Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength

Schaap, Laura A.; Pluijm, Saskia M. F.; Deeg, Dorly J. H.; Visser, Marjolein

doi:10.1016/j.amjmed.2005.10.049

Cited by 809 publications

(604 citation statements)

References 42 publications

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“…thus sarcopenia may be a pathway by which endothelial dysfunction may contribute to poorer functional status reported in other studies (37). the lack of association between D-dimer, iL-6 and homocysteine and low MAMc/FFMi supports evidence showing no consistent association between high iL-6 and sarcopenia (38), but is contrary to research showing associations between these three biomarkers and sarcopenia (34,35). the study's major strength is the use of two clinically available and easily measurable markers of muscle mass to identify lifestyle, dietary and cardiovascular risk factors.…”

Section: Low Muscle Mass In Older Men: the Role Of Lifestyle Diet Anmentioning

confidence: 53%

Low muscle mass in older men: The role of lifestyle, diet and cardiovascular risk factors

Atkins

Whincup

Morris

et al. 2014

The Journal of nutrition, health and aging

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Section: Low Muscle Mass In Older Men: the Role Of Lifestyle Diet Anmentioning

confidence: 53%

Low muscle mass in older men: The role of lifestyle, diet and cardiovascular risk factors

Atkins

Whincup

Morris

et al. 2014

The Journal of nutrition, health and aging

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“…Soy isoflavones, acting as phytoestrogens, may have a positive effect on muscle mass because of their affinity for estrogen receptor-␣, which is found on muscle [21], or may exert their effects on reducing inflammation [22][23][24] associated with muscle protein degradation [25][26][27][28]. Besides soy isoflavones, other soy constituents such as protein may affect muscle mass [29].…”

Section: Discussionmentioning

confidence: 99%

Legumes and soy products consumption and functional disability in older women

Kim

Lee

2011

Maturitas

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“…High levels of inflammatory cytokines have been demonstrated to be negatively related to muscle strength and mass [10], [11]. However, the research considering whether their serum cytokine levels could represent a biological marker of sarcopenia is equivocal [12].…”

Section: Introductionmentioning

confidence: 99%

Inflammation and sarcopenia: A systematic review and meta-analysis

et al. 2017

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Nicola.Inflammation and sarcopenia: A systematic review and meta-analysis.Maturitas http://dx.doi.org/10.1016/j.maturitas. 2016.11.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights Sarcopenia is associated with functional impairment and adverse outcomes.  Highly inflammatory cytokines are negatively related to muscle strength and mass.  Sarcopenia is associated with higher serum inflammatory parameters.  Chronic inflammation could play a role in sarcopenia. AbstractInflammatory cytokines have been shown to prompt muscle wasting, ultimately stimulating protein catabolism and suppressing muscle synthesis. However, the possible association between inflammatory parameters and sarcopenia is poorly understood. We therefore aimed to summarize the current evidence about this topic with a meta-analysis of studies reporting serum inflammatory parameters in patients with sarcopenia vs. people without sarcopenia (controls). An electronic PubMed and Scopus search through to 09/01/2016 and meta-analysis of cross-sectional studies comparing serum levels of inflammatory cytokines between patients with sarcopenia and controls was made, calculating random-effects standardized mean differences (SMDs) ±95% confidence intervals (CIs) as the effect size. Out of 1370 initial hits, 17 studies with a total of 11249 participants (3072 with sarcopenia and 8177 without) were meta-analysed. Sarcopenic participants had significantly higher levels of CRP (SMD=0.51; 95%CI 0.26, 0.77; p<0.0001; I 2 =96%) than controls. Conversely, serum IL6 levels were not significantly different (SMD=0.35; 95%CI: -0.19, 0.89; p=0.21; I 2 =97%) in people with sarcopenia versus controls. Sarcopenic people did not have higher levels of TNF-than controls (SMD=0.28; 95%CI -0.26, 0.83; p=0.31; I 2 =97%). In conclusion, sarcopenia seems to be associated with elevated serum CRP levels; future longitudinal studies are needed to clarify this relationship.

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Inflammatory Markers and Loss of Muscle Mass (Sarcopenia) and Strength

Cited by 809 publications

References 42 publications

Low muscle mass in older men: The role of lifestyle, diet and cardiovascular risk factors

Low muscle mass in older men: The role of lifestyle, diet and cardiovascular risk factors

Legumes and soy products consumption and functional disability in older women

Inflammation and sarcopenia: A systematic review and meta-analysis

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