Inflammatory responses induced in mice by lectin from Talisia esculenta seeds

Freire, Maria G. M.; DeSouza, Ivani A.; Silva, A.C.M; Macedo, Maria Lígia Rodrigues; Lima, Maria Érica de Oliveira; Tamashiro, Wirla Maria da Silva Cunha; Antunes, Edson; Marangoni, Sérgio

doi:10.1016/s0041-0101(03)00142-9

Cited by 24 publications

(22 citation statements)

References 18 publications

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“…T. esculenta seeds contain talisin, a reserve protein that act as a storage protein, presenting lectin-like activities i.e. caracterized by a weakly hemagglutination inhibition of human and animal erythrocytes in high concentrations (starting from 500μg mL −1 ) (Freire et al 2003). In addition, talisin also displays protease-inhibitor properties, as bovine trypsin, and induces neutrophil and mononuclear cell inflammatory response by a mechanism related to specific protein-carbohydrate interactions (Freire et al 2003, Macedo et al 2011.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous poisoning by Talisia esculenta in cattle

et al. 2019

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Talisia esculenta, commonly known as pitombeira, is a tree which fruits are widely consumed by human beings in northeastern Brazil. The aim of this work is to describe the epidemiological, clinical and pathological aspects of two outbreaks of spontaneous poisoning by T. esculenta in cattle in the dry region of Pernambuco, northeastern Brazil. The cases occurred in the municipalities of São Bento do Una and Belo Jardim. From a total of 25 adult cattle, eight become sick after ingest T. esculenta leaves and fruits. Four cattle died until 72 hours after the first clinical signs; which consisted in ataxia, reluctance to walk, tottering, head tremors muscle spasms in the limbs, rigidity of the pelvic limbs with wide base stance position, ruminal atony and, when stressed, presented falls and remained in abnormal positions. Two cattle were necropsied; the only significant finding was the presence of partially digested leaves, barks and seeds of T. esculenta in ruminal contents. Microscopically no lesions were observed. There is no specific therapy for poisoning by T. esculenta leaves. Prophylaxis consists in preventing cattle from gaining access to pasture areas containing the plant.

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Section: Discussionmentioning

confidence: 99%

“…The poisoning was also reproduced experimentally in sheep (Riet-Correa et al 2014). The main toxin of T. esculenta seeds and leaves is still unknown, however, seeds and leaves contain talisin, a lectin that has hemagglutinating erythrocyte activity (Freire et al 2003).…”

Section: Introductionmentioning

confidence: 96%

Spontaneous poisoning by Talisia esculenta in cattle

et al. 2019

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“…Freire et al also have found that mannose, but not glucose or galactose, inhibits neutrophil migration into the peritoneal cavity or air-pouch, and inhibits paw oedema. This may be related to their specifi c sugar-binding properties [31]. Chen et al suggests strict control of blood sugar is warranted in ALI, since infusing insulin to control plasma glucose is effective in reducing the LPS-induced ALI [32].…”

Section: Discussionmentioning

confidence: 99%

Mannose prevents lipopolysaccharide-induced acute lung injury in rats

Xie

Shen

et al. 2008

Inflamm. res.

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“…The rodent air pouch model of acute inflammation is probably the best, simple, not time-consuming, and cheapest model for monitoring leukocyte influx, including PMNs. This model has been used for investigating the inflammatory activity of a large number of compounds, including cytokines [28,43,80], plant extracts and lectins [81][82][83], different drugs [84][85][86], etc.…”

Section: Evaluating Pmn Infiltration In Vivomentioning

confidence: 99%

Focussing on Neutrophils for Evaluating In vitro and In vivo Inflammatory Activities of Nanoparticles

Girard¹

2015

Nanomaterials - Toxicity and Risk Assessment

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Abstract" tremendous interest to use nanomaterials for medical diagnosis and therapeutic purposes has increased in the past few years. "lthough a lot of investigations focus on the use of nanoparticles NPs for drug delivery in cancer therapies, there are several studies investigating the potential use of NPs as carriers to detect allergies or to alleviate inflammatory symptoms. However, although this represents a very interesting interest and a potential avenue to use nanodrug systems, there are some potential toxic risks. For example, cytotoxicity, oxidative stress, genotoxicity, and inflammation have been reported both in in vitro and in vivo models for testing NPs.In addition to medicine, a variety of other sectors, including electronics, cosmetics, aerospace, textile industries, and even in food, used NPs. Consequently, the probability of human exposure to NPs has risen, leading to the possibility that NPs may reach the blood circulation and interact with immune blood cells. Therefore, it is crucial to evaluate the risk that NPs represent to human health. In different studies using in vivo models of inflammation, especially those investigating airway NP exposure, an increased number of leukocytes, mainly neutrophils, in the lungs and bronchoalveolar lavages have been reported. In fact, neutrophil counts are used as biomarkers of inflammation. Despite this and knowing that neutrophils are key player cells in inflammation, it is intriguing that few nanotoxicology studies have focused on how NPs can directly alter the biology of these cells. However, an increasing amount of studies, including some from my laboratory, demonstrate that NPs can activate human neutrophils by different manners in vitro and can attract them or not in vivo. The focus of this review will be to cover this new area of research. Keywords: Inflammation, neutrophils, nanotoxicology© 2015 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. . IntroductionThe use of nanoparticles NPs has increased in the past few years in various fields, including textile, sport, defense, aerospace, electronics, biology, medicine, etc. There is also a growing interest to use NPs in different applications, including diagnostic technology, bioimaging, and drug/gene delivery. Therefore, voluntary or nonvoluntary human exposure to NPs and nanomaterials is unavoidable and will certainly expand in the near future. This has led to a growing interest in nanotoxicology, the study of toxicity of nanomaterials. Especially, a number of studies reported the effects of NPs on pulmonary inflammation by investigating in vitro activation of pulmonary cells with NPs and in vivo in a variety of models in which neutrophils appear to be the predominant leukocyte cell type in the lungs and in bronchoalveolar lavages following inhalation or intratra...

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Inflammatory responses induced in mice by lectin from Talisia esculenta seeds

Cited by 24 publications

References 18 publications

Spontaneous poisoning by Talisia esculenta in cattle

Spontaneous poisoning by Talisia esculenta in cattle

Mannose prevents lipopolysaccharide-induced acute lung injury in rats

Focussing on Neutrophils for Evaluating In vitro and In vivo Inflammatory Activities of Nanoparticles

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