Inflammatory cell response to acute muscle injury

Tidball, James G.

doi:10.1249/00005768-199507000-00011

Cited by 417 publications

(373 citation statements)

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“…3b), histopathologic findings showed that HS reduced muscle injury after downhill running ( Table 1). The accumulation of leukocytes even in our C group (Table 1) supports previous findings that the presence of leukocytes in muscle tissue is necessary for both normal muscle function and tissue repair following injury [24]. Leukocyte infiltration to remove cell debris is important for the recovery of skeletal muscle from oxidative stress after exercise [25].…”

Section: Discussionsupporting

confidence: 88%

Effect of Heat Shock Preconditioning on ROS Scavenging Activity in Rat Skeletal Muscle after Downhill Running

et al. 2008

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Abstract:The mechanisms of the protective effect conferred by heat shock preconditioning (HS) are currently unknown. The purpose of this study was to determine the effect of HS on muscle injury after downhill running and to address the mechanism of the effect. Female Wistar rats were assigned to three groups: HS, downhill running (E), and downhill running after heat shock preconditioning (HS + E). The HS and HS + E rats were placed in a heat chamber for 60 min (ambient temperature 42 ± 1.0°C) 48 h before downhill running. Reactive oxygen species (ROS) scavenging activity was determined by electron spin resonance (ESR), and heat shock protein 72 (HSP72) mRNA expression was measured in rat quadriceps femoris. Leukocyte infiltration and degenerated muscle fibers were determined histopathologically. ROS scavenging activity significantly increased at 3 days after HS (151 ± 18%) and HSP72 mRNA expression increased immediately after HS (1750 ± 1914%). No decrease in ROS scavenging activity was observed in the HS + E rats at 2 days after exercise compared with the E rats (102 ± 9% vs. 79 ± 5%). Degenerated muscle fibers in HS + E rats were significantly less than in E rats at 2, 3, and 7 days after exercise (0.8 ± 1.0 vs. 2.8 ± 1.6, 0.8 ± 1.0 vs. 1.8 ± 1.6, 0 vs. 0.3 ± 0.6, respectively). These data demonstrated that HS can reduce muscle injury after downhill running, and this effect may be mediated by increased ROS scavenging activity. Furthermore, HS may protect the antioxidant defense system in skeletal muscle by enhancing the adaptive HSP72 mRNA response.

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Section: Discussionsupporting

confidence: 88%

Effect of Heat Shock Preconditioning on ROS Scavenging Activity in Rat Skeletal Muscle after Downhill Running

et al. 2008

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“…Although the mechanisms are not clearly understood, unaccustomed exercise or eccentric exercise often results in sarcomere and cell membrane disruption (25,59), signal infiltration of inflammatory cells to the injured tissue (1,30,53), and increased circulating inflammatory markers (12,18,44). Indeed, eccentric exercise temporarily impairs local microvascular function (21) and reduces vasodilator responses (16).…”

mentioning

confidence: 99%

Arterial stiffening following eccentric exercise-induced muscle damage

Barnes

Trombold

Dhindsa

et al. 2010

Journal of Applied Physiology

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“…This confirms that a damaging stimulus is ongoing in the muscle four days after the impact. This is possibly due to a local reperfusion type injury or 'second hit phenomenon' in which the severe injury activates inflammatory cells and as a consequence more damage is caused when the inflammatory cells invade areas of normal and necrotic tissue [5,14]. This was not seen in the small crush samples.…”

Section: Discussionmentioning

confidence: 99%

“…The balance, between inflammation of a degree necessary to initiate regeneration and excessive inflammation associated with poor muscle healing, scar formation and delayed fracture union, may be reflected in the production of inflammatory cytokines such as IL-1 P and TNF-a [14]. A model embodying controlled variation in the degree of inflammatory response, with examination of morphology and underlying cytokine expression, would provide useful insights into the role of inflammation in repair.…”

Section: Introductionmentioning

confidence: 99%

Production of consistent crush lesions in murine quadriceps muscle—A biomechanical, histomorphological and immunohistochemical study

Bunn

Canning

Burke

et al. 2004

Journal Orthopaedic Research

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Poor healing of high-energy fractures is often associated with severe muscle damage. This mdy be partly due to the production, by the injured muscle, of inflammatory cytokines that somehow misdirect bone healing. In order to investigate this question, an animal model was established which embodies a controlled degree of muscle injury with a dose response to the energy absorbed, that can be characterised histologically. Using a custom crush jig, 60 CFLP mice had either 100 or 200 g masses dropped from a fixed height onto the quadriceps muscle, with mechanical measurement of the impact. Energy of impact was reliably and significantly different between the small and large impact conditions, though there was more variability when the large mass was used. Animals were sacrificed at day 2,4, 8, 16, and 24 post-injury. Muscle histomorphometry at all time points and immunohistochemistry for ILlp, IL-6, and TNF-a up to day 8 were used as measures of muscle damage, inflammation and repair. Histological sections were analysed into areas of normal muscle fibres, damagedhegenerating muscle fibres and fibrous/inflammatory infiltrate. Early histological response was similar between the two groups; the large crush group displayed significantly greater areas of inflammatory infiltrate and damaged muscle at the later time points after day 8. In the large crush group, IL-lP and IL-6 expression were significantly higher at day 2 and TNF-a was higher at day 8 when compared to the small crush group.The experiment demonstrated that more severe injury to muscle was reliably followed by increased inflammatory cytokine production and a greater degree of inflammation and fibrosis. Increased production of inflammatory cytokines such as TNF-a and I t -l p in the damaged muscles may activate macrophages and recruit fibroblasts, promote scar formation and lead to delayed union or non-union of the adjacent fracture(s).

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Inflammatory cell response to acute muscle injury

Cited by 417 publications

References 0 publications

Effect of Heat Shock Preconditioning on ROS Scavenging Activity in Rat Skeletal Muscle after Downhill Running

Effect of Heat Shock Preconditioning on ROS Scavenging Activity in Rat Skeletal Muscle after Downhill Running

Arterial stiffening following eccentric exercise-induced muscle damage

Production of consistent crush lesions in murine quadriceps muscle—A biomechanical, histomorphological and immunohistochemical study

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