Chronobiological study of plasma exudation in carrageenan-paw oedema in the rat

Labrecque, Gaston; Doré, François Y.; Bélanger, Patrick; Carter, Vivian

doi:10.1007/bf01978914

Cited by 11 publications

(4 citation statements)

References 9 publications

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“…Moreover the data obtained after 480 minutes showed a second peak of PMN migration at 17.00. These results confirm the work of Labrecque et al [8] who showed a circadian rhythm of plasma exudation in carrageenan paw oedema in the rat. Nevertheless plasma exudation happened earlier than the PMN migration.…”

supporting

confidence: 95%

“…We identified previously the circadian variations of PMN migration in response to BCG in normal and adrenalectomized mice [5,6]. On an other hand Labrecque et al [7,8] described circadian variations in plasma exudate and paw oedema induced by carrageenan. Thus, it is of interest to determine whether circadian variation could be found in the migration of PMN produced by carrageenan injection.…”

Section: Introductionmentioning

confidence: 92%

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Temporal study of carrageenan-induced PMN migration in mice

Garrelly¹,

Bureau²,

Labreque

1991

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The time course of polymorphonuclear neutrophil (PMN) migration in an experimental inflammatory granuloma induced by carrageenan in the mice was studied at 6 different times of the day. Compared to saline, the number of PMN increased as soon as 240 min and reached high level at 480 min when migration was induced by carrageenan. The data showed circadian variations in the time course of cell migration. After 240 and 360 minutes of migration, the number of PMN was highest in the cell trap implanted at 09.00 whereas minimum values were obtained at 01.00. After 480 minutes of implantation, the PMN migration was maximal when the carrageenan experiment was performed at 05.00 and minimum values were obtained at 13.00. Thus, a significant rhythm was demonstrated in the time course of PMN migration.

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supporting

confidence: 95%

Section: Introductionmentioning

confidence: 92%

Temporal study of carrageenan-induced PMN migration in mice

Garrelly¹,

Bureau²,

Labreque

1991

Agents and Actions

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“…In the E rats, EVLW is more severe and mortality more frequent when C/D exposure is timed during the D span, indicating a greater stress-induced response on the body, including death, when it is applied during this circadian stage (i.e., the first half of the daily activity span). It is of interest that circadian studies on the induced inflammatory response in rats after injection with carrageenan (a colloid extracted from various red algae and especially Irish moss and commonly used as a suspending agent in foods and pharmaceuticals) also found the maximal response-as measured by the exudation of protein in the paw and in the formation of edema-when administered during the first half of the D span (13 and 19 HALO) (Labrecque et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

“…This phenomenon, called chronotoxicity or chronomodulation, is also known as the "hours of diminished resistance" (Halberg, 1960) or "hours of changing responsiveness or susceptibility" (Reinberg, 1967), and is the result of an organism's predictive rather than reactive homeostasis (Moore-Ede, 1986). Examples include circadian rhythmic inflammatory responses to various chemical stimuli in rats (Labrecque, et al, 1981(Labrecque, et al, , 1984Loubaris et al, 1983;Soliman, et al, 1983) and humans, including the cutaneous erythema and induration responses to intradermal injection (as challenges) of house dust, penicillin, or grass pollen (Lee et al, 1977;Reinberg et al, 1969), and response of the airways of sensitized Circadian Rhythms and Decompression Sickness 139 individuals to aerosol challenge with house dust and other allergens (Jarjour, 1999).…”

Section: Introductionmentioning

confidence: 99%

Circadian Study of Decompression Sickness Symptoms and Response-Associated Variables in Rats

Butler¹,

Little²,

Sothern

et al. 2010

Chronobiology International

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In order to study circadian rhythms and decompression sickness (DCS), we determined: 1) the baseline circadian time structure in noncompressed rats of potential response variables to compression/decompression (C/D), and 2) whether rats subjected to C/D display a circadian time-dependent difference in inflammatory response intensity and biological tolerance. Subgroups of male rats, standardized to a 12 h light/12 h dark schedule, were evaluated every 4 h over 24 h after they were either compressed to 683 kPa (group E) or remained at sea level (group C). During 60 min recovery, evaluation included gross DCS symptoms and pulmonary edema in all E rats, and cell counts, nitric oxide, protein, thromboxane B(2,) and leukotriene E(4) levels in survivors. Chi-square, ANOVA, and 24 h cosinor analyses were used to test for time-of-day effects. C/D exposures near the end of dark/activity or during light/resting were generally better tolerated, with lowest signs of DCS symptoms and lowest responses by most of the variables monitored. More deaths were observed in the first half of the dark/activity span. Of the 16 subsets of inflammatory-associated variables, overall increases were observed in 13 and decreases in 2. Significant or borderline significant circadian time effects were found in 14 variables in group C, 12 variables in group E, and 13 variables in response (E%C). Thus, nearly all baseline indices of DCS demonstrated circadian time-dependencies in the sea-level exposed control rats (group C), and nearly all were modified by the circadian time of C/D. Such time-of-day effects of DCS are potentially relevant to the operational concerns of occupations involving decompression exposures and the investigation of prevention and treatment intervention strategies of DCS.

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Ability of a benign tumor to decrease spontaneous food intake and body weight in rats

Kawashima¹,

Campos²,

Meguid³

et al. 1989

Cancer

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Malignant tumors induce anorexia and decrease spontaneous food intake and weight loss. Whether these effects are in part due to the tumor's physical size was investigated by inducing a benign cystic tumor mass with carrageenan in rats and then studying them for 21 days. Forty-two control rats were given subcutaneous injection of 3 ml of normal saline. Fifty-six study rats were given 3 ml of a 1.5% carrageenan solution subcutaneously, both in the right flank. Daily spontaneous food intake, body weight, and tumor weight were measured. Eight study and six control rats were randomly sacrificed on days 1, 3, 5, 7, 10, 14, and 21. Blood was obtained by cardiac puncture for albumin determination, and the tumor, carcass, liver, and spleen were removed and weighed. Tumor and tissue samples were histologically examined. All rats injected with carrageenan developed a benign cystic tumor mass. Early cystic wall consisted mainly of foamy macrophages with a light lymphoplasmacytic chronic inflammatory infiltrate and moderate vascularization. At day 21, cystic wall was more compact. The vasculature had collapsed and there were more pronounced fibroblastic response and collagen bundles. Average tumor weight by day 21 was 41 g. Average spontaneous food intake was depressed by about 15% from day 8 on in study rats as compared to controls. A significant decrease in carcass weight of 15.2% was observed in study as compared to control rats at day 21. Serum albumin was significantly decreased in study rats after day 5. Liver weight was significantly lower and spleen weight higher in study rats as compared to controls. These data suggest that some characteristics associated with cancer anorexia can be found in the absence of malignancy.

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Chronobiological study of plasma exudation in carrageenan-paw oedema in the rat

Cited by 11 publications

References 9 publications

Temporal study of carrageenan-induced PMN migration in mice

Temporal study of carrageenan-induced PMN migration in mice

Circadian Study of Decompression Sickness Symptoms and Response-Associated Variables in Rats

Ability of a benign tumor to decrease spontaneous food intake and body weight in rats

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