Inflammatory and repair serum biomarker pattern. Association to clinical outcomes in COPD

Pinto-Plata, Víctor; Casanova, Ciro; Müllerová, Hana; de-Torres, Juan P.; Corado, Henneth; Varo, Nerea; Cordoba, Elizabeth; Zeineldine, Salah; Paz, Hildegarde; Baz, Rebeca; Divo, Miguel; Cortopassi, Felipe; Celli, Bartolomé R.

doi:10.1186/1465-9921-13-71

Cited by 66 publications

(61 citation statements)

References 43 publications

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“…In another study, an increased level of TNF-a and IL-8 in COPD patients, compared to healthy smokers was not shown [18]. Whereas Pinto-Plata demonstrated that TNF-a and IL-6 levels increase with COPD severity of [19]. Engström et al showed a negative correlation between concentration of CCL16 protein and the degree of hyperinflation measured with RV/TLC, whereas in patients with FEV 1 %FVC < 0.7, a negative correlation between CRP and FEV 1 , FVC, RV/TLC and DLCO was found [19].…”

Section: Discussionmentioning

confidence: 89%

Correlation between Hyperinflation Defined as an Elevated RV/TLC Ratio and Body Composition and Cytokine Profile in Patients with Chronic Obstructive Pulmonary Disease

Rubinsztajn¹,

Przybyłowski²,

Maskey-Warzęchowska³

et al. 2015

Advances in Respiratory Medicine

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Correlation between hyperinflation defined as an elevated RV/TLC ratio and body composition and cytokine profile in patients with chronic obstructive pulmonary disease Korelacje pomiędzy rozdęciem miąższu płucnego mierzonego wskaźnikiem RV%TLC i składem ciała oraz profilem cytokinowym u chorych na przewlekłą obturacyjną chorobę płucThe study was performed as the part of National Center for Research and Development project "Chronic obstructive pulmonary disease (COPD) -systemic disease, the biggest threat of XXI century" (NO. 13 0034 06/2009). AbstractIntroduction: Body composition is an important prognostic factor in patients with COPD. The decrease in fat free mass (FFM), muscle mass (MM) and increase in visceral fat is associated with an elevated secretion of cytokines which promote systemic inflammation. The aim of the study was to evaluate body composition and the cytokine profile in patients with COPD in relation with the presence of hyperinflation. Material and methods:The study group consisted of 149 patients (61F, 88M) with stable COPD in all stages of severity aged 68 ± 8.8 yrs. All the patients underwent spirometry and bodypletysmography with bronchial reversibility testing. Hyperinflation was defined as RV%TLC > 48% and > 126% predicted. Body composition was analyzed by bioimpedance. The following serum inflammatory markers were evaluated: C-reactive protein, IL-6, IL-8, TNF-a, CC16, adiponectin and resistin. Results: Hyperinflation was found in 96 patients (group A) and it was more frequent in women than men (49/61 vs. 47/88, p < 0.001). BMI and age in this group were comparable to those in patients without hyperinflation (group B). Patients with hyperinflation have lover FFM, FFM index, MM and MM index and total body water and higher fat mass and fat mass index. We found significantly higher serum concentrations of inflammatory markers in group A: IL-6 -6.4 ± 10.9 vs. 3.6 ± 4.2 pg/ml, resistin -9.3 ± 4.2 vs. 7.6 ± 2.4 ng/ml, CRP 4.1 ± 2.3 vs. 2.9±2.1 mg/l, respectively. Conclusions: Patients with hyperinflation have a lower FFMI, TBW and MMI and a higher proportion of fat tissue. Hyperinflation is associated with elevated concentrations of inflammatory markers what may be associated with more severe disease. Body compositions abnormality and higher activity of systemic inflammation could therefore be a negative prognostic factor in COPD patients.

