cells and splenocytes (Fig.…”
Section: Resultsmentioning