Inflammatory Mediators and Vascular Events

Youlten, L. J. F.

doi:10.1007/978-3-642-66888-3_17

Cited by 7 publications

(7 citation statements)

References 34 publications

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“…Anti-inflammatory effects of mepyramine and methysergide have been reported as limited in some inflammatory models, such as thermal injury or carrageenin edema (8), when used in doses proved as effectively antagonize the amines. The doses of these antagonists used here would be enough to antagonize the effect of each amine (9,10), and the pleurisy induced by PMA may be a model where these amines have roles, since PMA has been proven to release histamine and 5 HT in vitro and in vivo to increase vascular permeability.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Histamine in Vascular Permeability Increase of the Rat Pleurisy Induced by Phorbol Myristate Acetate

Kikuchi

Oh‐ishi

1985

Japanese Journal of Pharmacology

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Section: Discussionmentioning

confidence: 99%

Involvement of Histamine in Vascular Permeability Increase of the Rat Pleurisy Induced by Phorbol Myristate Acetate

Kikuchi

Oh‐ishi

1985

Japanese Journal of Pharmacology

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“…Various clinical symptoms may exist for most of the ocular surface diseases. For example, mainly caused by the inflammation of the cornea, keratitis typically manifests as a defect of the corneal epithelium and even stromal infiltration, which could cause conjunctival vessel dilation, distortion and congestion, and even lead to abnormal blood vessel growth [4][5][6]. To establish complementary information for the diagnosis and treatment In this study, we developed a multi-modal non-invasive anterior eye imaging platform by combining our customized UHR-OCT and microvascular imaging system based on a functional slit-lamp biomicroscopy to provide both structural and functional information in ophthalmic clinical practice.…”

Section: Introductionmentioning

confidence: 99%

“…With ever-improving techniques in broadband light sources, ultra-high resolution OCT (UHR-OCT) has achieved micron-scale axial resolution [21,22]. UHR-OCT imaging of the ocular surface can now resolve and even measure the thickness of tear film and the major structures, such as the individual corneal layers: the epithelium, the Bowman's membrane, the Stroma, Descemet's membrane and the endothelium [23][24][25][26], which helps clinicians be better in the diagnosis and management of ocular surface pathologies and diseases, including keratitis [23,26], keratoconus [27], ocular surface neoplasia [28], etc.For ocular surface diseases, apart from the physiological structural changes, the microvascular system would also change when the eye is inflamed, as inflammatory mediators would induce a series of vascular changes, including vasodilation, increased permeability and increased blood flow [5,6], which correlates with the severity of the lesion. Techniques like OCT angiography [29,30] have been applied to image the vessels of the anterior segment, but they could only provide morphological information and lack of the function of providing quantitative functional parameters, such as the blood flow velocity.…”

mentioning

confidence: 99%

“…For ocular surface diseases, apart from the physiological structural changes, the microvascular system would also change when the eye is inflamed, as inflammatory mediators would induce a series of vascular changes, including vasodilation, increased permeability and increased blood flow [5,6], which correlates with the severity of the lesion. Techniques like OCT angiography [29,30] have been applied to image the vessels of the anterior segment, but they could only provide morphological information and lack of the function of providing quantitative functional parameters, such as the blood flow velocity.…”

mentioning

confidence: 99%

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Multi-modal Anterior Eye Imager Combining Ultra-High Resolution OCT and Microvascular Imaging for Structural and Functional Evaluation of the Human Eye

