Inflammatory and degranulation effect of yellow sand on RBL-2H3 cells in relation to chemical and biological constituents

Yamada, Parida; Hatta, Toshihisa; Du, Mingyuan; Wakimizu, Kenji; Han, Jianzhong; Maki, Taichi; Isoda, Hiroko

doi:10.1016/j.ecoenv.2012.05.021

Cited by 14 publications

(19 citation statements)

References 49 publications

(60 reference statements)

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“…Compared to these values, the resistivity values of tailings are much lower, which can be explained in relation to the difference in their chemical compositions and particle sizes [17]. The iron ore tailings used in the current study had higher Fe 2 O 3 content of 25.13% as seen in Table 2 as compared with the iron content reported for sand as (0.59-6.58%) [18] and (1.15-3.98%) [19]. There is a possibility that the higher Fe 2 O 3 content in the iron ore mine tailings could be a contributory factor for the lower resistivity than that for the sand.…”

Section: Correction To Experimental Valuescontrasting

confidence: 59%

Electrical resistivity of iron ore mine tailings produced in Western Australia

Kuranchie

Shukla

Habibi

2014

International Journal of Mining, Reclamation and Environment

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This paper presents the details of an experimental study on the electrical resistivity of iron ore mine tailings produced in Western Australia. In the study, an experimental set-up is developed based on the Wenner Array, and has been used for determining the electrical resistivity of the tailings at different relative densities in dry and fully saturated conditions. The apparent electrical resistivity of the iron ore mine tailings ranged from 11 kΩm for a very dense state to 19 kΩm for a very loose state in dry condition; while for the fully saturated condition, the resistivity ranged from 20 to 31 Ωm for very dense state to very loose state, respectively. The results are discussed for their practical applications such as identifying weak zones in tailing embankments, extent of corrosion in buried steel pipelines, and extent of degree of compaction in structural fills

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Section: Correction To Experimental Valuescontrasting

confidence: 59%

Electrical resistivity of iron ore mine tailings produced in Western Australia

Kuranchie

Shukla

Habibi

2014

International Journal of Mining, Reclamation and Environment

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“…Previous experimental reports have indicated that ASD exhibit a cytotoxic effect in vitro (Choi et al ., ; Kim et al ., ; Yamada et al ., ) and in vivo (Lei et al ., ; Naota et al ., ; Ichinose et al ., ). On the basis of these reports, ASD themselves which are free from chemical and biological pollutants and components adhered to ASD have possibility to cause damage in several cell population.…”

Section: Discussionmentioning

confidence: 99%

“…ASD themselves are mainly composed of silicon, aluminum, calcium and iron. Occurring in the Gobi Desert and the Ocher Plateau, ASD mix various chemical and biological materials such as sulfate (SO 4 2-), nitrate (NO 3 -), polycyclic aromatic hydrocarbons (PAH), pollen, bacteria and fungi (Ho et al, 2005;Lee et al, 2009;Maki et al, 2008Maki et al, , 2010Mori et al, 2002Mori et al, , 2003Tamamura et al, 2007;Wu et al, 2004;Yamada et al, 2012;Yeo & Kim 2002). The characteristic of ASD can change during its long-range transport, and it is concerned that not only ASD themselves but also materials adhered to ASD cause adverse health effects Naota et al, 2010Naota et al, , 2012Yanagisawa et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of Asian sand dust particles on the respiratory and immune system

Honda

Matsuda

Murayama

et al. 2013

J of Applied Toxicology

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Epidemiologic studies have reported that Asian sand dust (ASD) particles can affect respiratory health; however, the mechanisms remain unclear. We investigated the effects of ASD on airway epithelial cells and immune cells, and their contributing factors to the effects. Human airway epithelial cells were exposed to ASD collected on 1-3 May (ASD1) and on 12-14 May (ASD2) 2011 in Japan and heat-treated ASD1 for excluding heat-sensitive substances (H-ASD) at a concentration of 0, 3, 30 or 90 µg ml(-1) for 4 or 24 h. Furthermore, bone marrow-derived dendritic cells (BMDC) from atopic prone mice were differentiated by culture with granulocyte-macrophage colony-stimulating factor (GM-CSF) then these BMDC were exposed to the ASD for 24 h. Also splenocytes as mixture of immune cells were exposed to the ASD for 72 h. All ASD dose dependently reduced viability of airway epithelial cells. Non-heated ASD showed a dose-dependent increase in the protein release of interleukin (IL)-6 and IL-8. The raises induced by ASD1 were higher than those by ASD2. ASD1 and ASD2 also elevated ICAM-1 at the levels of mRNA, cell surface protein and soluble protein in culture medium. In contrast, H-ASD did not change most of these biomarkers. Non-heated ASD showed enhancement in the protein expression of DEC205 on BMDC and in the proliferation of splenocytes, whereas H-ASD did not. These results suggest that ASD affect airway epithelial cells and immune cells such as BMDC and splenocytes. Moreover, the difference in ASD events and components adhered to ASD can contribute to the health effects.

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“…These results suggest that ASD induces an adjuvant effect on type I allergy. It has also been reported that ASD is involved in mast cell degranulation [37]. Taken together, these results lead us to speculate that ASD may enhance mast cell degranulation in the presence of low levels of JCP that would not induce mast cell degranulation in a normal setting.…”

Section: Discussionmentioning

confidence: 70%

“…4). Given that ASD exhibits strong cytotoxic effects, and that even in non-atopic patients, an ASD event will exacerbate itchy eyes [37], it might be assumed that ASD cytotoxicity was involved in the increase in itchy eye symptoms in the post-JCP season. A level of minimum persistent inflammation (MPI) may be present in the nose after the JCP season, and ASD could be a trigger that increases the extent of MPI in SAR-JCP patients.…”

Section: Discussionmentioning

confidence: 99%