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Section: Discussionmentioning

confidence: 89%

Correlation between Hyperinflation Defined as an Elevated RV/TLC Ratio and Body Composition and Cytokine Profile in Patients with Chronic Obstructive Pulmonary Disease

Rubinsztajn¹,

Przybyłowski²,

Maskey-Warzęchowska³

et al. 2015

Advances in Respiratory Medicine

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“…PARC was shown to be elevated in COPD patients when compared to healthy smoking controls [66,73] , and an association between the levels of PARC and body mass index, FEV 1 , BODE index, and exacerbation rate was observed [24] . However, in later work only a statistically relevant association with the BODE index was reconfirmed [72] . Furthermore, elevated blood PARC levels have been associated with a higher risk of mortality and exacerbation episodes in COPD patients [86][87][88] .…”

Section: Prioritized Copd Protein Biomarkersmentioning

confidence: 94%

“…Accumulating evidence indicates that chronic inflammatory and immune responses play key roles in the development and progression of COPD [60,61] . In this respect, most of the potential biomarkers included in our list are proteins involved in inflammation or the immune response such as CRP, IL-6, beta defensin 2, among many others [25][26][27]29,36,37,54,[62][63][64][65][66][67][68][69][70][71][72][73][74] . One of the main causes leading to COPD is chronic smoking which exposes the respiratory tract to reactive oxygen species, resulting in oxidative stress and injury (which in the last instance leads also to inflammation) [59,75] .…”

Section: Copd Protein Biomarkersmentioning

confidence: 99%

“…Furthermore, one of the main components of COPD is emphysema which is caused by an imbalance between proteases and anti-proteases resulting in lung parenchymal destruction. Representative molecules of this process are MMP's [66,72] involved in the breakdown of the extracellular matrix and in tissue remodeling, as well as, VEGF involved in angiogenesis and tissue remodeling [72] . Furthermore, our protein list comprises lung-specific proteins such as SPD and CC-16 [76][77][78][79] .…”

Section: Copd Protein Biomarkersmentioning

confidence: 99%

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Prioritization of COPD protein biomarkers, based on a systematic study of the literature

Camacho¹,

Klont²,

Horvatovich³

et al. 2016

Adv Precis Med

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Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease mostly due to smoking and until now diagnosed by spirometry (post bronchodilator FEV 1 /FVC <70%). However, in spite of the usefulness of FEV 1 as diagnostic and prognostic tool, it has proven to be a weak indicator of future exacerbations, unable to predict lung function decline within COPD patients, as well as unable to identify the smokers "susceptible" to developing COPD at an early stage. Thus, there is an urgent need for biomarkers that address these questions and support clinical decision making in the diagnosis and treatment of (early) COPD. In this respect, considerable efforts have been devoted to identifying protein biomarkers that enable a better understanding of this complex disease and leading to better diagnostic and prognostic tools. However, in spite of the wide range of candidates that have been suggested as potentially useful COPD biomarkers, most remained at the level of the initial discovery, and only fibrinogen has been approved by the Food and Drug Administration (FDA) as predictor for all-cause mortality and COPD exacerbations. There is thus a need for future investigations of these biomarkers in large-scale and well characterized studies in order to prove their usefulness as surrogate endpoints. Based on this, the aim of the present review is to advance COPD biomarker development by providing a comprehensive overview of protein biomarker candidates which have been evaluated in clinical studies and prioritize them according to their potential of becoming valid, clinically useful COPD biomarkers.

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“…Serum myeloperoxidase is related to rapid decline in lung function in COPD patients 63 . Research on exhaled volatile organic compounds in pulmonary disease, and the balance between inflammatory and repair serum biomarker patterns is promising [64][65] .…”

Section: Copd and Biomarkersmentioning

confidence: 99%

Intensive care in chronic obstructive pulmonary disease : treatment with non-invasive ventilation and long-term outcome

Berkius¹

2013

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Inflammatory and repair serum biomarker pattern. Association to clinical outcomes in COPD

Cited by 66 publications

References 43 publications

Correlation between Hyperinflation Defined as an Elevated RV/TLC Ratio and Body Composition and Cytokine Profile in Patients with Chronic Obstructive Pulmonary Disease

Correlation between Hyperinflation Defined as an Elevated RV/TLC Ratio and Body Composition and Cytokine Profile in Patients with Chronic Obstructive Pulmonary Disease

Prioritization of COPD protein biomarkers, based on a systematic study of the literature

Intensive care in chronic obstructive pulmonary disease : treatment with non-invasive ventilation and long-term outcome

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