Inflammation-modulating antibacterial hydrogel sustained release asiaticoside for infection wound healing

Chen, Xushan; Zhang, Huimin; Liang, Yonghui; Lu, Yao; Xie, Xiaoming; Jin, Tao; Ba, Li; Zhang, Xuanyue; Liu, Hanjiao

doi:10.1016/j.bioadv.2023.213302

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…The results of the immunomodulatory activity are summarized in Figure 6a,b. It is recognized that the IL-8 cytokine is secreted by macrophages as a response to skin injury and participates in the inflammation phase of wound healing [41]. IL-8 also plays a central role in regulating the functions of immune cells from the epithelialization stage, acting by assembling resident stem cells and stimulating cell proliferation and differentiation [42].…”

Section: In Vitro Investigation Of the Immunomodulatory And Antimicro...mentioning

confidence: 99%

Electrospun/3D-Printed Bicomponent Scaffold Co-Loaded with a Prodrug and a Drug with Antibacterial and Immunomodulatory Properties

et al. 2023

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This work reports the construction of a bicomponent scaffold co-loaded with both a prodrug and a drug (BiFp@Ht) as an efficient platform for wound dressing, by combining the electrospinning and 3D-printing technologies. The outer component consisted of a chitosan/polyethylene oxide-electrospun membrane loaded with the indomethacin–polyethylene glycol–indomethacin prodrug (Fp) and served as a support for printing the inner component, a gelatin methacryloyl/sodium alginate hydrogel loaded with tetracycline hydrochloride (Ht). The different architectural characteristics of the electrospun and 3D-printed layers were very well highlighted in a morphological analysis performed by Scanning Electron Microscopy (SEM). In vitro release profile studies demonstrated that both Fp and Ht layers were capable to release the loaded therapeutics in a controlled and sustained manner. According to a quantitative in vitro biological assessment, the bicomponent BiFp@Ht scaffold showed a good biocompatibility and no cytotoxic effect on HeLa cell cultures, while the highest proliferation level was noted in the case of HeLa cells seeded onto an Fp nanofibrous membrane. Furthermore, the BiFp@Ht scaffold presented an excellent antimicrobial activity against the E. coli and S. aureus bacterial strains, along with promising anti-inflammatory and proangiogenic activities, proving its potential to be used for wound dressing.

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Section: In Vitro Investigation Of the Immunomodulatory And Antimicro...mentioning

confidence: 99%

Electrospun/3D-Printed Bicomponent Scaffold Co-Loaded with a Prodrug and a Drug with Antibacterial and Immunomodulatory Properties

et al. 2023

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“…It has been proven to be widely used as a drug in fields such as antioxidant, anti-inflammatory activity, immune regulation, and burn wound healing . Moreover, it has the ability to enhance collagen protein synthesis in vitro and promote extracellular matrix accumulation in vivo. , However, Asia has almost no antibacterial properties, which cannot provide assistance for the healing process of a burn wound. Curcumin (CUR) is mainly composed of seven carbon chains and three main functional groups, including α, β-unsaturated β-diketones, and aromatic O -methoxy-phenols.…”

Section: Introductionmentioning

confidence: 99%

Dual-Drug-Loaded Core–Shell Electrospun Nanofiber Dressing for Deep Burns

Han,

Wang,

Sun

et al. 2024

ACS Appl. Bio Mater.

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The epidermis of a deep burn wound is entirely absent and the dermal tissue sustains significant damage, accompanied by a substantial amount of tissue exudate. Due to the excessively humid environment, the formation of a scab on the wound becomes challenging, leaving it highly vulnerable to external bacterial invasion. In this work, a core−shell dual-drug-loaded nanofiber dressing was prepared by electrospinning technology for the synergistic treatment of a deep burn. The shell layer consists of polycaprolactone and chitosan encapsulating asiaticoside, with the core layer comprising the clathrate of 2hydroxypropyl-β-cyclodextrin and curcumin. Upon application to the wound, the dual-drug-loaded nanofiber dressing exhibited rapid release of asiaticoside, stimulating collagen deposition and promoting tissue repair. The core−shell structure and clathrate configuration ensured sustained release of curcumin, providing antibacterial and anti-inflammatory functions for the wound. The mechanical strength, broad-spectrum antibacterial ability, cell proliferation, and adhesion ability of the nanofiber dressing showed its potential as a medical dressing. This dressing also exhibited excellent wound healing promoting effects in the SD rat burn model. This paper provides a strategy for burn wound healing.

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Preparation and characterization of a polyurethane-based sponge wound dressing with a superhydrophobic layer and an antimicrobial adherent hydrogel layer

Xu,

Zhang,

et al. 2024

Acta Biomaterialia

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Inflammation-modulating antibacterial hydrogel sustained release asiaticoside for infection wound healing

Cited by 8 publications

References 42 publications

Electrospun/3D-Printed Bicomponent Scaffold Co-Loaded with a Prodrug and a Drug with Antibacterial and Immunomodulatory Properties

Electrospun/3D-Printed Bicomponent Scaffold Co-Loaded with a Prodrug and a Drug with Antibacterial and Immunomodulatory Properties

Dual-Drug-Loaded Core–Shell Electrospun Nanofiber Dressing for Deep Burns

Preparation and characterization of a polyurethane-based sponge wound dressing with a superhydrophobic layer and an antimicrobial adherent hydrogel layer

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