Inflammatory cytokines regulate the expression of glycosyltransferases involved in the biosynthesis of tumor-associated sialylated glycans in pancreatic cancer cell lines

Bassagañas, Sònia; Allende, Helena; Cobler, Lara; Ortiz, Rosa; Llop, Esther; Bolós, Carme de; Peracaula, Rosa

doi:10.1016/j.cyto.2015.04.006

Cited by 55 publications

(36 citation statements)

References 64 publications

(63 reference statements)

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“…Our previous study has shown that NCOA3 upregulates the expression of fucosyltransferase 8 (FUT8) in PC cells. Fucosyltransferase expression in PC is associated with the increased expression of sialyl-Lewis a/x on the cancer cells [54], which act as the ligands for the selectins, present on the surface of endothelial cells, therefore, facilitating the interaction between cancer and endothelial cells during extravasation step of metastasis [54]. Further, fucosylation is also associated with the stem cell-like phenotype and the malignant transformation of intraductal papillary mucinous lesions [55].…”

Section: Resultsmentioning

confidence: 99%

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

et al. 2016

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Pancreatic cancer (PC) is one of the most aggressive malignancies due to intense desmoplasia, extreme hypoxia and inherent chemoresistance. Studies have implicated the expression of chemokine receptor CXCR4 and nuclear receptor co-activator-3 (NCOA3) in the development of desmoplasia and metastatic spread of PC. Using a series of polymeric CXCR4 antagonists (PCX), we optimized formulation of PCX/siNCOA3 polyplexes to simultaneously target CXCR4 and NCOA3 in PC. Cholesterol-modified PCX showed maximum CXCR4 antagonism, NCOA3 silencing and inhibition of PC cell migration in vitro. The optimized PCX/siNCOA3 polyplexes were used in evaluating antitumor and antimetastatic activity in orthotopic mouse model of metastatic PC. The polyplexes displayed significant inhibition of primary tumor growth, which was accompanied by a decrease in tumor necrosis and increased tumor perfusion. The polyplexes also showed significant antimetastatic effect and effective suppression of metastasis to distant organs. Overall, dual-function PCX/siNCOA3 polyplexes can effectively regulate tumor microenvironment to decrease progression and dissemination of PC.

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Section: Resultsmentioning

confidence: 99%

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

et al. 2016

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“…In this regard, note that the novel proinflammatory biomarker GlycA has been shown to be positively related to Lp-PLA 2 in subjects without T2DM or the metabolic syndrome (39). In view of the effect of Lp-PLA 2 to increase ILs, which are able to enhance protein glycosylation (40)(41)(42)(43), it is conceivable that Lp-PLA 2 could be involved in the association of sodium intake with plasma GlycA concentrations.…”

Section: Figure 1 Association Between Sodium Excretion (Mmol/24-h) Andmentioning

confidence: 96%

GlycA, a novel proinflammatory glycoprotein biomarker, and high-sensitivity C-reactive protein are inversely associated with sodium intake after controlling for adiposity: the Prevention of Renal and Vascular End-Stage Disease study

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et al. 2016

The American Journal of Clinical Nutrition

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“…Pro-inflammatory cytokines can increase the expression of glycosyltransferases involved in the biosynthesis of cancer-associated antigens in pancreatic and gastric cancer cell lines [143, 144]. …”

Section: Tumour Promoting Inflammationmentioning

confidence: 99%

Hallmarks of glycosylation in cancer

2016

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Aberrant glycosylation plays a fundamental role in key pathological steps of tumour development and progression. Glycans have roles in cancer cell signalling, tumour cell dissociation and invasion, cell-matrix interactions, angiogenesis, metastasis and immune modulation. Aberrant glycosylation is often cited as a ‘hallmark of cancer’ but is notably absent from both the original hallmarks of cancer and from the next generation of emerging hallmarks. This review discusses how glycosylation is clearly an enabling characteristic that is causally associated with the acquisition of all the hallmark capabilities. Rather than aberrant glycosylation being itself a hallmark of cancer, another perspective is that glycans play a role in every recognised cancer hallmark.

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Inflammatory cytokines regulate the expression of glycosyltransferases involved in the biosynthesis of tumor-associated sialylated glycans in pancreatic cancer cell lines

Abstract: The inflammatory microenvironment can modulate the glycosylation pattern of PDAC cells, increasing the expression of tumor-associated sialylated antigens such as SLe(x), which contributes to pancreatic tumor malignancy.

Cited by 55 publications

References 64 publications

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

GlycA, a novel proinflammatory glycoprotein biomarker, and high-sensitivity C-reactive protein are inversely associated with sodium intake after controlling for adiposity: the Prevention of Renal and Vascular End-Stage Disease study

Hallmarks of glycosylation in cancer

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