Inflammatory response in chronic degenerative endometritis mares treated with platelet-rich plasma

Reghini, Maria Fernanda Svizzero; Neto, C. Ramires; Segabinazzi, Lorenzo G.T.M.; Chaves, Maria Manoela B. Castro; Dell’Aqua, Camila de Paula Freitas; Caldas-Bussiere, M.C.; Dell’Aqua, J.A.; Papa, Federico; Alvarenga, Marco Antônio

doi:10.1016/j.theriogenology.2016.01.029

Cited by 55 publications

(69 citation statements)

References 51 publications

(68 reference statements)

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“…Platelets carry more than 800 proteins, namely cytokines, hormones and chemoattractants of stem cells, macrophages and neutrophils, responsible for various post-translational modifications of nearly 1,500 bioactive factors (19). Platelets also carry numerous growth factors of great significance due to their ability to repair tissue as well as their mitogenic, chemotactic, neovascular and anti-inflammatory effects (20). These factors include: vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), keratinocyte growth factor (KGF), connective tissue growth factor (CTGF), basic fibroblast growth factor (bFGF), insulin-like growth factor 1 (IGF-I), epidermal growth factor (EGF) and 2 (IGF-II) and hepatocyte growth factor (HGF), which are released following alpha granule activation by native or exogenous molecules, including thrombin, collagen, magnesium and calcium chloride.…”

Section: Abstract Background/aim: Patients Diagnosed Withmentioning

confidence: 99%

Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis

Sfakianoudis

Simopoulou

Nitsos

et al. 2019

In Vivo

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Section: Abstract Background/aim: Patients Diagnosed Withmentioning

confidence: 99%

Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis

Sfakianoudis

Simopoulou

Nitsos

et al. 2019

In Vivo

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“…Each mare served as its own control and the treatment was performed with intrauterine PRP infusion four hrs after artificial insemination. They concluded that PRP was effective in modulating the exacerbated uterine inflammatory response to semen in mares with chronic degenerative endometritis [27,38] .…”

Section: Results Of the Study In The Context Of Other Observationsmentioning

confidence: 99%

PRP in recurrent implantation failure, hope or hype? A Prospective randomized controlled study

Rageh

Barakat

Ahmed

et al. 2020

Evidence Based Women's Health Journal

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Introduction:The endometrial function and endometrial receptivity have been accepted to be major limiting factors in the establishment of pregnancy. In spite of improved almost all aspects of IVF: ovarian stimulation, embryo culture and transfer, the pregnancy rates still not satisfactory. The bottleneck is the process of implantation. Recurrent implantation failure (RIF) is one of the nightmares in reproductive medicine and despite several strategies that have been described for management; there is no universal agreement yet. Recently, intrauterine infusion of platelet-rich plasma (PRP) is described to promote endometrial growth and receptivity, PRP has been investigated as a therapeutic approach for several medical disorders in dermatology and rheumatology, but its use in IVF is still limited. Aim: To evaluate the effectiveness of intrauterine perfusion of autologous platelet-rich plasma in improvement of pregnancy rate in RIF patients. Design: Prospective randomized controlled study. Patients and Methods: After ethical committee approval was obtained, 150 infertile women with history of RIF gave their consent to be included in this study, with age below 40 yrs, body mass index (BMI) below 30 kg/m2. They were divided into 2 comparable groups ; all participants underwent antagonist protocol. In the study group, intrauterine infusion of (PRP) was performed 48 hrs before blastocyst transfer, pregnancy tests were done 12 days after ET. Results: Out of 75 participants in each group, 32 got pregnant (43%) in the study group, compared to 11 pregnant participants (15%) in control group. Conclusion: According to our study, PRP significantly improved the pregnancy rate and may be a new hope in RIF patients.

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“…Farimani et al have stated that local PRP administration prior to embryo transfer in recurrent implantation failures may improve the success of implantation 38 . PRP can also suppress the inflammatory process in the development of endometriosis 39 .…”

Section: Discussionmentioning

confidence: 99%

The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

Anğın

Gün

Sakin

et al. 2019

Preprint

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29Our aim was to investigate the effect of platelet-rich plasma (PRP) derivatives, which 30 can be produced from the patient's own blood and have minimal side effects, on 31 endometriosis. To the best of our knowledge, this is the first study in the literature that studies 32 the relationship between PRP and endometriosis. Endometriosis foci were created in the first 33 operation. In the second operation (30 th day) groups were formed. Group 1 (n= 8) was 34 administered saline, group 2 (n= 7) leukocyte-and platelet-rich plasma (L-PRP), and group 3 35 (n= 8) pure platelet-rich plasma (P-PRP). Group 4 (n= 10) was used to obtain PRP. In the last 36 operation (60 th day), the endometriotic foci were measured, and then excised. There was no 37 statistically significant difference between the pre and post volumes of the endometriotic foci, 38 between their volume differences and volume difference rates (p > .05). However, it was 39 observed that existing implant volumes in all groups decreased statistically significantly 40 within their own groups by the end of the experiment compared to the previous volumes (p < 41 .05). When the implants were assessed through histopathological scoring in terms of edema, 42 vascular congestion, inflammatory cell infiltration, hemorrhage, epithelial line, and 43 hemosiderin accumulation and immunohistochemical staining in terms of VEGF, there was 44 no significant difference in the comparison between the groups. Although L-PRP and P-PRP 45 generated more reduction in the endometriosis foci, they did not create any statistical 46 differences. 48Endometriosis, which is described as the presence of endometrial gland and stroma 49 outside the uterine cavity, is an important women's health problem seen in 6-10% of women 50 that causes degradation in the quality of life with clinical effects, such as infertility, 3 51 dysmenorrhea, dyspareunia and chronic pelvic pain 1-4 . Its pathophysiology has not yet been 52 fully resolved, and an effective treatment for it has not yet been found 5,6 . 53

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Inflammatory response in chronic degenerative endometritis mares treated with platelet-rich plasma

Cited by 55 publications

References 51 publications

Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis

Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis

PRP in recurrent implantation failure, hope or hype? A Prospective randomized controlled study

The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

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