2010
DOI: 10.1152/japplphysiol.00548.2010
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Arterial stiffening following eccentric exercise-induced muscle damage

Abstract: Arterial stiffening following eccentric exercise-induced muscle damage.

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Cited by 77 publications
(78 citation statements)
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References 59 publications
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“…38 The subacute effects may persist upward of 2 weeks following exercise, 36 and exercise-induced muscle damage/inflammation is associated with subacute increases in arterial stiffness. 39 In conclusion, akin to what has been postulated with cardiac maladaptation, it is proposed herein that repetitive, sustained elevations of cardiac output for several hours in predisposed individuals causes fatigue fracture of elastin fibers and stimulates resident macrophages, pericytes, and fibroblasts, resulting in the deposition of collagen and vascular fibrosis, and an increase in arterial stiffness. This, coupled with bradycardia-induced augmented pressure from wave reflections and load-dependent increases in forward wave pressure, will increase pressure pulsatility, contributing to downstream endothelial damage, target organ damage (ie, LV hypertrophy and atrial enlargement), coronary ischemia, atrial fibrillation, and possible SCD.…”
mentioning
confidence: 74%
“…38 The subacute effects may persist upward of 2 weeks following exercise, 36 and exercise-induced muscle damage/inflammation is associated with subacute increases in arterial stiffness. 39 In conclusion, akin to what has been postulated with cardiac maladaptation, it is proposed herein that repetitive, sustained elevations of cardiac output for several hours in predisposed individuals causes fatigue fracture of elastin fibers and stimulates resident macrophages, pericytes, and fibroblasts, resulting in the deposition of collagen and vascular fibrosis, and an increase in arterial stiffness. This, coupled with bradycardia-induced augmented pressure from wave reflections and load-dependent increases in forward wave pressure, will increase pressure pulsatility, contributing to downstream endothelial damage, target organ damage (ie, LV hypertrophy and atrial enlargement), coronary ischemia, atrial fibrillation, and possible SCD.…”
mentioning
confidence: 74%
“…Previous studies have documented changes in arterial stiffness following both acute and chronic interventions, and acute changes have been detected in response to many stimuli other than diving or immersion [57,58,59,60,61]. Acute aerobic exercise (rowing) caused stiffness to decrease [62], and acute sprint interval exercise caused increased compliance but no change in brachial artery stiffness [63].…”
Section: Discussionmentioning
confidence: 99%
“…Hence, the observed differences in exercise-induced changes in CK activity and cytokine levels resulted from differences in absolute WL and the related mechanical stress/muscle damage. Other contributing factors might be the relative inefficiency of the muscle pump during ECC exercise as compared to that during CONC exercise [7], and ECC exercise-associated temporary impairment of local microvascular [18] and macrovascular function, in particular arterial stiffness [2], as well as reduced vasodilator response [15]. Hence, it is possible that, despite identical relative VO 2 values, oxygen delivery to the working muscles differed between the two types of exercise, which might have affected the extent of muscle damage and responses to the latter.…”
Section: Discussionmentioning
confidence: 99%