Inflammatory and Oxidative Responses in Pregnancies With Obesity and Periodontal Disease

Zambon, Marta; Mandò, Chiara; Lissoni, Alessandra; Anelli, Gaia Maria; Novielli, Chiara; Cardellicchio, Manuela; Leone, Roberto; Monari, Marta; Massari, Maddalena; Cetin, Irene; Abati, S.

doi:10.1177/1933719117749758

Cited by 45 publications

(55 citation statements)

References 58 publications

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“…Some previous studies have reported a positive association between excessive weight and periodontitis during pregnancy. Nonetheless, these studies used different methodologies for the classification of periodontitis and nutritional status.…”

Section: Discussionmentioning

confidence: 99%

“…Considering that both obesity and pregnancy may negatively impact the periodontal condition, the periodontal response should be assessed in pregnant women with obesity during pregnancy. Reports have indicated the association between overweight/obese status and periodontitis during pregnancy [16][17][18][19][20][21] . However, due to the heterogeneity of definition of periodontitis and obesity in those studies, comparison between studies is not possible.…”

Section: Introductionmentioning

confidence: 99%

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Systemic and oral conditions of pregnant women with excessive weight assisted in a private health system

Fusco

Foratori‐Junior

Missio

et al. 2019

International Dental Journal

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Objective This observational cross‐sectional study aimed to evaluate systemic and oral conditions in pregnant women with excessive pre‐pregnancy weight (PEW) and normal pre‐pregnancy weight (PNW) who underwent follow‐up in the private healthcare system during the third trimester of pregnancy. Methods Fifty pregnant women were evaluated from August 2017 to February 2018 and divided into two groups: women with PEW (n = 25); and those with PNW (n = 25). Their weight and body mass index (BMI), periodontal disease status, stimulated salivary flow, and systemic condition were evaluated. Statistical analyses were conducted using t‐test, Mann–Whitney test, chi‐square test and binary logistic regression (P < 0.05). Results The groups did not differ in age, educational level or monthly household income (P > 0.05). The PEW group had a higher frequency of arterial hypertension (P = 0.019) and excessive weight gain during gestation (P = 0.010), sought dental services less frequently, and had increased severity of periodontitis (P < 0.0001). Both groups presented low salivary flow, with no intergroup difference. In the final binary logistic regression models, high maternal pre‐pregnancy BMI was a significant predictor of arterial hypertension and periodontitis during the third trimester of gestation; maternal excessive weight gain was also a significant predictor of periodontitis during pregnancy. Conclusion Women with PEW who underwent follow‐up in a private healthcare system had a higher prevalence of arterial hypertension and worse periodontal status during the third trimester of pregnancy as compared to women with normal weight.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic and oral conditions of pregnant women with excessive weight assisted in a private health system

Fusco

Foratori‐Junior

Missio

et al. 2019

International Dental Journal

View full text Add to dashboard Cite

show abstract

“…Zambon et al (35) documented that obesity amplify the inflammatory and oxidative status during pregnancy resulting in increased local and systemic biomarkers particularly when GDM is diagnosed. Also, Lindsay et al (36) reported a high rate of IR among pregnant women of moderately older age and high rate of obesity especially if diagnosed late in gestation.…”

Section: Discussion:-mentioning

confidence: 99%

Reciprocal Relationship Between Insulin Resistance and Disturbed Adma/No Axis in Gestational Diabetes Mellitus.

MD¹,

MD²,

MD³

2018

IJAR

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Objectives: To estimate serum nitric oxide (NO) and asymmetric dimethylarginine (ADMA) levels in pregnant women and correlate it with severity of gestational diabetes mellitus (GDM) judged by Oral Glucose Tolerance Test (OGTT). Patients & Methods: 225 pregnant women gave fasting blood samples to estimate baseline blood glucose (BG), and serum insulin, NO and ADMA, and to undergo OGTT. Insulin resistance (IR) was indicated by HOMA-IR score >2. At 24 th week, blood sample were re-evaluated using OGTT and women were categorized in Study (GDM) and Control (free of GDM) group. Results: At 24 th week, HOMA-IR scores were significantly higher than baseline scores and in study versus control women. Baseline serum ADMA levels were significantly higher, while serum NO levels were significantly lower in study versus control women and correlated with body mass index (BMI), GDM, BG and HOMA-IR score of all women. Serum ADMA and NO showed significant correlation with extent of serum insulin change, but low serum NO is significant predictor for development and severity of IR. Conclusion: IR induces endothelial dysfunction manifested as low serum NO and high serum ADMA. Baseline serum NO could predict the extent of serum insulin change.

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“…Type 2 diabetes mellitus is considered an aggravating factor of periodontal disease and its incidence has been increasing due to several reasons, such as sedentary lifestyle, obesity, increased life expectancy, and higher survival of diabetic patients (ZAMBON et al, 2018, WOOTON, 2018. Thus, further studies are required to assess the correlation between both diseases.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and severity of periodontal disease in type 2 diabetes mellitus patients: a cross-sectional study

Trentin¹,

Carli²,

Ferreira³

et al. 2018

Biosci. J.

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This is a cross-sectional clinical study performed with type 2 diabetes mellitus patients and nondiabetic patients, in the city of Passo Fundo, RS, Brazil, which aimed to verify whether periodontal disease is more prevalent in type 2 diabetes mellitus (DM2) patients. The study sample included 275 patients, wherein 117 were type 2 diabetes patients and 158 were non-diabetic patients, who were assessed between the years of 2007 and 2010. The inclusion criteria of the study were patients older than 35 years with DM2 diagnosed for more than one year through glycemia and glycosylated hemoglobin tests. The same criteria was used for the control group, except for the presence of diabetes. The participants were evaluated by students calibrated for the Periodontal Screening and Recording (PSR) index and through a questionnaire assessing age, gender, oral hygiene conditions, and medications of the patients. Generalized gingivitis was more prevalent in diabetic patients (p<0.001). The level of oral hygiene of the diabetic patients was considered fair and poor (p<0.001) when compared to the non-diabetic patients. More sextants with periodontal health were observed in non-diabetic patients (p<00.1) when compared to type 2 diabetes mellitus patients; tooth loss was also greater in DM2 patients. The study allowed concluding that DM2 patients presented higher prevalence of periodontal disease than the control group. The factors that might have influenced these results were systemic condition (DM2), level of oral hygiene, and age, which justifies the high rate of periodontal disease and tooth loss in these individuals.

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Inflammatory and Oxidative Responses in Pregnancies With Obesity and Periodontal Disease

Abstract: Obesity and periodontal disease could synergistically amplify the inflammatory and oxidative status, resulting in increased local and systemic biomarkers particularly when GDM is diagnosed.

Cited by 45 publications

References 58 publications

Systemic and oral conditions of pregnant women with excessive weight assisted in a private health system

Systemic and oral conditions of pregnant women with excessive weight assisted in a private health system

Reciprocal Relationship Between Insulin Resistance and Disturbed Adma/No Axis in Gestational Diabetes Mellitus.

Prevalence and severity of periodontal disease in type 2 diabetes mellitus patients: a cross-sectional study

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