Inflammatory thyroid disorders

Sniezek, Joseph C.; Francis, Thomas B.

doi:10.1016/s0030-6665(02)00133-0

Cited by 7 publications

(1 citation statement)

References 97 publications

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“…ACECR.ROYAN.REC.1400.091) and written informed consent was obtained from the patients. Forty patients (25-35 years old) with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with symptoms at least three months have passed since their last ovulation stimulation, body mass index (BMI) >30, without systemic inflammatory diseases, diabetes, hypertension ( Solak et al ., 2016 ) and thyroid disorders ( Sniezek & Francis, 2003 ), without continuous use of anti-inflammatory drugs (at least 6-8 weeks before the start of the study) were included in our study. Patients with ovarian hyperstimulation syndrome (OHSS) and poor response to ovarian stimulation were considered as exclusion criteria.…”

Section: Methodsmentioning

confidence: 99%

Abdominal Obesity May Play a Significant Role in Exacerbation of Inflammation in Polycystic Ovary Syndrome Patients

Shirvanizadeh,

Eidi,

Hafezi

et al. 2023

JBRA

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Objective Polycystic ovary syndrome (PCOS) is an endocrine disorder that seems to be pro-inflammatory at many levels, abdominal obesity (AO) is a prevalent pro-inflammatory phenotype in PCOS patients, and it seems to contribute to the initiation or worsening of inflammation in PCOS patients. In this study, we investigated the role of the AO phenotype in the occurrence of other obesity indicators (neck and arm) and augmentation of inflammation in the follicular fluid (FF) of PCOS patients. Methods 40 patients under the age of 35 were divided into four groups: PCOS with AO, PCOS without AO, non-PCOS with AO, and non-PCOS without AO. The FF samples were collected from each patient. Clinical and anthropometric characteristics of the participants, as well as tumor necrosis factor-α (TNF-α) concentration in the FF samples, were quantitatively assessed using enzyme-linked immunosorbent assays. The number of retrieved cumulus-oocyte complexes (COC) and their quality were scored. Results The PCOS + AO + group had significantly increased neck circumference, compared to the other groups ( p <0.001). The concentration of TNF-α was significantly higher in the PCOS+AO+ group than in the other groups ( p <0.001). There were no significant differences in the number of retrieved COC per patient and the quality of oocytes between the groups ( p >0.05). Conclusions Given the significant role of inflammation in the development of PCOS, managing AO in PCOS patients may aid in reducing inflammation and could potentially help in the design of customized treatment approaches.

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Section: Methodsmentioning

confidence: 99%