Inflammatory aortic aneurysm is associated with increased incidence of autoimmune disease

Haug, Erik Skaaheim; Skomsvoll, Johan Fredrik; Jacobsen, Gordon; Halvorsen, Tore; Sæther, Oddbjørn; Myhre, Hans O.

doi:10.1016/s0741-5214(03)00340-9

Cited by 77 publications

(58 citation statements)

References 33 publications

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“…A recent case-control study that compared inflammatory and noninflammatory abdominal aortic aneurysms showed that IAAAs are more (6). Likewise, in a recent study, we found that in 7 (44%) of 16 cases CP was associated with other autoimmune conditions, namely ANCA-positive renal disease and autoimmune tyroiditis (7).…”

Section: Discussionsupporting

confidence: 62%

Positron emission tomography (PET): Evaluation of chronic periaortitis

Salvarani¹,

Pipitone²,

Versari³

et al. 2005

Arthritis & Rheumatism

130

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Objective. To evaluate the presence and extent of large-vessel inflammation in patients with chronic periaortitis (CP) using 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET). Methods. A consecutive case series consisting of 7 patients with CP seen over a 3-year period and a control group of 14 patients with malignancy were evaluated with FDG-PET. For every case we selected 2 age-and sex-matched controls who underwent PET imaging for malignancy. The diagnosis of CP was made by means of computed tomography. PET imaging was performed at diagnosis before therapy was started. Measurement of vascular uptake was graded using a 4-point semiquantitative scale. Results. All patients had evidence of grade 2؉ or 3؉ vascular uptake in the abdominal aorta and/or iliac artery. No controls showed vascular uptake greater than 1؉. Vascular uptake in the thoracic aorta and/or in its branches was seen in 3 (43%) of 7 patients. Vascular uptake in abdominal aorta and/or iliac artery was observed in patients with CP but not in controls (100% versus 0%). There was also a significantly more frequent FDG uptake in the large thoracic arteries in case-patients compared with controls (43% versus 0%; P ‫؍‬ 0.03). Conclusion. FDG-PET scan shows in patients with CP the presence of a large-vessel vasculitis involving abdominal aorta and common iliac arteries, which in some patients is also extended to thoracic aorta and/or its branches.

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Section: Discussionsupporting

confidence: 62%

Positron emission tomography (PET): Evaluation of chronic periaortitis

Salvarani¹,

Pipitone²,

Versari³

et al. 2005

Arthritis & Rheumatism

130

View full text Add to dashboard Cite

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“…The described association with autoimmune disorders and the often observed beneficial response to immunosupressive treatment would further fit the proposed hypothesis (9,10).…”

Section: Introductionsupporting

confidence: 65%

“…An association between chronic periaortitis and HLA-DRB1*03, an allele linked to several autoimmune conditions, was recently noted (42). This might explain the simultaneous occurrence of autoimmune disorders (e.g., lupus erythematosus, Wegener's granulomatotis, polymyalgia rheumatica) in some patients with chronic periaortitis (9,10,16) and the often observed beneficial response to immunosuppressive treatment (13). One might speculate that in predisposed patients, an exaggerated and persistent inflammatory response with subsequent development of chronic periaortitis results from the same stimuli and mechanisms that are involved in atherosclerosis development per se.…”

Section: Discussionmentioning

confidence: 97%

Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case–control study

et al. 2009

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Objective: Chronic periaortitis is thought to result from an autoallergic reaction to oxidized low-density lipoprotein (OxLDL). No data exist on lipid profile and atherosclerotic biomarkers. We investigated circulating levels of OxLDL and of anti-OxLDL (aOxLDL) antibodies in patients with chronic periaortitis. Conclusion: Data suggest a differing innate immune response to OxLDL in patients with chronic periaortitis compared to controls. Whether this response is causally related to chronic periaortitis development remains to be clarified. Methods

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“…As other investigators have also suggested, vascular inflammation may lower vessel wall resistance, causing increased susceptibility to the formation of aortic aneurysms in patients with inflammatory rheumatic disease (17)(18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 79%

Inflammatory rheumatic disease and smoking are predictors of aortic inflammation: A controlled study of biopsy specimens obtained at coronary artery surgery

Hollan¹,

Scott²,

Saatvedt³

et al. 2007

Arthritis & Rheumatism

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Objective. Several inflammatory rheumatic diseases are associated with accelerated atherosclerosis. Atherosclerosis may result from systemic and/or local vascular inflammation. The aim of this study was to evaluate the occurrence of chronic inflammatory infiltrates in the aortas of patients with and those without inflammatory rheumatic disease who had undergone coronary artery bypass graft (CABG) surgery, and to assess the relationship between the infiltrates and other factors thought to play a role in atherosclerosis, such as smoking.Methods. Aortic specimens routinely removed during CABG surgery in 66 consecutive patients with inflammatory rheumatic disease and 51 control patients without inflammatory rheumatic disease were examined by light microscopy for the occurrence, location, and severity of chronic inflammatory infiltrates and atherosclerotic lesions.Results. Mononuclear cell infiltrates in the inner adventitia (apart from those localized along the epicardium) were more frequent in the group of patients with inflammatory rheumatic disease (47% versus 20%; P ‫؍‬ 0.002, odds ratio [OR] OR 3.6, 95% confidence interval [95% CI] 1.6-8.5), and the extent of these infiltrates was greater. Multivariate analyses revealed that the occurrence of mononuclear cell infiltrates was associated with inflammatory rheumatic disease (OR 2.99, P ‫؍‬ 0.020) and current smoking (OR 3.93, P ‫؍‬ 0.012), and they were observed in 6 of 7 patients with a history of aortic aneurysm. Inflammatory infiltrates in the media were seen only in patients with inflammatory rheumatic disease. The frequency of atherosclerotic lesions, inflammation within the plaques, and epicardial inflammatory infiltrates in the 2 groups was equal.Conclusion. Among aortic samples collected during CABG surgery, those obtained from patients with inflammatory rheumatic disease had more pronounced chronic inflammatory infiltration in the media and inner adventitia than those obtained from control patients. Current smoking was an independent predictor of chronic inner adventitial infiltrates. The infiltrates may represent an inflammatory process that promotes atherosclerosis and formation of aneurysms.Several inflammatory rheumatic diseases, such as rheumatoid arthritis (RA) and systemic lupus erythem-

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Inflammatory aortic aneurysm is associated with increased incidence of autoimmune disease

Cited by 77 publications

References 33 publications

Positron emission tomography (PET): Evaluation of chronic periaortitis

Positron emission tomography (PET): Evaluation of chronic periaortitis

Autoantibodies against oxidized low-density lipoprotein and lipid profile in patients with chronic periaortitis: case–control study

Inflammatory rheumatic disease and smoking are predictors of aortic inflammation: A controlled study of biopsy specimens obtained at coronary artery surgery

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