Inflammation-specific targeted carriers for local drug delivery to inflammatory bowel disease

Kotla, Niranjan G.; Singh, Rajbir; Baby, Becca V.; Rasala, Swetha; Rasool, Jawad; Hynes, Seán O.; Martin, Darrell; Egan, Laurence J.; Vemula, Praveen Kumar; Jala, Venkatakrishna R.; Rochev, Yury; Pandit, Abhay

doi:10.1016/j.biomaterials.2022.121364

Cited by 49 publications

(22 citation statements)

References 53 publications

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“…Clinical assessment of induced colitis was launched by measuring the disease activity index (DAI) blindly from day 1 to day 14 in the experiment. , Colon lengths were measured, and spleen weights were calculated as gross macroscopic indicators of colitis severity.…”

Section: Methodsmentioning

confidence: 99%

“…Inflammatory bowel disease (IBD) is a chronic autoimmune disease that is characterized by relapsing intestinal inflammation. − In the past decade, IBD has emerged as a public health challenge worldwide, affecting more than 6.8 million people, especially in western countries . There are two main forms: ulcerative colitis (UC) and Crohn’s disease (CD). , Although they share many clinical features, they are considered as distinct conditions, as their inflammatory prone areas are completely different.…”

Section: Introductionmentioning

confidence: 99%

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Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Zhang

et al. 2023

Biomacromolecules

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The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn’s disease is extremely cloudy. Maintaining the level of remission lesions in colitis is the default treatment attitude at present. Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment. In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment. Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release. Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine. In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres. In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Zhang

et al. 2023

Biomacromolecules

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“…Currently, numerous in vivo animal models and in vitro methods are used to model intestinal barrier damage and study the effects of strictly anaerobic bacteria. 8 Despite interspecies differences, genetically engineered and chemically induced animal models have been applied to study IBD pathogenesis, prevention and treatment. 9 These models have aided in understanding the mechanisms through which the microbiota contributes to IBD.…”

Section: Introductionmentioning

confidence: 99%

Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease

Liu

Zheng

et al. 2023

Biomater. Sci.

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“…23 The oral administration of anti-inflammatory medications to the colon, such as antibiotics and chemotherapy agents, is necessary to treat inflammatory diseases. 24,25 As a result, delivery systems based on exploiting degradation by colonic bacterial enzymes have been developed for colonspecific delivery. 26,27 Different polysaccharidases that the intestinal microflora produces degrade polysaccharides for the most part.…”

Section: Introductionmentioning

confidence: 99%

Rapid Indomethacin Release from Porous Pectin Particles as a Colon-Targeted Drug Delivery System

Nguyen

Bahri

Rahmatika

et al. 2023

ACS Appl. Bio Mater.

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The conventional pectin delivery systems in the colon are often impaired by a slow release rate. Nanostructured particles, especially porous ones, have gained popularity as drug delivery systems owing to their high mass transfer efficiency. In this research, porous pectin particles were synthesized as drug carriers (using indomethacin as a model drug) via template-assisted spray drying. Specific surface areas of the porous pectin particles have been improved by up to 203 m2 g–1 compared with nonporous particles (1 m2 g–1). The porous structure shortened the diffusion path and improved the release rate of drug molecules. Additionally, the predominant drug release mechanism from porous pectin particles is Fickian diffusion, which is different from the combination of erosion and diffusion mechanism observed for nonporous particles. As a result, these porous drug-loaded pectin particles demonstrated rapid drug release rates of up to three times faster than nonporous particles. Control of the release rate could be achieved by changing the porous structure of the particles. This strategy is an efficient means to synthesize porous particles allowing rapid drug release into the colonic target.

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Inflammation-specific targeted carriers for local drug delivery to inflammatory bowel disease

Cited by 49 publications

References 53 publications

Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease

Rapid Indomethacin Release from Porous Pectin Particles as a Colon-Targeted Drug Delivery System

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