Inflammatory Myofibroblastic Tumor of the Kidney in a Child: Report of a Case

Boo, Yoon Jung; Kim, Jin; Kim, Jong Han; Kim, Chong Suk; Suh, Soon Yong

doi:10.1007/s00595-006-3225-6

Cited by 15 publications

(18 citation statements)

References 35 publications

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“…Our search for literature revealed only 5 cases of renal IMT in children. 3,4,5,8,9 Thus, to our knowledge, the present case represents the sixth case of renal IMT in a child and the first reported case accompanied by multiple lung nodules.…”

Section: Discussionmentioning

confidence: 71%

“…2,3 It has also been termed as inflammatory myofibroblastic proliferation, inflammatory pseudotumor, plasma cell granuloma, xanthomatous pseudotumor, myofibroblastoma, and pseudosarcamatous fibromyxoid tumor. 2,3 Although the lung is the most commonly affected site, IMT can be encountered almost everywhere in the body including head and neck, gastrointestinal, hepatobiliary, genitourinary system, and soft tissues of the trunk and extremities. 1,[10][11][12] IMT is characterized histologically by the presence of acute and chronic inflammatory cells including lymphocytes, plasma cells, and myofibroblastic spindle cells with a variable fibrous response.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Renal occurrence of IMT is extremely rare, 1-7 with only 5 previously reported cases in children up to date. [3][4][5]8,9 In the pediatric age group, it is usually difficult to differentiate a renal IMT from a malignancy such as Wilms tumor. We report a case of a 3-year-old boy with a right renal mass accompanied by bilateral lung lesions mimicking Wilms tumor and its lung metastases on preoperative diagnostic images, which were pathologically revealed to be IMT lesions.…”

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confidence: 99%

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Inflammatory Myofibroblastic Tumor of the Kidney and Bilateral Lung Nodules in a Child Mimicking Wilms Tumor With Lung Metastases

Dogan¹,

Doğanay²,

Koc³

et al. 2015

Journal of Pediatric Hematology/Oncology

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Inflammatory Myofibroblastic Tumor of the Kidney and Bilateral Lung Nodules in a Child Mimicking Wilms Tumor With Lung Metastases

Dogan¹,

Doğanay²,

Koc³

et al. 2015

Journal of Pediatric Hematology/Oncology

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“…Most renal IMT cases have undergone surgical resection, and nephrectomy is usually performed due to the mimicry of malignancy on imaging findings, such as renal carcinoma or Wilms tumor. 5 , 15 , 21 , 22 In some cases that were not treated by resection, corticosteroid therapy was somewhat beneficial. 9 , 10 In our case, because the preoperative imaging was similar to cystic renal cell carcinoma, surgical resection was implemented, and no recurrence was observed during follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the prognosis of IMT in the kidney is good. 2 , 5 Therefore, clinicians need to be familiar with the imaging findings so that they can develop an appropriate treatment strategy before surgery. We report 1 case of renal IMT that was found during a health examination, and its imaging findings were similar to cystic renal cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

A Renal Inflammatory Myofibroblastic Tumor Similar to Cystic Renal Cell Carcinoma

Liang

2015

Medicine

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We describe and analyze the clinical course and imaging findings of a case of a renal inflammatory myofibroblastic tumor (IMT) that is similar to cystic renal cell carcinoma.“Solitary cysts” on the left kidney were found during a health examination of a 60-year-old female. The patient also had hypertension. She had undergone surgeries twice for limb trauma fracture and had no definite record of hepatitis. There was no tenderness with percussion of the kidney area or edema in the lower extremity. The renal function results, including serum creatinine, blood urea nitrogen, and blood urea, were within the normal range. No gross hematuria or microscopic hematuria was found. An 8.7 cm × 9.2 cm mixed echogenic mass at the upper pole of the left kidney was observed with ultrasound, the majority of which was an anechoic mass that was slightly protruding from the renal capsule and had well-circumscribed borders. After a bolus injection of an ultrasound contrast agent, the mass had rapid enhancement with fast fading. An approximately 9.4 cm × 10.1 cm round-like cyst lesion at the upper pole of the left kidney was revealed by computed tomography (CT) examination of the abdomen; it had edge finishing with well-circumscribed borders. The upper inner wall of the lesion was thick with crescentic soft tissue. The solid content had gradual enhancement on enhanced CT scans. A kidney tumor was considered based on the CT findings.Based on the preoperative examination, the left renal cystic masses were resected. Intraoperative frozen sections were used to further clarify the nature of the lesion, and no significant malignant cells were observed; therefore, the kidney was not removed. The pathological diagnosis was renal IMT. After surgery, the patient recovered and did not have recurrence or metastasis over the course of long-term follow-up.CT images of our patient with renal cystic disease are categorized as Fuhrman grade IV and typically indicate the presence of malignant lesions. However, gradual enhancement of the solid content in our case is different from typical cystic renal cell carcinoma. The nature of the lesion was further identified using intraoperative frozen sections, which helped avoid unnecessary nephrectomy.

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Shedding light on inflammatory pseudotumor in children: spotlight on inflammatory myofibroblastic tumor

et al. 2015

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Inflammatory pseudotumor is a generic term used to designate a heterogeneous group of inflammatory mass-forming lesions histologically characterized by myofibroblastic proliferation with chronic inflammatory infiltrate. Inflammatory pseudotumor is multifactorial in etiology and generally benign, but it is often mistaken for malignancy given its aggressive appearance. It can occur throughout the body and is seen in all age groups. Inflammatory pseudotumor has been described in the literature by many organ-specific names, resulting in confusion. Recently within this generic category of inflammatory pseudotumor, inflammatory myofibroblastic tumor has emerged as a distinct entity and is now recognized as a fibroblastic/myofibroblastic neoplasm with intermediate biological potential and occurring mostly in children. We present interesting pediatric cases of inflammatory myofibroblastic tumors given this entity's tendency to occur in children. Familiarity and knowledge of the imaging features of inflammatory pseudotumor can help in making an accurate diagnosis, thereby avoiding unnecessary radical surgery.

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Inflammatory Myofibroblastic Tumor of the Kidney in a Child: Report of a Case

Cited by 15 publications

References 35 publications

Inflammatory Myofibroblastic Tumor of the Kidney and Bilateral Lung Nodules in a Child Mimicking Wilms Tumor With Lung Metastases

Inflammatory Myofibroblastic Tumor of the Kidney and Bilateral Lung Nodules in a Child Mimicking Wilms Tumor With Lung Metastases

A Renal Inflammatory Myofibroblastic Tumor Similar to Cystic Renal Cell Carcinoma

Shedding light on inflammatory pseudotumor in children: spotlight on inflammatory myofibroblastic tumor

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