Inflammatory hallmarks in 6-OHDA- and LPS-induced Parkinson's disease in rats

Oliynyk, Zhanna; Rudyk, Mariia; Dovbynchuk, Taisa; Dzubenko, Nataliia; Tolstanova, Ganna; Skivka, Larysa

doi:10.1016/j.bbih.2023.100616

Cited by 8 publications

(6 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study has shown that 6-OHDA can cause anxiety-like behaviors in rats with Parkinson's disease (PD). As discussed before, anxiety is one of the illnesses that can be linked to ASD ( Vieira et al, 2019 , Oliynyk et al, 2023 ). The findings of our study suggest that the combined treatment of 6-OHDA and LPS resulted in a more pronounced increase in VPA-induced autism-like behaviors compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model

Alhamami,

Albogami,

Algahtani

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model

Alhamami,

Albogami,

Algahtani

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

“…In the 6-OHDA-induced PD model, increased microglial activation was found to precede the loss of DA neurons, suggesting that phagocytic microglia may prematurely engulf degenerating neurons [138]. 6-OHDA destroys nigrostriatal dopaminergic neurons, causing motor and biochemical dysfunctions in PD [58,139]. In the microglia and macrophage ratios taken from 6-OHDA lesioned rats, decreases in the ratio of CD80/86+ cells were observed, while the increased fraction of CD206+ cells was noted [58].…”

Section: Tissue Infiltrationmentioning

confidence: 98%

“…However, it should be noted that interhemispheric compensation may occur, and even DA levels on the contralateral side have been shown to increase after a 6-OHDA lesion [56]. The main disadvantage of the 6-OHDA model is its relatively rapid development and the absence of real progression of the pathology, with transient and low-grade neuroinflammation [57,58]. Another pitfall is the fact that this model is not suitable for examination of the role of immune cells in PD development and progression due to the nature of the induction.…”

Section: Advantages and Disadvantages Of Toxin-induced Experimental Pdmentioning

confidence: 99%

“…6-OHDA destroys nigrostriatal dopaminergic neurons, causing motor and biochemical dysfunctions in PD [58,139]. In the microglia and macrophage ratios taken from 6-OHDA lesioned rats, decreases in the ratio of CD80/86+ cells were observed, while the increased fraction of CD206+ cells was noted [58]. However, in the MPTP model, inflammatory markers in the SN, such as HLA-DR-positive reactive microglia and infiltrations of T lymphocytes, including CD8+T cells and CD4+T cells, were observed by immunohistochemistry and electron microscopy [94,135,140].…”

Section: Tissue Infiltrationmentioning

confidence: 99%

See 1 more Smart Citation

Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease

Saponjic,

Mejías,

Nikolovski

et al. 2024

IJMS

View full text Add to dashboard Cite

Parkinson’s disease (PD) is a chronic, age-related, progressive multisystem disease associated with neuroinflammation and immune dysfunction. This review discusses the methodological approaches used to study the changes in central and peripheral immunity in PD, the advantages and limitations of the techniques, and their applicability to humans. Although a single animal model cannot replicate all pathological features of the human disease, neuroinflammation is present in most animal models of PD and plays a critical role in understanding the involvement of the immune system (IS) in the pathogenesis of PD. The IS and its interactions with different cell types in the central nervous system (CNS) play an important role in the pathogenesis of PD. Even though culture models do not fully reflect the complexity of disease progression, they are limited in their ability to mimic long-term effects and need validation through in vivo studies. They are an indispensable tool for understanding the interplay between the IS and the pathogenesis of this disease. Understanding the immune-mediated mechanisms may lead to potential therapeutic targets for the treatment of PD. We believe that the development of methodological guidelines for experiments with animal models and PD patients is crucial to ensure the validity and consistency of the results.

show abstract

“…Various inflammatory stimuli such as LPS are able to initiate different chronic inflammatory diseases (Oliynyk et al., 2023). Rosemary extracts, which were rich in carnosic acid derivatives, can significantly reduce the capability of LPS‐stimulated RAW 264.7 cells to produce NO (Brindisi et al., 2020).…”

Section: Biological Activities Of Rosemary Extractmentioning

confidence: 99%

Rosemary: Unrevealing an old aromatic crop as a new source of promising functional food additive—A review

Qiu,

Wang,

Duan

et al. 2024

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Rosemary (Rosmarinus officinalis L.) is one of the most famous spice plants belonging to the Lamiaceae family as a remarkably beautiful horticultural plant and economically agricultural crop. The essential oil of rosemary has been enthusiastically welcome in the whole world for hundreds of years. Now, it is wildly prevailing as a promising functional food additive for human health. More importantly, due to its significant aroma, food, and nutritional value, rosemary also plays an essential role in the food/feed additive and food packaging industries. Modern industrial development and fundamental scientific research have extensively revealed its unique phytochemical constituents with biologically meaningful activities, which closely related to diverse human health functions. In this review, we provide a comprehensively systematic perspective on rosemary by summarizing the structures of various pharmacological and nutritional components, biologically functional activities and their molecular regulatory networks required in food developments, and the recent advances in their applications in the food industry. Finally, the temporary limitations and future research trends regarding the development of rosemary components are also discussed and prospected. Hence, the review covering the fundamental research advances and developing prospects of rosemary is a desirable demand to facilitate their better understanding, and it will also serve as a reference to provide many insights for the future promotion of the research and development of functional foods related to rosemary.

show abstract

Inflammatory hallmarks in 6-OHDA- and LPS-induced Parkinson's disease in rats

Cited by 8 publications

References 75 publications

The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model

The effect of inhibiting hindbrain A2 noradrenergic neurons by 6-Hydroxydopamine on lipopolysaccharide-treated male rats autistic animal model

Experimental Models to Study Immune Dysfunction in the Pathogenesis of Parkinson’s Disease

Rosemary: Unrevealing an old aromatic crop as a new source of promising functional food additive—A review

Contact Info

Product

Resources

About