Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

Wang, Jun; Tang, Wei; Yang, Meng; Yin, Ying; Li, Hui; Hu, Fangfang; Tang, Lin; Ma, Xiaoyue; Zhang, Yu; Wang, Yazhou

doi:10.1016/j.biomaterials.2021.120784

Cited by 154 publications

(117 citation statements)

References 74 publications

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“…NEs-Exos have been loaded with doxorubicin (DOX) and in in vivo zebrafish and mouse models of glioma, it has been showed that NE-Exos carrying the drug responded chemotactically to the tumor inflammatory stimuli, rapidly penetrated the BBB, migrated to the brain and targeted infiltrating tumor cells, effectively restraining tumor growth. Based on these results, the authors confirmed that NEs-Exos have a chemotactic function similar to that of neutrophils and are able to cross the BBB, representing a new DOX delivery platform for the treatment of glioma and other solid tumors; however, this also opens the door for NEs-Exos to be used for the treatment of other brain diseases [246]. [272] In recent years, exosomes have also been used experimentally as cancer immunotherapy treatments.…”

Section: Potential Role Of Exosomes In Cancer Treatmentmentioning

confidence: 82%

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

et al. 2021

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Exosomes are extracellular vesicles released by cells, both constitutively and after cell activation, and are present in different types of biological fluid. Exosomes are involved in the pathogenesis of diseases, such as cancer, neurodegenerative diseases, pregnancy disorders and cardiovascular diseases, and have emerged as potential non-invasive biomarkers for the detection, prognosis and therapeutics of a myriad of diseases. In this review, we describe recent advances related to the regulatory mechanisms of exosome biogenesis, release and molecular composition, as well as their role in health and disease, and their potential use as disease biomarkers and therapeutic targets. In addition, the advantages and disadvantages of their main isolation methods, characterization and cargo analysis, as well as the experimental methods used for exosome-mediated drug delivery, are discussed. Finally, we present potential perspectives for the use of exosomes in future clinical practice.

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Section: Potential Role Of Exosomes In Cancer Treatmentmentioning

confidence: 82%

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

et al. 2021

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“…They reported that NEs-Exos penetrate the BBB rapidly and target the tumor site after intravenous injection. NEs-Exos loaded with DOX exhibited significant antitumor efficacy and prolonged the survival of glioma-bearing mice (Wang et al, 2021). Exosomes have a strong cargo-loading capacity, and the delivery potentials of exosomes can be enhanced by loading nanoparticles.…”

Section: Leukocytes-based Vehicles For Brain Tumor Drug Deliverymentioning

confidence: 99%

“…For delivery of drugs for brain diseases therapy, biomimetic drug delivery systems may help increase biocompatibility, long − term circulation and more importantly, penetrate the BBB to increase drug concentration at the target site (Chen et al., 2020 ). The most commonly developed cell-based vehicles for biomimetic drug delivery include living cells (Wang et al., 2015 ), cell membranes (Luk & Zhang, 2015 ), and nanovesicles (Usman et al., 2018 ), depending on the target of disease and cargo for delivery. Cell and cell membrane are similar vehicles for drug delivery by direct loading of drugs or coating drug nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

From blood to brain: blood cell-based biomimetic drug delivery systems

Liu

et al. 2021

Drug Delivery

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Brain drug delivery remains a major difficulty for several challenges including the blood-brain barrier, lesion spot targeting, and stability during circulation. Blood cells including erythrocytes, platelets, and various subpopulations of leukocytes have distinct features such as long-circulation, natural targeting, and chemotaxis. The development of biomimetic drug delivery systems based on blood cells for brain drug delivery is growing fast by using living cells, membrane coating nanotechnology, or cell membrane-derived nanovesicles. Blood cell-based vehicles are superior delivery systems for their engineering feasibility and versatile delivery ability of chemicals, proteins, and all kinds of nanoparticles. Here, we focus on advances of blood cell-based biomimetic carriers for from blood to brain drug delivery and discuss their translational challenges in the future.

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“…This research would not only help provide new drug delivery strategies for the treatment of glioma, but also provide new opportunities for noninvasive targeted drug delivery for other central nervous system diseases. 81…”

Section: Dovepressmentioning

confidence: 99%