“…Even within ‘self-perceived healthy’ adults, existing severe periodontitis could well indicate the possible presence of multiple inflammatory comorbidities [ 16 ]. Moreover, periodontopathogens such as Porphyromonas gingivalis ( P. gingivalis ) is associated with cardiovascular disease [ 17 , 18 , 19 ], cancer [ 20 , 21 , 22 ], insulin resistance [ 23 , 24 ], Alzheimer’s disease [ 25 , 26 ], and adverse pregnancy outcomes [ 27 , 28 ]. Furthermore, clinical periodontal treatment is able to improve the anemic status [ 29 ], modulates endotoxemia and stool microbial dysbiosis [ 30 ], could reduce the risks of perinatal mortality and preterm birth [ 31 ], and is beneficial for the effective management of type 2 diabetes [ 32 , 33 , 34 ].…”