Inflammatory and Hemostatic Changes in Baboon Heatstroke Model

Bouchama, Abderrezak; Roberts, George T.; Mohanna, Falah Al; El-Sayed, Raafat; Nakeeb, Shaheen; Ollivier, Véronique; Chollet‐Martin, Sylvie; Prost, Dominique de

doi:10.1097/00003246-200412001-00466

Cited by 1 publication

(4 citation statements)

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“…7.9 The mechanisms underpinning SIRS in dogs with heatstroke are multifactorial, including the production and/or suppression of cytokines. [10][11][12][13] Cytokines may be either pro-or anti-inflammatory.…”

Section: Discussionmentioning

confidence: 99%

“…TA B L E 3 Concentrations of interleukin-6 (IL-6), IL-8, IL-10, and monocyte chemoattractant protein-1 (MCP-1) measured before, during, and after the first extracorporeal therapy session, along with extraction ratio (ER%), in a 3-year-old dog treated for sequelae of exertional heatstroke Both categories of cytokines are considered to play a role in the pathogenesis of heatstroke. Models of environmental and exertional heatrelated illness have demonstrated associations between the degree of an individual's inflammatory response and the severity of their clinical signs and chance of survival, 13 as well as identifiable patterns in cytokine concentrations based on mechanism of hyperthermia. 3 Therapeutic attenuation of the cytokine response using ECT has previously been investigated in sepsis.…”

Section: Discussionmentioning

confidence: 99%

“…Both categories of cytokines are considered to play a role in the pathogenesis of heatstroke. Models of environmental and exertional heat‐related illness have demonstrated associations between the degree of an individual's inflammatory response and the severity of their clinical signs and chance of survival, 13 as well as identifiable patterns in cytokine concentrations based on mechanism of hyperthermia 3 …”

Section: Discussionmentioning

confidence: 99%

“…In response to this, repeated doses of calcium gluconate 10% x (0.5 mL/kg, IV), regular insulin y (0.1 U/kg, IV) and dextrose (0.125 g/kg, IV), and terbutaline z (0.01 mg/kg, IV) were administered over the course of the subsequent 8 h, guided by the dog's ECG and serum potassium concentration. Because the dog displayed a lymphocytosis and eosinophilia despite severe illness and persistent refractory hypoglycemia, an ACTH-stimulation test aa was also performed but was not consistent with adrenal insufficiency (pre-ACTH cortisol 383.5 nmol/L[13…”

mentioning

confidence: 99%

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Use of extracorporeal therapy in a dog with heatstroke

Tracy

Lynch

Messenger

et al. 2021

J Vet Emergen Crit Care

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Objective: To describe the use of extracorporeal therapy (ECT) in the management of a dog with complications stemming from heatstroke.Case Review: A 3-year-old intact male Rhodesian Ridgeback was presented for heatrelated illness following strenuous exercise. Despite intensive supportive care, the dog developed progressive and refractory hyperkalemia, hypoglycemia, neurologic dysfunction, acute kidney injury (AKI), and pulmonary dysfunction. Four ECT sessions were performed in this dog, consisting of 4 intermittent hemodialysis (HD) sessions, the first 2 of which concurrently utilized hemoperfusion with a cytokine adsorption filter. Interleukin-6 (IL-6), IL-8, IL-10, and monocyte chemoattractant protein-1 were detected in samples collected during the first ECT session. Despite an initial decrease in their concentration, the concentrations of these cytokines ultimately rose over the course of the ECT session. Rapid and sustained glycemic and electrolyte control were achieved after the first ECT session, although AKI and muscle injury persisted. The dog survived to discharge and was nonazotemic 3 months following initial management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%