Inflammatory Pseudo-tumor of the Liver Accompanied by Eosinophilia

Abstract

A 28-year-old woman was referred to our hospital for liver dysfunction and neck pain. Blood tests revealed elevated liver enzymes and eosinophilia. Ultrasonography, computed tomography, and magnetic resonance imaging showed a mass lesion near the hepatic hilus. The tumor was considered to be an inflammatory pseudo-tumor or malignancy. A liver-mass biopsy was performed and led to a diagnosis of inflammatory pseudo-tumor. In the present case, a markedly elevated eosinophil count was a characteristic clinical feature, and the patient underwent steroid therapy. Treatment resulted in a reduced eosinophil count, improved neck symptoms, and disappearance of the inflammatory pseudo-tumor.

Multiple Inflammatory Pseudotumors of the Liver Demonstrating Spontaneous Regression: A Case Report

“…IPT is a rare inflammation-related benign tumor with histopathological findings of the proliferation of myofibroblastic cells and the infiltration of inflammatory cells [11]. IPT has been most frequently reported as a lung tumor and rarely develops in the liver [1][2][3]. The etiology and pathogenesis of IPT are uncertain, although various factors, such as autoimmune disorders, infections, chronic biliary inflammation, and traumatic injury, have been suggested to be associated with its development [6,[12][13][14].…”

“…Life 2022, 12, x FOR PEER REVIEW 2 of 10 features [1][2][3], IPT is sometimes difficult to discriminate from a malignant tumor. IPTs are most frequently reported as lung tumors, with liver IPTs being uncommon.…”

“…Inflammatory pseudotumor (IPT) is a rare benign tumor whose histological findings are characterized by the proliferation of myofibroblastic cells with the infiltration of inflammatory cells, including plasma cells, lymphocytes and macrophages [1][2][3]. Most IPT cases are detected as solitary tumors, and due to a lack of specific clinical and imaging features [1][2][3], IPT is sometimes difficult to discriminate from a malignant tumor. IPTs are Life 2022, 12, 124 2 of 8 most frequently reported as lung tumors, with liver IPTs being uncommon.…”