Use of extracorporeal therapy in a dog with heatstroke

Tracy, Alyx; Lynch, Alex; Messenger, Kristen M.; Vaden, Shelly L.; Vigani, Alessio

doi:10.1111/vec.13169

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…In septic patients, there is improvement in immune cell function characterized by reduced neutrophil extracellular trap formation and improved leukocyte response to antigen stimulation ( 7 ). Hemoperfusion has also been used in small animal veterinary patients for treatment of exogenous and endogenous intoxications, immune-mediated conditions ( 8 ), and heatstroke with cytokine dysregulation ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Feasibility of hemoperfusion using extracorporeal therapy in the horse

Hobbs,

Le Sueur,

Burke

et al. 2024

Front. Vet. Sci.

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ObjectiveDevelop, implement, and monitor for adverse effects of, a novel hemoperfusion therapy in adult horses.MethodsA prospective, observational feasibility study using three healthy adult horses from the North Carolina State University teaching herd. Health status was determined by physical exam, complete blood count, coagulation panel, and serum biochemistry. Each horse was instrumented with a 14 Fr × 25 cm double-lumen temporary hemodialysis catheter and underwent a 240 min polymer-based hemoperfusion session. Horses were administered unfractionated heparin to maintain anti-coagulation during the session. Given the novelty of this therapy in horses, each horse was treated as a learning opportunity that informed an iterative process of protocol development and modification.Measurements and main resultsOur long-term goal is to investigate potential clinical applications of hemoperfusion in horses, including cytokine reduction in horses with severe SIRS/sepsis. Horses were monitored for changes in clinical exam, biochemistry and hematology parameters. Additionally, cytokines were quantified to determine whether extracorporeal hemadsorption therapy alone caused an inflammatory response. Our results show that hemoperfusion therapy was associated with decreased platelet counts and serum albumin concentration. There was no significant change in plasma cytokine concentrations with hemoperfusion therapy. In one horse, the cytokine concentrations decreased, as previously reported with hemoperfusion therapy in humans.HypothesisWe hypothesized that hemoperfusion therapy could be performed in healthy adult horses without significant adverse effects.ConclusionPolymer-based hemoperfusion is a feasible extracorporeal therapy (ECT) modality for adult horses. Additional studies are needed to further establish clinical protocols, as well as establish efficacy of polymer-based hemoperfusion for treatment of various conditions in horses, including intoxications, immune-mediated conditions, and sepsis.

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Section: Introductionmentioning

confidence: 99%

Feasibility of hemoperfusion using extracorporeal therapy in the horse

Hobbs,

Le Sueur,

Burke

et al. 2024

Front. Vet. Sci.

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Use of extracorporeal hemoperfusion therapy in an adult horse with Clostridioides difficile colitis and severe systemic inflammatory response syndrome

Hobbs,

Le Sueur,

Hallowell

et al. 2024

Veterinary Internal Medicne

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An 8‐year‐old American Quarter Horse gelding was treated with extracorporeal hemoperfusion (HP) therapy for treatment of Clostridioides difficile (C. difficile) colitis‐induced systemic inflammatory response syndrome (SIRS). The gelding developed C. difficile associated peracute colitis and severe SIRS as evidenced by a positive fecal C. difficile PCR and tachypnea, tachycardia, fever, neutropenia, altered mucous membrane color, and hyperlactatemia. Concurrent acute kidney injury in the horse limited the use of routine anti‐inflammatory and anti‐lipopolysaccharide treatments, including flunixin meglumine and polymyxin B, because of potential for nephrosis. Extracorporeal HP therapy was performed twice within 48 hours of the onset of severe SIRS during which the horse's physical examination variables stabilized. The horse was euthanized after 4 days because of laminitis. These findings support further investigation of extracorporeal HP therapy as an adjunctive treatment for severe SIRS/sepsis in horses.

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Use of extracorporeal therapy in a dog with heatstroke

Cited by 2 publications

References 23 publications

Feasibility of hemoperfusion using extracorporeal therapy in the horse

Feasibility of hemoperfusion using extracorporeal therapy in the horse

Use of extracorporeal hemoperfusion therapy in an adult horse with Clostridioides difficile colitis and severe systemic inflammatory response syndrome

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