Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (<scp>PLCO</scp>) Cancer Screening Trial

Zheng, Jiali; Merchant, Anwar T.; Wirth, Michael D.; Zhang, Jiajia; Antwi, Samuel O.; Shoaibi, Azza; Shivappa, Nitin; Hébert, James R.; Steck, Susan E.

doi:10.1002/ijc.31271

Cited by 30 publications

(30 citation statements)

References 47 publications

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“…6). Our findings agreed with previously conducted analyses using the prospective PLCO study, which reported an overall null association among 101,449 participants with baseline demographics similar to this study (7). Possible selection bias, frequent use of proxy responses, and other sources of information bias in pancreatic cancer case-control studies that may contribute to differential misclassification could help to explain differences in results from cohort studies.…”

Section: Discussionsupporting

confidence: 91%

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Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results from the NIH-AARP Diet and Health Study

Zheng

Wirth

Merchant

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Chronic inflammation is implicated in pancreatic cancer, and can be modulated by diet and other lifestyle factors. We examined the association between Dietary Inflammatory Index (DII) scores and pancreatic cancer risk in the NIH-AARP Diet and Health Study, and examined effect modification by inflammation-related lifestyle factors, including body mass index, cigarette smoking, diabetes, alcohol drinking, and use of non-steroidal anti-inflammatory drugs. Methods: Energy-adjusted DII scores (E-DII) were computed on the basis of food frequency questionnaire responses for foods and dietary supplements. Cox proportional hazards models were fitted and effect modification was examined by adding a cross-product of each effect modifier with E-DII quintile in the multivariable-adjusted model. Results: There were 2,824 primary incident pancreatic cancers diagnosed during a median of 13.4 years follow-up, and there was no association between E-DII scores and pancreatic cancer risk among either men [HR Q5vsQ1 , 1.00; 95% confidence interval (CI), 0.86-1.16] or women (HR Q5vsQ1 , 1.00; 95% CI, 0.82-1.21) in the multivariable-adjusted model, and no association was detected by any cancer stage. The E-DII and pancreatic cancer association was not modified by any of the inflammation-related lifestyle factors examined. Conclusions: Results from this large prospective study did not support an association between inflammatory potential of diet and pancreatic cancer, or effect modification by other inflammation-related lifestyle factors. Impact: Inflammatory potential of diet may not be related to pancreatic cancer risk. Future cohort studies with more frequent dietary measures could be useful in determining the appropriate timing of dietary intake in relation to pancreatic cancer etiology.

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Section: Discussionsupporting

confidence: 91%

“…The PLCO cohort suggested reverse causality for E-DII and pancreatic cancer association, where an inverse association between pro-inflammatory diets and pancreatic cancer risk was observed in follow up of <4 years (7). The current study did not support this phenomenon, even in the lag time analysis.…”

Section: Discussioncontrasting

confidence: 85%

Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results from the NIH-AARP Diet and Health Study

Zheng

Wirth

Merchant

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Dietary assessment was similar to our previous study 48 . Diet was assessed by a self-reported food frequency questionnaire (FFQ), the DHQ version 1.0 (National Cancer Institute, 2007) introduced in 1998 to the control and intervention arms within a median of three years after randomization in this trial 49,50 .…”

Section: Dietary Assessmentsupporting

confidence: 64%

Long-term anti-inflammatory diet in relation to improved breast cancer prognosis: a prospective cohort study

Wang

Sun

et al. 2020

npj Breast Cancer

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Inflammation-modulating nutrients and inflammatory markers are established cancer risk factors, however, evidence regarding the association between post-diagnosis diet-associated inflammation and breast cancer survival is relatively sparse. We aimed to examine the association between post-diagnosis dietary inflammatory index (DII®) and risks of all-cause and breast cancer-specific mortality. A total of 1064 female breast cancer survivors in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening (PLCO) Trial prospective cohort, were included in this analysis if they had completed the diet history questionnaire (DHQ). Energy-adjusted DII (E-DII TM) scores were calculated based on food and supplement intake. Cox regression and competing risk models were used to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by E-DII tertile (T) for all-cause and breast cancer-specific mortality. With median follow-up of 14.6 years, there were 296 (27.8%) deaths from all causes and 100 (9.4%) breast cancer-specific death. The E-DII was associated with all-cause mortality (HR T3 vs T1, 1.34; 95% CI, 1.01-1.81; P trend , 0.049, Table 2) and breast cancer mortality (HR T3 vs T1, 1.47; 95% CI, 0.89-2.43; P trend , 0.13; multivariable-adjusted HR for 1-unit increment: 1.10; 95% CI: 1.00-1.22). Non-linear positive dose-response associations with mortality from all causes were identified for E-DII scores (P non-linearity < 0.05). The post-diagnosis E-DII was statistically significantly associated with mortality risk among breast cancer survivors. Long-term anti-inflammatory diet might be a means of improving survival of breast cancer survivors.

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“…In a prospective cohort, in order to evaluate the E-DII and the risk for colorectal cancer in 190,963 individuals of both sexes and between 45 and 75 years old, Harmon et al [19] found an E-DII of -6.64 to 4.95. In another prospective cohort, Zheng et al [20] verified the survival rate of post-colorectal cancer women between 50 and 79 years old and the relationship with the E-DII. There was a variation of -6.8 to 3.25.…”

Section: Discussionmentioning

confidence: 94%

Factors associated with the inflammatory potential of the Brazilian population’s diet

et al. 2020

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Objectives: To assess the inflammatory potential of the Brazilian population’s diet and its association with demographic, socioeconomic, and anthropometric characteristics. Methods: Cross-sectional study performed with 34,003 individuals aged 10 and older, evaluated by the National Diet and Nutrition Survey (INA) from the Consumer Expenditure Survey (POF 2008-2009). The Energy-adjusted Dietary Inflammatory Index (E-DIITM) was determined using 34 dietary parameters calculated through non-consecutive 2-day dietary records. Positive scores indicate a pro-inflammatory diet, while negative scores indicate an anti-inflammatory diet. A bivariate and multivariate linear regression analysis based on a hierarchical theoretical model was performed to verify the factors associated with the E-DII. Results: The mean of the E-DII was 1.04, with a range of -4.77 to +5.98. The highest values of the pro-inflammatory E-DII were found among adolescents (1.42; p-value<0.001) and individuals with higher income (1.10; p-value<0.001) and level of education (1.18; p-value<0.001). In the final model, the E-DII was associated with higher income quartiles, was higher in the Northeast and South regions, in white people, individuals with ≥9 years of education and adults and adolescents age group. Conclusion: The Brazilian population consumes a diet with high inflammatory potential, especially adolescents, white people and those with higher income and level of education. Thus, the index presented uneven distribution among the population, emphasizing groups with higher dietary inflammatory potential. The socioeconomic risk profile of a diet with higher inflammatory potential in medium-income countries is different from what is observed in high-income nations.

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Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial

Cited by 30 publications

References 47 publications

Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results from the NIH-AARP Diet and Health Study

Inflammatory Potential of Diet, Inflammation-Related Lifestyle Factors, and Risk of Pancreatic Cancer: Results from the NIH-AARP Diet and Health Study

Long-term anti-inflammatory diet in relation to improved breast cancer prognosis: a prospective cohort study

Factors associated with the inflammatory potential of the Brazilian population’s diet

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