Inflammatory Cytokines and Sleep Disturbance in Patients with Temporomandibular Disorders

Park, Ji Woon; Chung, Jin Woo

doi:10.11607/ofph.1367

Cited by 54 publications

(105 citation statements)

References 0 publications

Supporting

Mentioning

102

Contrasting

Order By: Relevance

“…Secondly, OSA patients usually display chronic intermittent hypoxemia, which increases the levels of inflammatory cytokines, contributing to the pathogenesis of multiple comorbidities [ 26 ]. As higher plasma levels of inflammatory cytokines were reported both in OSA and TMD [ 27 , 28 ], we postulated that OSA might contribute to the pathogenesis of TMD through enhancing systemic inflammation. It is therefore not surprising that SA patients have higher TMD incidence.…”

Section: Discussionmentioning

confidence: 85%

The Association between Temporomandibular Disorder and Sleep Apnea—A Nationwide Population-Based Cohort Study

Lee

Kuo

et al. 2020

IJERPH

View full text Add to dashboard Cite

An increased incidence of temporomandibular disorders (TMD) among patients with sleep apnea (SA) has been reported. However, the association between TMD and SA has not been demonstrated in a large-scale study. This population-based cohort study with the Taiwan National Health Insurance (NHI) Research Database aimed to understand the association between SA and TMD. We identified adult patients with suspected SA (identified with diagnostic codes) and excluded those diagnosed with TMD prior to SA. Patients with SA diagnosis after polysomnography were also identified as probable SA patients. The index dates were the dates of their initial SA diagnosis. Ten control subjects were matched, by age and sex, to each SA patient, and were assigned the same index dates as the SA patients. In total, 10,408 suspected SA patients (including 4105 probable SA patients) matched to 104,080 control subjects (including 41,050 subjects matched to the probable SA patients) in this study. The TMD incidence rate was significantly higher in the SA patients than in the control subjects (2.8 vs. 1.0 per thousand-patient-year in probable SA patients vs. the corresponding control subjects, with an adjusted incidence rate ratio [95% confidence interval] = 2.5 [2.3–2.7], p < 0.0001). SA patients significantly showed a higher cumulative incidence of TMD than the corresponding control subjects (p < 0.0001). Multivariable Cox regression analysis revealed SA as an independent risk factor for the development of TMD (adjusted hazard ratio = 2.5 [1.7–3.7], p < 0.0001). In summary, this study confirmed an increased TMD incidence in the SA patients. While treating TMD patients, dentists should pay careful attention to the potential underlying SA.

show abstract

Section: Discussionmentioning

confidence: 85%

The Association between Temporomandibular Disorder and Sleep Apnea—A Nationwide Population-Based Cohort Study

Lee

Kuo

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Despite the etiological factor associated with the psychosocial sphere, this provides valuable information for proper diagnosis, and correct treatment of temporomandibular joint dysfunction is primarily occlusal splint, correction of occlusal contact, and numerous supporting physiotherapy treatments, such as biostimulation laser, sonophoresis, and manual techniques [ 1 , 2 , 5 , 25 – 28 ].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of C-Reactive Protein Level in Patients with Pain Form of Temporomandibular Joint Dysfunction

Pihut

Ceranowicz

Gala

2018

Pain Research and Management

View full text Add to dashboard Cite

Temporomandibular joint dysfunction is a functional disorder concerned with the abnormal functioning of the muscles of the stomatognathic system and temporomandibular joints involved in the dynamic movements of the jaw and surrounding structures. The aim of the study was to compare the level of C-reactive protein in patients with pain and painless forms of temporomandibular joint dysfunction. Materials and methods. The study group consisted of 72 patients who reported to the prosthetic treatment because of temporomandibular joint dysfunction. The study group included 36 patients with pain form of dysfunction, and the control group included 36 patients with painless form of disorder. Each patient underwent specialized examination of functional disorders in order to diagnose the type of dysfunction and was commissioned to carry out a study of the blood test concerned with evaluation of the C-reactive protein (CRP) level in the same analytical laboratory. The results of the investigation were subjected to statistical analysis. The research obtained approval from the Ethics Committee of the Jagiellonian University (KBET/125/L/2013). Level of Evidence for primary research was established as type V. Results. The mean values of C-reactive protein levels in both groups were in the normal range and did not differ statistically significantly, which indicates the fact that the pain form of the temporomandibular joint disorders is not associated with inflammation of the soft tissues of the joint. Conclusion. Painful form of the temporomandibular joint dysfunctions is not connected with the inflammation of joints.