et al. 2020

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To establish complementary information for the diagnosis and evaluation of ocular surface diseases, we developed a multi-modal, non-invasive optical imaging platform by combining ultra-high resolution optical coherence tomography (UHR-OCT) with a microvascular imaging system based on slit-lamp biomicroscopy. Our customized UHR-OCT module achieves an axial resolution of ≈2.9 µm in corneal tissue with a broadband light source and an A-line acquisition rate of 24 kHz with a line array CCD camera. The microvascular imaging module has a lateral resolution of 3.5 µm under maximum magnification of ≈187.5× with an imaging rate of 60 frames/s, which is sufficient to image the conjunctival vessel network and record the movement trajectory of clusters of red blood cells. By combining the imaging optical paths of different modules, our customized multi-modal anterior eye imaging platform is capable of performing real-time cross-sectional UHR-OCT imaging of the anterior eye, conjunctival vessel network imaging, high-resolution conjunctival blood flow videography, fluorescein staining and traditional slit-lamp imaging on a single device. With self-developed software, a conjunctival vessel network image and blood flow videography were further analyzed to acquire quantitative morphological and hemodynamics parameters, including vessel fractal dimensions, blood flow velocity and vessel diameters. The ability of our multi-modal anterior eye imager to provide both structural and functional information for ophthalmic clinical applications was demonstrated on a healthy human subject and a keratitis patient. evaluation of ocular surface diseases, different imaging modalities are usually applied in ophthalmic clinics to provide multi-modal and multi-dimensional images [7,8].Slit-lamp biomicroscopy (SLB) is the gold standard for routine ophthalmic examinations. By shining a thin sheet of light into the eye, an in vivo stereoscopic evaluation of the pathological changes of the cornea, conjunctiva and other anterior segment tissues can be performed by SLB [9]. However, the limited magnification and poor spatial resolution of traditional SLB make it difficult to visualize more detailed pathological structures and perform accurate biometric measurements [10][11][12]. Fluorescein stain could stain stroma while leaving the intact epithelium with a specific fluorescein dye, thereby demarcating the location and area of the epithelial loss in ocular surface diseases, on a relative macro scale as well [13]. Developed in the 1990s, optical coherence tomography (OCT) has revolutionized the field of ophthalmology and vision science with its non-contact, non-invasive and high-resolution nature and become one of the prominent diagnostic tools in offering cross-sectional tissue imaging [14][15][16]. Applications of OCT for in vivo human eye imaging have been widely demonstrated in the literature [17][18][19][20][21][22][23][24][25][26][27][28]. With ever-improving techniques in broadband light sources, ultra-high resolution OCT (UHR-OCT) has achieved m...

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“…This process can be readily studied by measuring the tissue content of an isotopically labelled protein or a protein-bound dye at different times after injection of the inflammatory agent [1]. A direct relationship between the formation of oedema and an increase of vascular permeability of the tissue surrounding the injury was observed when high doses (500/zg-10 mg) of carrageenan were injected into the hind paw [2,3] but not with doses lower than 100 #g [4].…”

Section: Introductionmentioning

confidence: 99%

Chronobiological study of plasma exudation in carrageenan-paw oedema in the rat

et al. 1984

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The time-courses of exudation of protein-bound Evans' blue and of the formation of oedema following the injection of carrageenan (2 mg) or normal saline in the rat hind paw at 10.00 hours and 21.00 hours were studied. During the first 90 min after the carrageenan injection, the tissue content of the dye and the oedema formed were much greater when the inflammatory agent was administered at 21.00 hours than at 10.00 hours. A second study carried out at every 3 hours of the 24 hour span showed the presence of a circadian rhythm in the exudation of protein in the paw and in the formation of oedema. The paw volume and content of the dye were found to be highest between 19.00 hours and 01.00 hours whereas the minimal values were obtained at 16.00 hours. There is a correlation between the exudation of plasma proteins and the formation of oedema.

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Inflammatory Mediators and Vascular Events

Cited by 7 publications

References 34 publications

Involvement of Histamine in Vascular Permeability Increase of the Rat Pleurisy Induced by Phorbol Myristate Acetate

Involvement of Histamine in Vascular Permeability Increase of the Rat Pleurisy Induced by Phorbol Myristate Acetate

Multi-modal Anterior Eye Imager Combining Ultra-High Resolution OCT and Microvascular Imaging for Structural and Functional Evaluation of the Human Eye

Chronobiological study of plasma exudation in carrageenan-paw oedema in the rat

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