Inflammatory Myofibroblastic Tumor of the Kidney and Bilateral Lung Nodules in a Child Mimicking Wilms Tumor With Lung Metastases

Dogan, Mehmet Sait; Doğanay, Selim; Koc, Gonca; Görkem, Süreyya Burcu; Ünal, Ekrem; Öztürk, Figen; Çoşkun, Abdulhakim

doi:10.1097/mph.0000000000000353

Cited by 11 publications

(12 citation statements)

References 13 publications

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“…To date, only IMTs of the kidney and bilateral lung nodules in a child were reported. [ 18 ] We do not know whether the abdominal wall of IMT is metastases or synchronized lesions. We consider that the occurrence of the tumors in 2 locations may be 1 tumor is metastases from another or a simple incidental coexistence.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumors in the kidney and abdominal wall mimicking malignancy

Wang

Xue³

et al. 2018

Medicine

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Rationale:Inflammatory myofibroblastic tumor (IMT) is uncommon, coexistence of IMTs in the kidney and abdominal wall are more uncommon.Patient concerns and diagnosis:We report a 74-year-old female who presented with 6 months history of left flank pain and approximately 5 kg weight loss that were diagnosed as renal cell carcinoma and locally metastatic abdominal wall tumor.Interventions and outcomes:A left radical nephrectomy and excision of the abdominal wall tumor were done. The pathologic result was IMTs. After follow-up for 66 months, the patient showed no signs of tumor recurrence.Lessons:Coexistence of IMTs in the kidney and abdominal wall is extremely rare and is often diagnosed as malignancy. Therefore, IMTs should be considered in the diagnosis of the patient with both kidney and abdominal wall tumors.

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Section: Discussionmentioning

confidence: 99%

Inflammatory myofibroblastic tumors in the kidney and abdominal wall mimicking malignancy

Wang

Xue³

et al. 2018

Medicine

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“…To further study the characteristics of this type of IMT, we reviewed case reports published in MEDLINE and PubMed databases between 1972 and 2019, including 48 cases occurring in the renal parenchyma (37 cases) and renal pelvis (11 cases) (Table 1). Although the patients ranged in age from 3 to 75 years[6,7], those aged over 40 years accounted for 73% (35/48) of cases. Only five patients were younger than 14 years old.…”

Section: Discussionmentioning

confidence: 99%

Kidney inflammatory myofibroblastic tumor masquerading as metastatic malignancy: A case report and literature review

Zhang¹,

Guo²,

Liang³

et al. 2019

WJCC

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BACKGROUNDInflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that is characterized by spindle cells differentiated from muscle fibroblasts and infiltration of various types of inflammatory cells. IMT can occur at any age and at any anatomic site. The most common location of IMT is the bladder in the genitourinary tract. Only scarce cases of kidney IMT have been reported in the literature.CASE SUMMARYA 77-year-old woman, with a history of bilateral renal calculus for 15 years, was admitted to the Department of Urology of our hospital complaining of recurrent painless gross hematuria for one month. The treatment with cephalosporin was ineffective. Computed tomography imaging showed a mixed density and slightly heterogeneously enhanced lesion in the middle pole of the left kidney and ipsilateral adrenal enlargement. The patient underwent surgical treatment by retroperitoneoscopic left radical nephrectomy plus adrenalectomy. A large number of typical spindle cells surrounded by plasma cells and lymphocytes were observed microscopically. Immunohistochemical analyses indicated that these spindle cells were positive for vimentin, cytokeratin (CK), Ki-67, CK7, CD34, and CD31 and were focally positive for CD10 and anaplastic lymphoma kinase (ALK-1). Thus, a diagnosis of IMT was made definitively. The patient recovered well after operation, and no recurrence or metastasis was noted during the 22-mo follow-up.CONCLUSIONSince kidney IMT is very rare and lacks characteristic clinical manifestation, it is easily misdiagnosed as a malignant tumor before operation. Surgery remains the best choice for diagnosis and treatment, and such cases must be followed carefully because of the uncertain biological behavior of this tumor. This report suggests that renal calculus may be one of the causes of IMT, but further investigation is necessary to prove it.

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“…It is rarely seen in the urinary tract. It has a low recurrence rate and rarely metastasizes [9,20,21]. The lung is the most common site of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…The inhibitor of anaplastic lymphoma kinase inhibitor, crizotinib, has been used for these patients [4]. One of the reported patients with inflammatory myofibroblastic tumor had received crizotinib and showed a complete response [9].…”

Section: Discussionmentioning

confidence: 99%

Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey

et al. 2019

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Background/aim: Non-Wilms renal tumors (NWRTs) are rarely encountered in children. The aim of this study is to determine the treatment strategies, prognosis, outcomes, and survival of children with NWRTs at Erciyes University in Kayseri, Turkey. Materials and methods: Medical records of all patients (n = 20) treated for NWRTs over a 23-year period (1995-2018) were reviewed retrospectively. Results: There was male predominance (female/male: 7/13); the median age at diagnosis was 3.2 years old (0.1-13.5 years old). The major histological groups included mesoblastic nephroma (MBN), (n: 5, 25%), malignant rhabdoid tumor (MRT), (n: 5, 25%), renal cell carcinoma, (n: 3, 15%), inflammatory myofibroblastic tumor (n: 2, 10%), multilocular cystic renal tumors (n: 2, 10%), metanephric adenoma (n: 1, 5%), renal neuroblastoma (n: 1, 5%), and bilateral renal Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) (n: 1, 5%). All of the patients with NWRTs had radical nephrectomy except the child with bilateral renal ES/PNET. Six children died because of progressive disease; the mortality rate was 30% (n: 6). Conclusion: We have made the first report of bilateral renal involvement of ES/PNET in the English medical literature. Physicians dealing with pediatric renal masses should be alert to the high mortality rate in children with MRT, MBN, and ES/PNET and they should design substantial management plans for NWRTs.

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Inflammatory Myofibroblastic Tumor of the Kidney and Bilateral Lung Nodules in a Child Mimicking Wilms Tumor With Lung Metastases

Cited by 11 publications

References 13 publications

Inflammatory myofibroblastic tumors in the kidney and abdominal wall mimicking malignancy

Inflammatory myofibroblastic tumors in the kidney and abdominal wall mimicking malignancy

Kidney inflammatory myofibroblastic tumor masquerading as metastatic malignancy: A case report and literature review

Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey

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