show abstract

“…Those with this genetic variant and comorbid UARS will be left with higher residual levels of circulating catecholamines which, in turn, promote pain sensitivity and proinflammatory cytokine release . Park and Chung found increased ESS and Pittsburgh Sleep Quality Index (PSQI) scores as well as elevated plasma cytokine levels of IL‐1 β , IL‐6, IL‐10 and TNF‐ α in 19% of a group of myofascial patients with TMD, especially those with high disability. Their results suggest that chronic inflammation could be the underlying mechanism for the association between sleep disturbance and persistent TMD .…”

Section: Discussionmentioning

confidence: 99%

“…Park and Chung found increased ESS and Pittsburgh Sleep Quality Index (PSQI) scores as well as elevated plasma cytokine levels of IL‐1 β , IL‐6, IL‐10 and TNF‐ α in 19% of a group of myofascial patients with TMD, especially those with high disability. Their results suggest that chronic inflammation could be the underlying mechanism for the association between sleep disturbance and persistent TMD . Thus in patients with UARS, the nightly airway challenge, in the form of repetitive episodes of progressively increasing inspiratory effort terminated by frequent transient arousals, could over time be responsible for the ‘faulty neuroception’ of their internal environment, gradually shifting their autonomic nervous systems into a continuous state of alert modulated by the sympathetic system, with the progressive withdrawal of the ventral vagal brake .…”

Section: Discussionmentioning

confidence: 99%

Clinical phenotype of South–East Asian temporomandibular disorder patients with upper airway resistance syndrome

Tay

Pang²

2017

J of Oral Rehabilitation

View full text Add to dashboard Cite

SUMMARY Clinical and radiographic characteristics of a subset of South East Asian temporomandibular disorder (TMD) patients with comorbid upper airway resistance syndrome (UARS) were documented in a multi-center prospective series of 86 patients (26 men and 60 women / mean age 35.7 years). All had excessive daytime sleepiness, high arousal index and Apnoea-Hypopnoea Index (AHI) <5. The mean body mass index was 20Á1, mean arousal index 16Á2, mean respiratory disturbance index 19Á6, mean AHI 3Á9 while the mean Epworth Sleepiness Scale was 14Á8. Many had functional somatic complaints; 66Á3% headaches, 41Á9% neck aches, 53Á5% masticatory muscle myalgia, 68Á6% temporomandibular joint (TMJ) arthralgia while 90Á7% reported sleep bruxism (SB). Unlike patients with obstructive sleep apnoea (OSA), hypertension was uncommon (4Á7%) while depression was prevalent at 68Á6% with short REM latency of <90 min and an increased REM composition >25% documented in 79Á6% and 57Á6% of these depressed patients, respectively. 65Á1% displayed a posteriorly displaced condyle at maximum intercuspation with or without TMJ clicking. Most exhibited a forward head posture (FHP) characterised by loss of normal cervical lordosis (80Á2%), C0-C1 narrowing (38Á4%) or an elevated hyoid position (50%), and 91Á9% had nasal congestion. We postulate the TMD-UARS phenotype may have originally developed as an adaptive response to 'awake' disordered breathing during growth. Patients with persistent TMD and/ or reporting SB should be screened for UARS and chronic nasal obstruction, especially when they also present with FHP. The lateral cephalogram is a useful tool in the differentiation of UARS from other OSA phenotypes.

show abstract

Inflammatory Cytokines and Sleep Disturbance in Patients with Temporomandibular Disorders

Abstract: Patients with TMD, especially those with high disability, had elevated plasma cytokine levels and increased ESS and PSQI scores suggestive of sleep disturbance.

Cited by 54 publications

References 0 publications

The Association between Temporomandibular Disorder and Sleep Apnea—A Nationwide Population-Based Cohort Study

The Association between Temporomandibular Disorder and Sleep Apnea—A Nationwide Population-Based Cohort Study

Evaluation of C-Reactive Protein Level in Patients with Pain Form of Temporomandibular Joint Dysfunction

Clinical phenotype of South–East Asian temporomandibular disorder patients with upper airway resistance syndrome

Contact Info

Product

Resources

About