Inflammatory biomarkers for predicting cardiovascular disease

Stoner, Lee; Lucero, Adam; Palmer, Barry R.; Jones, Lynnette M.; Young, Joanna M.; Faulkner, J.

doi:10.1016/j.clinbiochem.2013.05.070

Cited by 147 publications

(119 citation statements)

References 411 publications

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“…Th us, the fi ndings of a recent study (Gregson, Drust, Atkinson, & Salvo, 2010) indicate that match-to-match variability in performance characteristics of elite soccer players is high. Moreover, many factors within the body can infl uence muscle damage, such as infl ammation (Stoner et al, 2013), nutrition (Muñoz & Costa, 2013), intake of supplements (Goldfarb, 1999;Goldfarb, Garten, Cho, Chee, & Chambers, 2011). A signifi cant increase in muscle damage markers (Andersson, Ekblom, & Krustrup, 2008;Ascensão et al, 2008;Ispirlidis et al, 2008;Magalhães et al, 2010) has been described immediately aft er "friendly" soccer matches and throughout the post-match recovery.…”

Section: Introductionmentioning

confidence: 99%

Post-Match Changes in Muscle Damage Markers among U-21 Soccer Players

Trajković¹,

Sporis²,

Vlahović³

et al. 2018

Monten. J. Sports Sci. Med.

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Th is study aimed to investigate the eff ect of offi cial soccer matches on selected markers of muscle damage in U-21 soccer players. A group of 19 trained, healthy male soccer players from the junior category took part in this study. Blood samples were assessed pre-match and immediately aft er a match in response to a competitive (2×45 min) soccer match. Analysis was performed for muscle damage and infl ammatory markers. Signifi cant diff erences between two measures (before and aft er soccer match) exist in Aspartate-aminotransferase (AST), Lactate dehydrogenase (LDH), and Myoglobin. Plasma K + signifi cantly decreased aft er the match (p<0.05), whereas plasma Na + decreased slightly. Th is study showed that most selected markers of muscle damage were infl uenced by a soccer match. However, results remain inconsistent because of the infl uence of the type, duration, and intensity of exercise. Moreover, some markers show great variability among individuals.

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Section: Introductionmentioning

confidence: 99%

Post-Match Changes in Muscle Damage Markers among U-21 Soccer Players

Trajković¹,

Sporis²,

Vlahović³

et al. 2018

Monten. J. Sports Sci. Med.

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“…Multiple lines of evidence suggest that both oxidative stress and inflammation participate in a vicious cycle that can lead to impaired vascular function and CAD (Wadley et al 2013). Chronic low-grade inflammation increases free radical production, causing oxidative stress in the cell (Mangge et al 2014;Soory 2012;Stoner et al 2013). This oxidative stress can further exacerbate the systemic inflammation at the cellular level, providing a basis for the progression of CAD.…”

Section: Introductionmentioning

confidence: 99%

Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation includingCitrus bergamia, in subjects with moderate cardiometabolic risk factors

Babish¹,

Dahlberg

et al. 2016

Can. J. Physiol. Pharmacol.

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Abstract:We examined the clinical safety and efficacy of F105 in 11 subjects with moderate dyslipidemia. F105 is a combination of bergamot fruit extract (Citrus bergamia, BFE) and 9 phytoextracts selected for their ability to improve the antioxidant and anti-inflammatory activity of BFE. In vitro F105 exhibited a synergistic inhibition of oxygen radical absorbing capacity, peroxynitrite formation, and myeloperoxidase activity. Following 12 weeks of F105 daily, no treatment-related adverse events or changes in body mass were seen. Statistically significant changes were noted in total cholesterol (−7.3%), LDL-cholesterol (−10%), non-HDL cholesterol (−7.1%), cholesterol/HDL (−26%), and apolipoprotein B (−2.8%). A post hoc analysis of 8 subjects with HbA1c > 5.4 and HOMA-IR score > 2 or elevated triglycerides revealed additional statistically significant changes in addition to those previously observed in all subjects including triglycerides (−27%), oxLDL (−19%), LDL/HDL (−25%), triglycerides/HDL (−27%), oxLDL/HDL (−25%), and PAI-1 (−37%). A follow-up case report of a 70-year-old female patient, nonresponsive to statin therapy and placed on F105 daily, demonstrated improved cardiometabolic variables over 12 weeks similar to the subgroup. In summary, F105 was clinically well-tolerated and effective for ameliorating dyslipidemia in subjects with moderate cardiometabolic risk factors, particularly in the individuals with HbA1c > 5.4%.Key words: cardiometabolic disease, bergamot, antioxidant, myeloperoxidase, oxidized LDL, dyslipidemia, HbA1c. Résumé :Les auteurs ont examiné la sécurité et l'efficacité cliniques du F105 chez 11 sujets présentant une dyslipidémie modérée. Le F105 est une combinaison d'extrait de bergamote (Citrus bergamia, EB) et 9 extraits végétaux sélectionnés pour leur capacité à améliorer l'activité antioxydante et anti-inflammatoire de l'EB. In vitro, le F105 montrait une inhibition synergique de la capacité d'absorption des radicaux d'oxygène, de formation de peroxynitrite et de l'activité myéloperoxydase. Après 12 semaines d'administration quotidienne de F105, aucun effet secondaire indésirable relié au traitement ou changements de poids corporels n'étaient observés. Des changements statistiquement significatifs ont été notés quant au cholestérol total (−7,3 %), LDL-cholestérol (−10 %), non-HDL-cholestérol (−7,1 %), cholestérol/HDL (−26 %) et apolipoprotéine B (−2,8 %). Une analyse post hoc de 8 sujets présentant une HbA1c > 5.4 et un indice HOMA-IR >2 ou des triglycérides élevés a révélé des changements additionnels statistiquement significatifs en plus de ceux précédemment observés chez tous les sujets incluant les triglycérides (−27 %), oxLDL (−19 %), LDL/HDL (−25 %) triglycérides/HDL (−27 %), oxLDL/HDL (−25 %), et PAI-1 (−37 %). Une étude de cas de suivi d'une patiente de 70 ans, ne répondant pas à la thérapie par les statines et traitée au F105 quotidiennement, a démontré amélioration des variables cardiométaboliques pendant les 12 semaines similaire au sous-groupe. En résumé, le F105 est bie...

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“…A longer dietary exposure may be necessary to produce significant effects. 39,40 This was the first study to examine the Korean and DGA dietary patterns in a controlled manner compared to a typical American diet. Because of the major differences in the three dietary patterns, one limitation includes the inability to completely blind the diets.…”

Section: Discussionmentioning

confidence: 99%