Inflammatory myofibroblastic tumor of small bowel wall in childhood: Report of a case and a review of the literature

Abstract

Benign intestinal tumors are rare in children, however we describe an inflammatory myofibroblastic tumor (IMT) of the jejunum in a 2-year-old girl who presented with an intestinal obstruction. During laparotomy, an annular mass around the jejunum was resected, from which a histological diagnosis of IMT was made. A review of the literature for this rare entity emphasizes the importance of histological confirmation of its benign nature. Because of the risk of local recurrence, IMT cases should have a long-term follow up.

Cardiac tumors in children- A review

“…The synonyms are plasma cell granuloma, inflammatory pseudotumor and possibly inflammatory fibrosarcoma. This tumor is characterized by fibroinflammatory and pseudomembranous appearance (Coffin et al, 1995;Demirkan et al, 2001); mostly occurring in children and young adults with a slight female gender predilection (male-to-female ratio being 3:4). Common site of occurrence is the lungs.…”

Abdominal inflammatory masses mimicking neoplasia in children—experience of two centers

“…Inflammatory pseudotumors (IPTs) are the most common among such processes. They are usually found in children and young adults and are most frequently found in the lungs, but they can occur in almost any organ, especially within the abdomen [1][2][3][4][5][6][7][8].…”

“…Plasma cells often predominate, but inconsistent proportions of lymphocytes (including lymphoid follicles), neutrophils, eosinophils, macrophages, and oval to spindle-shaped stromal cells have been found [2][3][4][5][6][7][8][9][10][11][12][13][14]. Inflammatory infiltrate can be confused with lymphomas or granulomatous lesions, especially if multinucleated giant cells and foamy histiocytes are found [2][3][4][5][6][7][8][9][10][11][12][13][14]. The stroma is typically quite fibrotic with a laminated appearance or dense sclerotic zones, which can be confused with sarcomas.…”

“…Myxoid foci may be present, but the vascular component is minimal [2][3][4][5][6][7][8][9][10][11][12][13][14]. Stromal cells usually have typical, immunohistochemical, and ultrastructural features of proliferating myofibroblasts, and for this reason IPTs are currently classified (according to the World Health Organization) as inflammatory myofibroblastic tumors [1][2][3][4][5][6][7][8][9]. Myofibroblasts are spindle cells sharing features of smooth muscle cells and fibroblasts and stain positively for vimentin, actin, and keratin in most cases [8,12].…”

“…In children, these tumors are typically localized in the liver, intestinal mesentery, or retroperitoneum, including the pelvis (especially the bladder). In the past these lesions seemed to be very unusual in children, but judging from recently emerging reports, they have been identified more frequently than previously thought [1][2][3][4][5][6][7][8]. However, their etiology is still obscure, and no clear causative factors have been identified.…”