Inflammatory response of uric acid produced by <i>Porphyromonas gingivalis</i> gingipains

Jun, Hye‐Kyung; An, Sun‐Jin; Kim, Ho; Choi, Bong‐Kyu

doi:10.1111/omi.12309

Cited by 7 publications

(10 citation statements)

References 42 publications

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“…Serum uric acid can activate the nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome to produce IL‐1β in human monocytes (Alberts et al, 2019). In addition, Porphyromonas gingivalis gingipain‐induced uric acid production can mediate inflammation in periodontal tissue cells (Jun et al, 2020). Many prior studies have shown consistently that serum uric acid levels were positively correlated with the severity of periodontitis (Banu et al, 2015; Cao et al, 2016; Babaei et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Associations between metabolic biomarkers and localized stage II/III periodontitis in young adults: The CHIEF Oral Health study

Tsai

Cheng

et al. 2021

J Clinic Periodontology

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Aim: To investigate the associations between metabolic risk factors and periodontitis in young adults. Materials and methods: The study included 1123 participants, aged 19-40 years, in Taiwan. Metabolic syndrome components were defined by the International Diabetes Federation criteria. Localized periodontitis was graded to healthy (n = 828) and stage II/III (n = 295) according to the 2017 criteria of the World Workshop. Multiple logistic regression analysis with adjustment for sex, age, betel nut consumption, and smoking were used to determine the associations. Results: Greater waist circumference, serum triglycerides, and serum uric acid were associated with higher localized stage II/III periodontitis risk [odds ratio (OR) and 95% confidence interval (

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Section: Discussionmentioning

confidence: 99%

Associations between metabolic biomarkers and localized stage II/III periodontitis in young adults: The CHIEF Oral Health study

Tsai

Cheng

et al. 2021

J Clinic Periodontology

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“…Porphyromonas gingivalis is a major periodontopathogen, and its gingipain proteases play a critical role in the pathogenesis of periodontitis. gingipain-induced UA can mediate inflammation in periodontal tissue cells [ 36 ]. UA is also associated with the risk of incident CHD [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Risk of coronary heart disease in patients with periodontitis among the middled-aged and elderly in China: a cohort study

Gao

Liu

et al. 2021

BMC Oral Health

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Background Convincing evidence of the periodontitis as a risk factor for coronary heart disease (CHD) is lacking due to shared risk factors, and no cohort study has investigated the association between CHD and periodontitis in Chinese populations. Methods This study used a prospective cohort study design. The analysis included 4591 participants aged 40 years and older (3146 men and 1445 women). The association between CHD and periodontitis was estimated using relative risk (RR) calculated using modified Poisson regression. Multiple mediation analysis was used to differentiate the relative effects (RE) from different risk factors on the effect of periodontitis on CHD. Results In the analysis using the imputed dataset and fully adjusted model, participants with periodontitis at baseline had 37% increased risk of CHD overall compared to those without periodontitis at baseline (RR 1.37; 95% CI 0.96–1.95). Most of the association can be explained by age, sex, history of diabetes, history of hypertension, uric acid and education (RE 0.76; 95% CI 0.41–1.02). Conclusion Periodontitis was weakly associated with an increased risk of CHD among the middled-aged and elderly in China. Further studies are required to identify more mediators and elucidate the mechanisms of how periodontitis increases the risk of CHD.

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“…Uric acid sodium salt induces cell death, caspase-1 activation, and the expression of pro-inflammatory cytokines, including IL-1α, IL-6, and IL-8, in a human keratinocyte (HOK-16B) cell line. These results suggest that gingipain-induced uric acid possibly mediates inflammation in cells of periodontal tissues [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Porphyromonas gingivalis W83 Membrane Components Induce Distinct Profiles of Metabolic Genes in Oral Squamous Carcinoma Cells

Groeger

Herrmann

Chakraborty

et al. 2022

IJMS

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Periodontitis, a chronic inflammatory disease is caused by a bacterial biofilm, affecting all periodontal tissues and structures. This chronic disease seems to be associated with cancer since, in general, inflammation intensifies the risk for carcinoma development and progression. Interactions between periodontal pathogens and the host immune response induce the onset of periodontitis and are responsible for its progression, among them Porphyromonas gingivalis (P. gingivalis), a Gram-negative anaerobic rod, capable of expressing a variety of virulence factors that is considered a keystone pathogen in periodontal biofilms. The aim of this study was to investigate the genome-wide impact of P. gingivalis W83 membranes on RNA expression of oral squamous carcinoma cells by transcriptome analysis. Human squamous cell carcinoma cells (SCC-25) were infected for 4 and 24 h with extracts from P. gingivalis W83 membrane, harvested, and RNA was extracted. RNA sequencing was performed, and differential gene expression and enrichment were analyzed using GO, KEGG, and REACTOME. The results of transcriptome analysis were validated using quantitative real-time PCR with selected genes. Differential gene expression analysis resulted in the upregulation of 15 genes and downregulation of 1 gene after 4 h. After 24 h, 61 genes were upregulated and 278 downregulated. GO, KEGG, and REACTONE enrichment analysis revealed a strong metabolic transcriptomic response signature, demonstrating altered gene expressions after 4 h and 24 h that mainly belong to cell metabolic pathways and replication. Real-time PCR of selected genes belonging to immune response, signaling, and metabolism revealed upregulated expression of CCL20, CXCL8, NFkBIA, TNFAIP3, TRAF5, CYP1A1, and NOD2. This work sheds light on the RNA transcriptome of human oral squamous carcinoma cells following stimulation with P. gingivalis membranes and identifies a strong metabolic gene expression response to this periodontal pathogen. The data provide a base for future studies of molecular and cellular interactions between P. gingivalis and oral epithelium to elucidate the basic mechanisms of periodontitis and the development of cancer.

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Inflammatory response of uric acid produced by Porphyromonas gingivalis gingipains

Cited by 7 publications

References 42 publications

Associations between metabolic biomarkers and localized stage II/III periodontitis in young adults: The CHIEF Oral Health study

Associations between metabolic biomarkers and localized stage II/III periodontitis in young adults: The CHIEF Oral Health study

Risk of coronary heart disease in patients with periodontitis among the middled-aged and elderly in China: a cohort study

Porphyromonas gingivalis W83 Membrane Components Induce Distinct Profiles of Metabolic Genes in Oral Squamous Carcinoma Cells

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