Inflammatory metastic carcinoma. Carcinoma erysipelatoides

Hazelrigg, Donald E.

doi:10.1001/archderm.113.1.69

Cited by 27 publications

(9 citation statements)

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“…Metastasis cutis, recurring most frequently after breast cancer, exhibits as inflammatory, flat skin metastases in only 1% of cases (Krasnoff et al 1995). Tumours associated with other inflammatory skin metastases are anal tumours (Meadows & Egan 1999), lung or bronchial carcinoma (Hazelrigg & Rudolph 1977;Homler et al 1986), melanoma (Lindmaier & Wolfgang 1990;Böni et al 1997;Ozkan et al 1999), gastric cancer (Hariri et al 2000), pancreatic carcinoma, rectal carcinoma, ovarian/cervical carcinoma and parotid gland tumours. However, the presence of lymphoedema is often not mentioned in any of these cases.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Damstra

Jagtman

Steijlen

2009

European Journal of Cancer Care

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Lymphoedema is a clinical condition caused by impairment of the lymphatic system, leading to swelling of subcutaneous soft tissues. As a result, accumulation of protein-rich interstitial fluid and lymphostasis often causes additional swelling, fibrosis and adipose tissue hypertrophy leading to progressive morbidity and loss of quality of life for the patient. Lymphoedema can be distinguished as primary or secondary. Lymphoedema is a complication frequently encountered in patients treated for cancer, especially after lymphadenoectomy and/or radiotherapy based on destruction of lymphatics. However, although lymphatic impairment is sometimes caused by obstructive solid metastasis, we present three cases of secondary lymphoedema with minor dermatological features without detectable solid metastasis. Sometimes this type of lymphoedema is mistakenly called malignant lymphoedema. All patients were previously treated for cancer without clinical signs of recurrence, presented with progressive lymphoedema and minor dermatological features of unknown origin. Clinical and histopathological examination of the skin revealed diffuse lymphangitis carcinomatosa, leading to secondary lymphoedema and adjustment of the therapeutic approach and prognosis. We reviewed literature on these rare presentations of cancer recurrence and recommend, where appropriate, consulting a dermatologist when discrete skin abnormalities are seen in patients with a history of cancer and developing lymphoedema.

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Section: Discussion and Review Of Literaturementioning

confidence: 99%

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Damstra

Jagtman

Steijlen

2009

European Journal of Cancer Care

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“…In addition to our case, we identified eight other published cases of cutaneous lymphangitis carcinomatosa in patients with lung cancer [9][10][11][12][13][14][15][16] (Table 1). All but one patients suffered from lung adenocarcinoma (histology of lung cancer was not reported for one patient).…”

Section: Referencementioning

confidence: 99%

Cutaneous lymphangitis carcinomatosa in a patient with lung adenocarcinoma: Case report and literature review

et al. 2013

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“…3 The duration of the eruption, its failure to respond to antibiotic therapy, and the absence of leukocytosis, chills, and fever help to suggest the correct diagnosis; confirmation, however, requires a skin biopsy.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Cutaneous Metastasis from Rectal Adenocarcinoma

Melis

Scintu²,

Marongiu³

et al. 2002

Diseases of the Colon &Amp; Rectum

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Key words: Rectal adenocarcinoma; Inflammatory cutaneous metastasis] Melis M, Scintu F, Marongiu L, Mascia R, Frau G, Casula G. Inflammatory cutaneous metastasis from rectal adenocarcinoma: report of a case. Dis Colon Rectum 2002;45:562-563.C utaneous metastases occur in fewer than 4 percent of patients with colorectal adenocarcinoma. 1 Inflammatory cutaneous metastasis (ICM) is a rare subset of neoplastic disease, most often seen in patients with breast cancer, that usually presents clinically as a zone of pink, deep-red, or purplish-red indurated erythema with a well-demarcated border. 2 We recently observed a case of ICM that originated from a rectal cancer. REPORT OF A CASEA previously healthy 41-year-old male was referred to our department for a rectal adenocarcinoma that invaded the anal sphincter. Computed tomographic scan and endorectal ultrasound showed infiltration of the prostate and multiple metastases in both hepatic lobes; the patient underwent neoadjuvant chemoradiotherapy. A few weeks after completion of treatment, he developed an erythematous, well-demarcated eruption over the anterior pelvic region and the perineum. The eruption rapidly formed confluent erythematous plaques that were associated with pain and severe edema of scrotum, penis, and perineum (Fig. 1). Lymphedema of the lower extremities was not present; enlarged lymph nodes were palpable in both groins. Imaging did not reveal further dissemination of the disease, compared with the previous staging; specifically, no direct extension of the primary tumor to the abdominal or pelvic wall was noted. Biopsies of the skin showed metastasis of adenocarcinoma, with widespread dermal invasion and tumor cells plugging both lymphatic and vascular vessels. In the absence of tumor-related complications, we thought that surgery would be of no benefit to the patient in terms of survival and quality of life, and for this reason, he did not undergo surgery. DISCUSSIONCutaneous metastases very seldom present as erythematous, warm, well-demarcated and indurated

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Inflammatory metastic carcinoma. Carcinoma erysipelatoides

Cited by 27 publications

References 0 publications

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Cutaneous lymphangitis carcinomatosa in a patient with lung adenocarcinoma: Case report and literature review

Inflammatory Cutaneous Metastasis from Rectal Adenocarcinoma

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