Genetic epidemiology is a powerful discipline in genetic studies to investigate the geneenvironment interaction in causing diseases and their mode of inheritance within families. 1 Accurate and comprehensive genealogical and medical data are prerequisites for such research to generate evidence of familial aggregation of diseases and to test the mode of inheritance. These advances may aid clinicians to identify predispositions of individuals based on their family histories.Population-based genealogy databases with linked medical data greatly facilitate genetic research and clinical application. 2 However, good resources are rarely available for research and often have restrictions on access or linkages due to technical difficulties or privacy considerations. Comprehensive genealogies of the Utah 3 and Icelandic populations 4 are wellknown resources for research, with linkages to medical data in some of the participants. The Scotland 5 and the Scandinavian countries have established nationwide genealogical registries which contain demographic data and linkage to specific disease registries. 6 The resource is lacking in population of non-European descents.The National Health Insurance Research Database (NHIRD) contains comprehensive information on demographics, medical diagnoses, medical expenditure, details of prescriptions, examinations, and procedures of the entire population of Taiwan. In particular, relationships between beneficiaries are also available, which allows for genealogy reconstruction in a national level.

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