Preparation and characterization of a polyurethane-based sponge wound dressing with a superhydrophobic layer and an antimicrobial adherent hydrogel layer

Xu, Hang; Zhang, Yufeng; Ma, Jinzhu; Miao, Hui; Chen, Shangliang; Gao, Shangdong; Rong, Hui; Deng, Liandong; Zhang, Jianhua; Dong, Anjie; Li, Shuangyang

doi:10.1016/j.actbio.2024.04.042

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…The rapid development of wound care today is the use of dressings or dressings based on measuring the level of existing cost capabilities, of course, adjusted to the principle of wound care, which is to maintain the physiology of moisture in the wound environment so that it can trigger the tissue repair process (Galosi et al, 2024;Xu et al, 2024). The application of wound care is more based on the findings with a multidisciplinary approach, with the principles of "moist wound healing," "advance wound healing," a moist wound environment that can send epithelial cell migration, reepithelialization, wound contraction, tissue growth, adequate debridement, clean and sterile techniques that adjust the condition of the wound (Kaminsky et al, 2022;Ou et al, 2024).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Conventional and Modern Wound Care in Post-Section Wounds at Cut Mutia Hospital, North Aceh Regency in 2023

Yusnidaryani,

Taufiq,

Fauzi

2024

JHS

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The World Health Organization (WHO) sets the average cesarean sections (CS) standard at 5-15% per 1000 births. However, cesarean section rates in private hospitals exceed 30%, compared to 11% in government hospitals. This study investigates the prevalence and complications of surgical wound infections post-cesarean section and the effectiveness of modern wound dressing techniques in reducing these infections. Data analysis reveals cesarean wound infections occur during hospitalization (27%), re-admission (1%), and post-discharge (71%). Surgical wound infections (SWI) significantly increase morbidity, treatment duration, and healthcare costs, with a direct death rate ranging from 3% to 75% globally. The study evaluated modern wound dressings adhering to "moist wound healing" principles, such as hydrocolloids, alginate, and foam, which maintain a moist environment to enhance epithelial cell proliferation, accelerate wound healing, and reduce scarring. Findings indicate that moist wound dressings significantly improve healing outcomes, promoting epithelialization and collagen synthesis, with techniques showing a 30-50% increase in epithelialization and a 2-5 times faster re-epithelialization rate. These results highlight the need for adopting advanced wound care techniques to reduce surgical wound infections and improve patient recovery post-cesarean section. The study implies that healthcare providers should integrate modern wound care practices to enhance maternal health outcomes globally.

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Section: Introductionmentioning

confidence: 99%

Comparison of Conventional and Modern Wound Care in Post-Section Wounds at Cut Mutia Hospital, North Aceh Regency in 2023

Yusnidaryani,

Taufiq,

Fauzi

2024

JHS

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Bioinspired Asymmetric‐Adhesion Janus Hydrogel Patch Regulating by Zwitterionic Polymers for Wet Tissues Adhesion and Postoperative Adhesion Prevention

Li,

Liu,

Qiao

et al. 2024

Adv Healthcare Materials

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Asymmetrically adhesive hydrogel patch with robust wet tissue adhesion simultaneously anti‐postoperative adhesion is essential for clinical applications in internal soft‐tissue repair and postoperative anti‐adhesion. Herein, inspired by the lubricative role of serosa and the underwater adhesion mechanism of mussels, an asymmetrically adhesive hydrogel Janus patch is developed with adhesion layer (AL) and anti‐adhesion layer (anti‐AL) through an in situ step‐by‐step polymerization process in the mold. The AL exhibits excellent adhesion to internal soft‐tissues. In contrast, the anti‐AL demonstrated ultralow fouling property against protein and fibroblasts, which hinders the early and advanced stages of development of the adhesion. Moreover, the Janus patch simultaneously promotes tissue regeneration via ROS clearance capability of catechol moieties in the AL. Results from in vivo experiments with rabbits and rats demonstrate that the AL strongly adheres to traumatized tissue, while the anti‐AL surface demonstrate efficacy in preventing of post‐abdominal surgery adhesions in contrast to clinical patches. Considering the advantages in terms of therapeutic efficacy and off the shelf, the Janus patch developed in this work presents a promise for preventing postoperative adhesions and promoting regeneration of internal tissue defects.

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Preparation and characterization of a polyurethane-based sponge wound dressing with a superhydrophobic layer and an antimicrobial adherent hydrogel layer

Cited by 2 publications

References 62 publications

Comparison of Conventional and Modern Wound Care in Post-Section Wounds at Cut Mutia Hospital, North Aceh Regency in 2023

Comparison of Conventional and Modern Wound Care in Post-Section Wounds at Cut Mutia Hospital, North Aceh Regency in 2023

Bioinspired Asymmetric‐Adhesion Janus Hydrogel Patch Regulating by Zwitterionic Polymers for Wet Tissues Adhesion and Postoperative Adhesion Prevention

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