Rapid Indomethacin Release from Porous Pectin Particles as a Colon-Targeted Drug Delivery System

Abstract

The conventional pectin delivery systems in the colon are often impaired by a slow release rate. Nanostructured particles, especially porous ones, have gained popularity as drug delivery systems owing to their high mass transfer efficiency. In this research, porous pectin particles were synthesized as drug carriers (using indomethacin as a model drug) via template-assisted spray drying. Specific surface areas of the porous pectin particles have been improved by up to 203 m2 g–1 compared with nonporous particles (1 m2 g–1). The porous structure shortened the diffusion path and improved the release rate of drug molecules. Additionally, the predominant drug release mechanism from porous pectin particles is Fickian diffusion, which is different from the combination of erosion and diffusion mechanism observed for nonporous particles. As a result, these porous drug-loaded pectin particles demonstrated rapid drug release rates of up to three times faster than nonporous particles. Control of the release rate could be achieved by changing the porous structure of the particles. This strategy is an efficient means to synthesize porous particles allowing rapid drug release into the colonic target.

A Smart Pesticide-Controlled Release Platform with Dual Stimuli-Responsive Functions for Enhanced Treatment of Plant Black Shank

“…Table shows the diffusional exponent ( n ) and release constant ( K ) for HON release from SCRP. The results indicate that the HON-releasing kinetics from SCRP was controlled by Fickian diffusion controlled (corresponding to drug diffusion) under the pH of 6.0–7.0 ( n ≤ 0.45), while it was governed by non-Fickian diffusion kinetics (combination of shell dissolution and diffusion) under the pH of 5.0 (0.45 < n < 0.89) …”

“…The results indicate that the HON-releasing kinetics from SCRP was controlled by Fickian diffusion controlled (corresponding to drug diffusion) under the pH of 6.0−7.0 (n ≤ 0.45), while it was governed by non-Fickian diffusion kinetics (combination of shell dissolution and diffusion) under the pH of 5.0 (0.45 < n < 0.89). 36 To evaluate the adaptability of the as-designed SCRP under real conditions, the pH changes in different soils were measured under different treatment conditions after transplanting tobacco (Figure S9). Specifically, compared with the normal soil (CK−) pH of around 6.34, the pH value of P. nicotianae containing soil (CK+) dropped to 5.60 since P. nicotianae could stimulate the secretion of organic acids in tobacco root, which provides an ideal acidic pH condition for the release of HON.…”

Controllable Synthesis of Porous and Hollow Nanostructured Catalyst Particles and Their Soot Oxidation

“…The development of submicron nanostructured particles with highly controlled structures and morphologies (e.g., porous, , hollow, , and core–shell , ) is important for advancing the next generation of fine particles. − Among nanostructured particles, macroporous particles have attracted considerable attention due to their unique advantages in material performance. By introduction of macropores, the particles can efficiently utilize their internal parts and concurrently improve their performance.…”

Effects of Coating Characteristics of One-Step Aerosol Synthesized–Silica-Coated FeNi Nanostructured Particles on Powder Core Properties for Electronic Machine Development

“…Nanostructured materials have revolutionized diverse fields like energy, food, and environment due to their exceptional versatility. − Their unique properties arise from their intricate morphologies, which can vary widely including being porous, hollow, dense, core–shell, and so forth. In recent years, the rapid advancement of technology has spurred the development of electric devices demanding innovative solutions to increase efficiency and compact their designs .…”